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Träfflista för sökning "WFRF:(Thunberg G.) "

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Numrering	Referens	Omslagsbild	Hitta
1.	Tobin, G, et al. (författare) Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vλ2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope 2003 Ingår i: Blood. - 1528-0020. ; 101:12, s. 4952-4957 Tidskriftsartikel (refereegranskat)
2.	Tobin, G, et al. (författare) Multiple subsets with homologous immunoglobulin gene rearrangements indicate a role for antigen selection in the development of chronic lymphocytic leukemia Tidskriftsartikel (refereegranskat)
3.	Tobin, G, et al. (författare) V(a)3-21 gene utilizing chronic lymphocytic leukemias display restricted V lambda 2-14 gene usage and homologous CDR3s. 2002 Ingår i: Blood. - 0006-4971 .- 1528-0020. ; 100:11, s. 362- Konferensbidrag (övrigt vetenskapligt/konstnärligt)
4.	Berglund, M, et al. (författare) Chromosomal imbalances in diffuse large B-cell lymphoma detected by comparative genomic hybridization 2002 Ingår i: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. - 0893-3952. ; 15, s. 807- Tidskriftsartikel (refereegranskat)
5.	Gafvelin, G, et al. (författare) Cytokine and antibody responses in birch-pollen-allergic patients treated with genetically modified derivatives of the major birch pollen allergen Bet v 1 2005 Ingår i: International Archives of Allergy and Immunology. - : S. Karger AG. - 1018-2438 .- 1423-0097. ; 138:1, s. 59-66 Tidskriftsartikel (refereegranskat)abstract Background: Recently, recombinant hypoallergenic derivatives of the major birch pollen allergen, Bet v 1, were used to treat birch-pollen-allergic patients in a double-blind, placebo-controlled, multi-centre immunotherapy study. The aim of this study was to evaluate the effects of vaccination with aluminium-hydroxide-adsorbed recombinant Bet v 1 derivatives versus placebo on T-cell, cytokine and antibody responses in a subgroup of patients. Methods: Blood was drawn from patients of the Swedish centre (n=27; rBet v 1 fragments: n=10; rBet v 1 trimer: n=8, and placebo-aluminium hydroxide: n=9) before the start and after completion of the treatment. PBMC were stimulated with rBet v 1 and analysed for cytokine (IL-4, IL-5, IL-10, IL-12, IL-13 and IFN-gamma)-secreting cells by ELISpot. Bet v 1-specific antibody levels in serum (IgG(1-4), IgE and IgA) were measured by ELISA. Skin prick tests with defined Bet v 1 concentrations were performed before and 10-11 months after the beginning of the study. Results: Bet v 1-specific IgG levels, consisting of IgG 1, IgG 2 and IgG 4, were significantly increased after treatment with recombinant allergen derivatives. Treatment with rBet v 1 trimer led to a significant (p<0.05) reduction of Bet v 1-reactive IL-5- and IL-13-producing cells, reflecting a reduced Th2 response. In addition, a decreased number of Bet v 1-reactive IL-4 producing (p=0.07) and an increase of IL-12-producing (p=0.06) cells was noted in the trimer-treated patients. In contrast to placebo, active treatment resulted in significantly reduced immediate-type skin reactions to Bet v 1 even 10-11 months after treatment. Conclusion: Vaccination with recombinant hypoallergenic Bet v 1 derivatives induces a Bet v 1-specific IgG response and leads to reduced skin reactivity in allergic patients. A reduction of Bet v 1-specific Th2 responses was observed in trimer-treated patients, which may reflect the intrinsic property of this allergen derivative. Copyright (C) 2005 S. Karger AG, Basel.
6.	Gafvelin, G, et al. (författare) Pretreatment of mice with fel d 1-coupled carbohydrate-based particles protects against sensitisation with cat allergen 2007 Ingår i: ALLERGY. - 0105-4538. ; 62, s. 251-252 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
7.	Hultdin, M, et al. (författare) Association between telomere length and V(H) gene mutation status inchronic lymphocytic leukaemia: clinical and biological implications. 2003 Ingår i: Br J Cancer. ; 88, s. 593- Tidskriftsartikel (refereegranskat)
8.	Hultdin, M, et al. (författare) Telomere length and VH gene mutation status in chronic lymphocytic leukemia: Differences related to gender, age and sample site Annan publikation (övrigt vetenskapligt/konstnärligt)
9.	Neimert-Andersson, T., et al. (författare) Carbohydrate-based particles reduce allergic inflammation in a mouse model for cat allergy 2008 Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 63:5, s. 518-526 Tidskriftsartikel (refereegranskat)abstract Background: Allergen-specific immunotherapy (ASIT) is the only treatment of allergic disease that gives long-lasting relief of symptoms. However, concerns for safety and efficiency have highlighted the need for improvement of the therapy. We have previously suggested carbohydrate-based particles (CBPs) as a novel adjuvant and allergen carrier for ASIT. Our aim of this study was to evaluate the therapeutic potential of CBPs in ASIT, employing a mouse model for cat allergy. Methods: BALB/c mice were subcutaneously immunized with the recombinant (r) cat allergen Fel d 1 followed by intranasal challenge with cat dander extract (CDE). The sensitized mice were therapeutically treated with rFel d 1 covalently coupled to CBPs (CBP-rFel d 1). Airway hyper-reactivity (AHR), infiltration of leucocytes in bronchoalveolar lavage (BAL) fluid, allergen-specific serum immunoglobulin levels and in vitro splenocyte responses were evaluated. Results: Mice treated with CBP-rFel d 1 showed reduced features of allergic inflammation. They responded with (i) significantly decreased AHR and infiltration of eosinophils in BAL fluid after CDE challenge, (ii) the serum level of rFel d 1-specific IgE was reduced and the level of IgG(2)a was more pronounced after CBP-rFel d 1 treatment, and (iii) there was also a tendency of decreased allergen-specific cellular response. Conclusions: Carbohydrate-based particles are effective tools as adjuvant and allergen carriers for use in ASIT and constitutes a promising strategy to improve allergy treatment.
10.	Rosenquist, R, et al. (författare) Clonal evolution as judged by immunoglobulin heavy chain generearrangements in relapsing precursor-B acute lymphoblastic leukemia. 1999 Ingår i: Eur J Haematol. ; 63, s. 171- Tidskriftsartikel (refereegranskat)

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Författare/redaktör: Thunberg, U (24); Rosenquist, R. (18); Sundstrom, C (13); van Hage, M (11); Gafvelin, G (11); Johnson, A (10); visa fler...; Roos, G (10); Enblad, G. (9); Thunberg, Sarah, 197 ... (9); Gronlund, H (7); Sundström, C (7); Eriksson, I (6); Thunberg, S (6); Thunberg, G. (6); Merup, M (5); Karlsson, K (5); Scheynius, A (4); Swedin, L (4); Akdis, M (4); Sallstrom, J (4); Hultdin, M (4); Nilsson, Stefan, 197 ... (3); Akdis, C A (3); Roos, Göran (3); Gronneberg, R (3); Backlin, C (3); Walsh, S (3); Johnson, E. (2); Nilsson, K. (2); Johansson, H (2); Sander, B (2); Korotkov, A (2); Schwarz, A. (2); Dahlen, S (2); Valenta, R (2); Ahlm, C. (2); Juliusson, G (2); Kienle, D. (2); Stilgenbauer, S. (2); Bjorck, E (2); Fiebig, H (2); Dahlen, S. E. (2); Karlsson, Katarina, ... (2); Lindh, J (2); Lonnerholm, G (2); Holmberg, D. (2); Döhner, H. (2); Radovanovic, S (2); Ljubisavljevic, M. (2); Thunberg, T (2); visa färre...

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