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2.
  • Fu, Michael, 1963, et al. (author)
  • Optimizing the Management of Heart Failure with Preserved Ejection Fraction in the Elderly by Targeting Comorbidities (OPTIMIZE-HFPEF).
  • 2016
  • In: Journal of cardiac failure. - : Elsevier BV. - 1532-8414 .- 1071-9164. ; 22:7, s. 539-544
  • Journal article (peer-reviewed)abstract
    • The pathophysiology of heart failure with preserved ejection fraction (HFPEF) is not fully understood. A recently proposed mechanism for HFPEF is that it is a systemic pro-inflammatory state induced by comorbidities, leading to microvascular endothelial dysfunction and subsequent cardiac remodelling and dysfunction. We hypothesize that targeting comorbidities will improve outcomes in elderly patients with HFPEF. Thus, the aim of this study is to determine whether the combination of systematic screening of patients with HFPEF and optimal management of comorbidities associated with HFPEF improves outcomes.
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3.
  • Fu, Michael, 1963, et al. (author)
  • Trends in myocarditis incidence, complications and mortality in Sweden from 2000 to 2014.
  • 2022
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12:1
  • Journal article (peer-reviewed)abstract
    • Investigate trends in myocarditis incidence and prognosis in Sweden during 2000-2014. Little data exist concerning population-trends in incidence of hospitalizations for myocarditis and subsequent prognosis. Linking Swedish National Patient and Cause of Death Registers, we identified individuals≥16years with first-time diagnosis of myocarditis during 2000-2014. Reference population, matched for age and birth year (n=16,622) was selected from Swedish Total Population Register. Among the 8 679 cases (75% men, 64%<50years), incidence rate/100,000 inhabitants rose from 6.3 to 8.6 per 100,000, mostly in men and those<50years. Incident heart failure/dilated cardiomyopathy occurred in 6.2% within 1year after index hospitalization and in 10.2% during 2000-2014, predominantly in those≥50years (12.1% within 1year, 20.8% during 2000-2014). In all 8.1% died within 1year, 0.9% (<50years) and 20.8% (≥50years). Hazard ratios (adjusted for age, sex) for 1-year mortality comparing cases and controls were 4.00 (95% confidence interval 1.37-11.70), 4.48 (2.57-7.82), 4.57 (3.31-6.31) and 3.93 (3.39-4.57) for individuals aged<30, 30 to<50, 50 to<70, and≥70years, respectively. The incidence of myocarditis during 2000-2014 increased, predominantly in men<50years. One-year mortality was low, but fourfold higher compared with reference population.
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4.
  • Ilioudi, Maria, 1993, et al. (author)
  • Patient experience of a virtual reality calm room in a psychiatric inpatient care setting in Sweden: a qualitative study with inpatients
  • 2023
  • In: BMJ open. - 2044-6055. ; 13:12
  • Journal article (peer-reviewed)abstract
    • OBJECTIVE: Calm rooms have been developed and implemented in psychiatric inpatient care settings to offer patients a dedicated space for relaxation in a convenient and safe environment. Recent technology developments have enabled virtual reality (VR) equivalents of calm rooms that can be feasibly deployed in psychiatric care settings. While research has shown VR environments to be efficacious in inducing relaxation, little is known how these virtual calm rooms are perceived by patients. The aim of this study was to elucidate patient experiences of using a VR calm room in a psychiatric inpatient setting. DESIGN: Qualitative interview study. Semi-structured interviews were analysed using qualitive inductive content analysis, which focuses on the interpretation of texts for making replicable and valid inferences. SETTING: Swedish hospital psychiatric inpatient care setting with a wireless, three degrees-of-freedom VR head-mounted display running a calm room application simulating nature environment. PARTICIPANTS: 20 adult patients (12women) with bipolar disorder (n=18) or unipolar depression (n=2). RESULTS: Participants experienced the use of the VR calm room as having a positive impact on them, inducing awareness, calmness and well-being. They were thankful to be offered a non-pharmacological alternative for anxiety relief. Participants also expressed that they had some concerns about how they would react emotionally before using the VR device. However, after use, they highlighted that their overall experience was positive. They also expressed that they could see potential for further development of VR technology in psychiatric care. CONCLUSIONS: VR technology has the potential to solve pressing logistic issues in offering calm rooms in psychiatric inpatient care. VR calm rooms appear to be appreciated by psychiatric inpatients, who value their accessibility, convenience and variety of modalities offered. Participants perceived an increase in their well-being after use.
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5.
  • Ilioudi, Maria, 1993, et al. (author)
  • Physical Versus Virtual Reality-Based Calm Rooms for Psychiatric Inpatients: Quasi-Randomized Trial
  • 2023
  • In: Journal of Medical Internet Research. - : JMIR Publications Inc.. - 1438-8871. ; 25
  • Journal article (peer-reviewed)abstract
    • Background: Interest in sensory rooms or so-called "calm rooms" in psychiatric inpatient care has increased significantly. In a hospital setting, their purpose is to introduce a relaxing environment to increase well-being as well as to decrease anxiety and aggressive behaviors. Calm rooms can also be used as a tool to provide self-help through a convenient environment for the patients and, at the same time, strengthen the therapeutic relationship between the patient and the professional. Recent developments in virtual reality (VR) have made virtual calm rooms possible, but these have not yet been evaluated in psychiatric inpatient care. Objective: This study aimed to compare the effects of VR and physical calm rooms on self-reported well-being and physiological markers of arousal. Methods: The study was conducted in 2 inpatient psychiatric wards specializing in bipolar disorder from March 2019 to February 2021. Patients who were already admitted were asked if they were interested in using a calm room and willing to provide ratings. This study relied on the quasi-randomized allocation of patients to the wards, which either had a physical or VR calm room. Self-assessment scales (Montgomery-Asberg Depression Rating Scale-Self Assessment [MADRS-S], Beck Anxiety Scale, and Clinical Global Impression) were used to determine the participants' baseline level of depressive and anxiety symptoms before their use of the physical or VR calm room. The study determined the state of well-being measured using an 11-point visual analog scale (VAS) as well as arousal measured by blood pressure (systolic and diastolic) and heart rate before and after the use of the calm rooms. The primary end point was self-reported well-being using the VAS. Results: A total of 60 participants were included-40 used the VR calm room and 20 used the physical calm room. The mean age of participants was 39 years and the majority were women (35/60, 58%). Analysis of VAS measurement showed improved well-being at the group level from before to after the intervention (P<.05), with no statistically significant difference in effects between the 2 different interventions. Effects were not moderated by baseline depression levels (dichotomized as MADRS-S >20 or <= 20) despite an overall difference in reported well-being between subgroups. Conclusions: Although the power in this study was low, the findings of this first study indicate comparable effects with respect to well-being and arousal of a VR calm room and a physical calm room. This suggests that a VR calm room can be a viable alternative when the use of a physical calm room is not an option for logistic or other reasons.
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6.
  • Sakalaki, Maria, 1986, et al. (author)
  • Multi-modality biomarkers in the early prediction of ischaemic heart disease in middle-aged men during a 21-year follow-up
  • 2021
  • In: BMC Cardiovascular Disorders. - : Springer Science and Business Media LLC. - 1471-2261. ; 21:1
  • Journal article (peer-reviewed)abstract
    • BackgroundIschaemic heart disease (IHD) often develops after decades of preceding subclinical coronary atherosclerosis. Biomarkers are useful prognostic predictors of IHD, but their long-term predictive value in a general population has not been adequately studied.PurposeTo investigate the early predictive value of multi-modality biomarkers in addition to clinical risk factors in incident IHD in a random male general population sample followed from 50 to 71 years of age.Method"The Study of Men Born in 1943" is a longitudinal cohort study during follow-up. All the men underwent a baseline examination in 1993, where a panel of biomarkers were analysed and incident IHD was registered during 21-year follow-ups.ResultsOf 739 participants, 97 men (13.1%) developed an IHD event. For time to first occurrence of IHD, univariable analyses showed that elevated levels of high sensitivity troponin T (hs-TNT), high sensitivity-C reactive protein (hs-CRP) and interleukin-6 (IL-6) were significant predictors of IHD. In addition, a high number of biomarkers with elevated levels (hs-TNT>10 ng/L, hs-CRP>1 mg/L, IL-6>8 ng/L and N-terminal pro b-type natriuretic peptide (NT-proBNP)>100 pg/mL) increased predictive ability. In univariable and multivariable analysis high-density lipoprotein-cholesterol (HDL-C) had the highest predictive ability. Hs-TNT provided better predictive ability than smoking, body mass index and glucose, and was an independent significant predictor when adjusted for HDL-C, total cholesterol and hypertension. Addition of biomarkers on top of clinical risk factors provided significantly better prediction as tested by likelihood ratio test (p=0.033), but did not significantly enhance the model's discriminative ability However, it appeared contributing to higher sensitivity in the late phase of follow-up.ConclusionIn this random, middle-aged male population sample, the addition of biomarker hs-TNT was an independent significant predictor of IHD and significantly improved prediction, indicating the probability of a better prediction of long-term risk of IHD in a low-risk population.Trial registration: The study is registered at Clinical Trials.gov Identifier number: NCT03138122
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  • Thunström, Maria, et al. (author)
  • Integration of a hand-reared chimpanzee (Pan troglodytes) infant into a social group of conspecifics
  • 2013
  • In: Primates. - : Springer Science and Business Media LLC. - 0032-8332 .- 1610-7365. ; 54:1, s. 13-19
  • Journal article (peer-reviewed)abstract
    • Rejections of infants among non-human primates occasionally occur in the wild as well as in captive settings. Controlled adoptions of orphans and introductions of individuals into new groups are therefore sometimes necessary in captivity. Consequently, behavioral research on integration procedures and on the acceptance of infants by adoptive mothers is much needed. In this study, the introduction and subsequent adoption were examined in an 18-month-old hand-reared chimpanzee (Pan troglodytes). The infant was introduced into an age/sex-diversified social group of conspecifics at Furuvik Zoo, Gavle, Sweden, and continuous focal data was collected during the final stage of integration, including infant care exhibited by the group members and the infant's secure base behavior. The infant was successfully integrated into the group and engaged in positive social interactions with all group members. An adult primiparous female chimpanzee formed a bond resembling a mother-infant relationship with the infant, which continues to be maintained at publication. However, the female initially showed very limited interest in the infant. It was, in fact, two other younger female group members that exhibited most infant care. The infant's secure base behavior patterns indicate that she adapted well to the new circumstances in the chimpanzee group as the integration progressed. This provides evidence that a final adopter does not necessarily initially show maternal interest and that there can be flexibility in maternal behavior in adult chimpanzee females. Moreover, the methods applied employing gradual familiarization with all the group members and the use of an integration enclosure, may have contributed to a successful result. These findings extend our knowledge of introduction procedures in captivity as well as provide information on foster mother-infant attachment in chimpanzees.
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9.
  • Thunström Salzer, Anna, et al. (author)
  • Assessment of Neutrophil Chemotaxis Upon G-CSF Treatment of Healthy Stem Cell Donors and in Allogeneic Transplant Recipients
  • 2018
  • In: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 9
  • Journal article (peer-reviewed)abstract
    • Neutrophils are crucial for the human innate immunity and constitute the majority of leukocytes in circulation. Thus, blood neutrophil counts serve as a measure for the immune system's functionality. Hematological patients often have low neutrophil counts due to disease or chemotherapy. To increase neutrophil counts and thereby preventing infections in high-risk patients, recombinant G-CSF is widely used as adjunct therapy to stimulate the maturation of neutrophils. In addition, G-CSF is utilized to recruit stem cells (SCs) into the peripheral blood of SC donors. Still, the actual functionality of neutrophils resulting from G-CSF treatment remains insufficiently understood. We tested the ex vivo functionality of neutrophils isolated from blood of G-CSF-treated healthy SC donors. We quantified chemotaxis, oxidative burst, and phagocytosis before and after treatment and detected significantly reduced chemotactic activity upon G-CSF treatment. Similarly, in vitro treatment of previously untreated neutrophils with G-CSF led to reduced chemotactic activity. In addition, we revealed that this effect persists in the allogeneic SC recipients up to 4 weeks after neutrophil engraftment. Our data indicates that neutrophil quantity, as a sole measure of immunocompetence in high-risk patients should be considered cautiously as neutrophil functionality might be affected by the primary treatment.
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  • Result 1-9 of 9
Type of publication
journal article (8)
conference paper (1)
Type of content
peer-reviewed (8)
other academic/artistic (1)
Author/Editor
Fu, Michael, 1963 (4)
Thunström, Erik, 198 ... (4)
Schaufelberger, Mari ... (3)
Rosengren, Annika, 1 ... (2)
Björklund, Mats (2)
Persson, Tomas (2)
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Steingrimsson, Stein ... (2)
Ali, Lilas, 1981 (2)
Wallström, Sara, 198 ... (2)
Bollano, Entela, 197 ... (2)
Ilioudi, Maria, 1993 (2)
Osmanovic Thunström, ... (2)
Thunström, Maria (2)
Ahlm, Clas, 1956- (1)
Swedberg, Karl, 1944 (1)
Petzold, Max, 1973 (1)
Urban, Constantin F (1)
Röhm, Marc (1)
Ljungman, Charlotta, ... (1)
Ioannou, Michael (1)
Pivodic, Aldina, 197 ... (1)
Johansson, Viktor, 1 ... (1)
Kontogeorgos, Silvan ... (1)
Johansson, Magnus C, ... (1)
Grote, Ludger, 1964 (1)
Wahlin, Anders (1)
Åström, Fredrik (1)
Andersson, Bert, 195 ... (1)
Lindner, Philip (1)
Hansson, Per-Olof, 1 ... (1)
Lindner, P (1)
Hosseinzadeh, Ava (1)
Zverkova Sandström, ... (1)
Basic, Carmen, 1975 (1)
Henrysson, Josefin (1)
Ermert, David (1)
Falk, Örjan (1)
Hamilton, W (1)
Niemiec, Maria Joann ... (1)
Zhou, Jingmin (1)
Almgren, Torbjörn (1)
Kroon, Christian (1)
Anving, N. (1)
Stylianou, Marios, 1 ... (1)
Sakalaki, Maria, 198 ... (1)
Thunström Salzer, An ... (1)
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University
University of Gothenburg (6)
Lund University (2)
Karolinska Institutet (2)
Umeå University (1)
Uppsala University (1)
Örebro University (1)
Language
English (8)
Swedish (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (7)
Natural sciences (2)
Social Sciences (2)

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