| 1. |
- Engert, Andreas, et al.
(författare)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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Ingår i: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Tidskriftsartikel (refereegranskat)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 2. |
- Harrison, Robert, et al.
(författare)
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Next Generation of Engineering Methods and Tools for SOA-Based Large-Scale and Distributed Process Applications
- 2014
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Ingår i: Industrial Cloud-Based Cyber-Physical Systems. - Cham : Encyclopedia of Global Archaeology/Springer Verlag. - 9783319056234 - 9783319056241 ; , s. 137-165
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Bokkapitel (refereegranskat)abstract
- Engineering methods and tools are seen as key for designing, testing, deploying and operating future infrastructures. They accompany critical processes from ‘cradle-to-grave’. Here we provide an overview of the user and business requirements for engineering tools, including system development, modelling, visualisation, commissioning and change in an SOA engineering environment. An appraisal of existing engineering tools appropriate to IMC-AESOP, both commercial and development prototypes are presented, culminating in the presentation of tool cartography graphically, defining the impact of these tools within the enterprise and system lifecycle.
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| 3. |
- Jammes, François, et al.
(författare)
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Promising Technologies for SOA-Based Industrial Automation Systems
- 2014
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Ingår i: Industrial Cloud-Based Cyber-Physical Systems. - Cham : Encyclopedia of Global Archaeology/Springer Verlag. - 9783319056234 - 9783319056241 ; , s. 89-109
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Bokkapitel (refereegranskat)abstract
- In the last years service-oriented architectures have been extensively used to enable seamless interaction and integration among the various heterogeneous systems and devices found in modern factories. The emerging Industrial Automation Systems are increasingly utilising them. In the cloud-based vision of IMC-AESOP such technologies take an even more key role as they empower the backbone of the new concepts and approaches under development. Here we report about the investigations and assessments performed to find answers to some of the major questions that arise as key when technologies have to be selected and used in an industrial context utilizing Service-Oriented Architecture (SOA)-based distributed large-scale process monitoring and control system. Aspects of integration, real-timeness, distributeness, event-based interaction, service-enablement, etc., are approached from different angles and some of the promising technologies are analysed and assessed.
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| 4. |
- Jammes, Francois, et al.
(författare)
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Technologies for SOA-based distributed large scale process monitoring and control systems
- 2012
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Ingår i: Proceeding IEE IECON 2012. - Montreal : IEEE Communications Society. ; , s. 5803-5808
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Konferensbidrag (refereegranskat)abstract
- In a SOA-based system the applications are organized in a manner such that interoperable services can be used from different domains. In a process industry context, different domains can refer to, for example, process instrumentation and monitoring, execution of process control, data acquisition, etc. Large process industry systems are a complex and potentially very large sets of multi-disciplinary, heterogeneous, networked distributed systems. Current industrial process control systems are typically vendor specific; in addition the different domains are associated with different layers, different standards and different technologies. In the paper the authors report about the investigations and assessments performed to find answers for four major critical questions that arise as key when technologies have to be selected and used in a true Service Oriented Architecture (SOA) based distributed large scale Process Monitoring and Control system: (1) Real-time SOA (what are the limits of bringing SOA into high performance control loops?); (2) Management of large scale industrial distributed control systems (is it feasible to manage up to tens of thousands of service-oriented devices?); (3) Distributed event-based systems are asynchronous (what are the limits compared to traditional periodic scanning systems?) and (4) Service specification (which semantics are the most suitable for specifying process control and monitoring services?).
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| 5. |
- Karnouskos, Stamatis, et al.
(författare)
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A SOA-based architecture for empowering future collaborative cloud-based industrial automation
- 2012
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Ingår i: IECON 2012. - Piscataway, NJ : IEEE Communications Society. - 9781467324212 ; , s. 5770-5775
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Konferensbidrag (refereegranskat)abstract
- The last years we are witnessing of rapid advances in the industrial automation domain, mainly driven by business needs towards agility and supported by new disruptive tech- nologies. Future factories will rely on multi-system interactions and collaborative cross-layer management and automation ap- proaches. Such a factory, configured and managed from archi- tectural and behavioural viewpoints, under the service-oriented architecture (SOA) paradigm is virtualized by services exposed by its key components (both HW and SW). One of the main results of this virtualization is that the factory is transformed into a ”cloud of services”, where dynamic resource allocation and interactions take place. This paper presents a view on such architecture, its specification, the main motivation and considerations, as well as the preliminary services it may need to support.
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| 6. |
- Karnouskos, Stamatis, et al.
(författare)
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The IMC-AESOP architecture for cloud-based industrial Cyber-physical Systems
- 2014
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Ingår i: Industrial Cloud-Based Cyber-Physical Systems. - Cham : Encyclopedia of Global Archaeology/Springer Verlag. - 9783319056234 - 9783319056241 ; , s. 49-88
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Bokkapitel (refereegranskat)abstract
- A coherent architectural framework is needed to be able to cope with the imposed requirements and realise the vision for the industrial automation domain. Future factories will rely on multi-system interactions and collaborative cross-layer management and automation approaches. The service-oriented architecture paradigm empowered by virtualisation of resources acts as a lighthouse. More specifically by integrating Web services, Internet technologies, Cloud systems and the power of the Internet of Things, we can create a framework that has the possibility of empowering seamless integration and interaction among the heterogeneous stakeholders in the future industrial automation domain. We propose here a service architecture that attempts to cover the basic needs for monitoring, management, data handling, integration, etc., by taking into consideration the disruptive technologies and concepts that could empower future industrial systems
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