| 1. |
- Berndt, Sonja, I, et al.
(författare)
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Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
- 2022
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Ingår i: Leukemia. - : Springer Nature. - 0887-6924 .- 1476-5551. ; 36:12, s. 2835-2844
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Tidskriftsartikel (refereegranskat)abstract
- Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.
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| 4. |
- Pinchuk, N. V., et al.
(författare)
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Simulation of the influence of alloying elements on the characteristics of the formation of vacuum-arc nitride coatings
- 2023
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Ingår i: Functional Materials. - : National Academy of Sciences of Ukraine. - 1027-5495. ; 30:4, s. 597-605
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Tidskriftsartikel (refereegranskat)abstract
- An analysis of trends in the interaction of elements of the Periodic Table was carried out and the results obtained were compared with a model material (namely with a TiN coating); predictions were made for structure formation in vacuum-arc nitride coatings and modeling of the properties of the final coating depending on the composition and deposition conditions This made it possible to explain changes in structural characteristics and mechanical properties in the presence of weaker and/or stronger nitride-forming elements in nitride coatings. Under all deposition conditions and different elemental compositions, single-phase crystalline coatings were obtained. The addition of Mo to the coating increases the lattice period of TiMoN. It was es-tablished that the high-entropy coatings (TiVZrNbHf)N and (TiVZrNbHfTa)N are single-phase with an fcc lattice. The high entropy of the system prevents the formation of intermetallic com-pounds. The coatings are polycrystalline with a crystallite size of 20-23 nm. It has been estab-lished that high-entropy coatings obtained at a nitrogen atmosphere pressure of 0.26 Pa and a constant bias potential of -200 V have the highest hardness value of 53-55 GPa. The theoretical model used to analyze the characteristics of high-entropy alloys and nitride coatings based on them has been confirmed experimentally.
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| 5. |
- Tkachuk, Anton, 1986-, et al.
(författare)
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Design of truss structures with multiple eigenfrequency constraints via rank minimization
- 2024
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Ingår i: Computers & structures. - : Elsevier. - 0045-7949 .- 1879-2243. ; 299
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Tidskriftsartikel (refereegranskat)abstract
- Rank deficiency of the dynamic stiffness matrix is an indicator for resonance of a structure at a given frequency. This indicator can be exploited as a heuristic optimization objective to achieve resonance at several frequencies. Log-det heuristic provides a tractable surrogate function for matrix rank in the case of affine dependency of stiffness and mass matrices on design parameters, which applies to truss structures. Reducing the rank of the dynamic stiffness matrix for higher frequencies implies that the matrix is not semi-positive definite. For this case, the log-det heuristic is valid with a combination of interior-point methods and Fazel’s semi-definite embedding via linear matrix inequalities. Further constraints on the fundamental frequency and compliance can be easily added within the framework as linear matrix inequalities. Several successful numerical examples illustrate the performance of the approach.
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| 6. |
- Tkachuk, M. M., et al.
(författare)
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Large deformation of cable networks with fiber sliding as a second-order cone programming
- 2024
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Ingår i: International Journal of Solids and Structures. - : Elsevier. - 0020-7683 .- 1879-2146. ; 298
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Tidskriftsartikel (refereegranskat)abstract
- A new model for irreversible large deformations of fiber networks is developed. The fibers are considered as inextensible cables that slide relative to each other in the frictional junctions. This sliding is constituted by a rate-independent flow rule. The nonsmooth dissipation potential for each sliding system is defined as a product of the yield strength and the absolute value of the fiber sliding. The response of the cable segments is nonsmooth as well, since it shows asymmetry with respect to tension and compression. A principle of minimum incremental potential and a pure complementary energy principle are derived for the equilibrium incremental loading of the network at large deformations. They form a pair of primal and dual second-order cone programming problems with matching sets of displacement-based and force-based variables. These problems can be effectively solved by interior point methods that have many advantages compared to the gradient-based methods or dynamic relaxation. The model is extended by a simple mechanism of fiber pull-out resulting from fiber sliding at the free unconstrained ends. This can be used for the microstructural analysis of failure of needle-punched nonwoven materials.
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| 8. |
- Jönsson, Petra, et al.
(författare)
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Absence of conventional spin-glass transition in the Ising dipolar system LiHo(x)Y(1-x)F(4)
- 2007
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 98:25, s. 256403-
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Tidskriftsartikel (refereegranskat)abstract
- The magnetic properties of single crystals of LiHo(x)Y(1-x)F(4) with x=16.5% and x=4.5% were recorded down to 35 mK using a micro-SQUID magnetometer. While this system is considered as the archetypal quantum spin glass, the detailed analysis of our magnetization data indicates the absence of a phase transition, not only in a transverse applied magnetic field, but also without field. A zero-Kelvin phase transition is also unlikely, as the magnetization seems to follow a noncritical exponential dependence on the temperature. Our analysis thus unmasks the true, short-ranged nature of the magnetic properties of the LiHo(x)Y(1-x)F(4) system, validating recent theoretical investigations suggesting the lack of phase transition in this system.
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