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Sökning: WFRF:(Tobelem Jean Michel)

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1.
  • Van de Veire, Sara, et al. (författare)
  • Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease
  • 2010
  • Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 141:1, s. 178-190
  • Tidskriftsartikel (refereegranskat)abstract
    • Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of carcinogen-induced and transgenic tumor models as well as ocular neovascularization to report further evidence in support of our original findings of PlGF as a promising target for anticancer therapies. We present evidence for the efficacy of additional anti-PlGF antibodies and their ability to phenocopy genetic deficiency or silencing of PlGF in cancer and ocular disease but also show that not all anti-PlGF antibodies are effective. We also provide additional evidence for the specificity of our anti-PlGF antibody and experiments to suggest that anti-PlGF treatment will not be effective for all tumors and why. Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies.
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2.
  • Pauget, Bertrand, et al. (författare)
  • Between Museum and Health Care : An Example of the Successful Creation, Implementation, and Diffusion of Organizational Innovations
  • 2019
  • Ingår i: Journal of Innovation Economics & Management. - Louvain la Neuve : DE BOECK UNIV. - 2352-6645 .- 2032-5355. ; :30, s. 145-161
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper presents how a museum can create, implement and disseminate a series of organizational innovations. We attempt to describe these phenomena in terms of the social structure. We believe that coherence with the social structure is one of the keys to implementing and disseminating organizational innovation. We emphasize the role of relations and transformational leadership. Our case study is the Montreal Museum of Fine Arts. This museum has proposed a rapprochement with the health sector to the point of offering dedicated spaces for people who are suffering from various pathologies. The results show a connection between wellbeing promoted by the museum and health carried out by health professionals.
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