| 1. |
- Kraus, V. B., et al.
(författare)
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Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis
- 2011
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Ingår i: Osteoarthritis and Cartilage. - : Elsevier BV. - 1063-4584. ; 19:5, s. 515-542
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Osteoarthritis (OA) is a chronic and slowly progressive disease for which biomarkers may be able to provide a more rapid indication of therapeutic responses to therapy than is currently available; this could accelerate and facilitate OA drug discovery and development programs. The goal of this document is to provide a summary and guide to the application of in vitro (biochemical and other soluble) biomarkers in the development of drugs for OA and to outline and stimulate a research agenda that will further this goal. Methods: The Biomarkers Working Group representing experts in the field of OA biomarker research from both academia and industry developed this consensus document between 2007 and 2009 at the behest of the Osteoarthritis Research Society International Federal Drug Administration initiative (OARSI FDA initiative). Results: This document summarizes definitions and classification systems for biomarkers, the current outcome measures used in OA clinical trials, applications and potential utility of biomarkers for development of OA therapeutics, the current state of qualification of OA-related biomarkers, pathways for biomarker qualification, critical needs to advance the use of biomarkers for drug development, recommendations regarding practices and clinical trials, and a research agenda to advance the science of OA-related biomarkers. Conclusions: Although many OA-related biomarkers are currently available they exist in various states of qualification and validation. The biomarkers that are likely to have the earliest beneficial impact on clinical trials fall into two general categories, those that will allow targeting of subjects most likely to either respond and/or progress (prognostic value) within a reasonable and manageable time frame for a clinical study (for instance within 1-2 years for an OA trial), and those that provide early feedback for preclinical decision-making and for trial organizers that a drug is having the desired biochemical effect. As in vitro biomarkers are increasingly investigated in the context of specific drug treatments, advances in the field can be expected that will lead to rapid expansion of the list of available biomarkers with increasing understanding of the molecular processes that they represent. (C) 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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| 2. |
- Pnevmatikatos, Dionisios N., et al.
(författare)
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FASTER: Facilitating analysis and synthesis technologies for effective reconfiguration
- 2012
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Ingår i: 15th Euromicro Conference on Digital System Design, DSD 2012; Cesme, Izmir; Turkey; 5 September 2012 through 8 September 2012. - 9780769547985 ; , s. 234-241
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Konferensbidrag (refereegranskat)abstract
- The FASTER project aims to ease the definition, implementation and use of dynamically changing hardware systems. Our motivation stems from the promise reconfigurable systems hold for achieving better performance and extending product functionality and lifetime via the addition of new features that work at hardware speed. This is a clear advantage over the more straightforward software component adaptivity. However, designing a changing hardware system is both challenging and time consuming. The FASTER project will facilitate the use of reconfigurable technology by providing a complete methodology that enables designers to easily specify, analyse, implement and verify applications on platforms with general-purpose processors and acceleration modules implemented in the latest reconfigurable technology. To better adapt to different application requirements, the tool-chain will support both region-based and micro-reconfiguration and provide a flexible run-time system that will efficiently manage the reconfigurable resources. We will use applications from the embedded, high performance computing, and desktop domains to demonstrate the potential benefits of the FASTER tools on metrics such as performance, power consumption and total ownership cost.
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| 3. |
- Papadimitriou, Kyprianos D., et al.
(författare)
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Novel design methods and a tool flow for unleashing dynamic reconfiguration
- 2012
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Ingår i: 15th IEEE International Conference on Computational Science and Engineering, CSE 2012 and 10th IEEE/IFIP International Conference on Embedded and Ubiquitous Computing, EUC 2012, Paphos, 5 through 7 December 2012. - 9780769549149 ; , s. 391-398
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Konferensbidrag (refereegranskat)abstract
- During the last few years, there is an increasing interest in mixing software and hardware to serve efficiently different applications. This is due to the heterogeneity characterizing the tasks of an application which require the presence of resources from both worlds, software and hardware. Controlling effectively these resources through an integrated tool flow is a challenging problem and towards this direction only a few efforts exist. In fact, a framework that seamlessly exploits both resources of a platform for executing efficiently an application has not yet come into existence. Moreover, reconfigurable computing often incorporated in such platforms due to its high flexibility and customization, has not yet taken off due to the lack of exploiting its full capabilities. Thus, the capability of reconfigurable devices such as Field Programmable Gate Arrays (FPGAs) to be dynamically reconfigured, i.e. reprogramming part of the chip while other parts of the same chip remain functional, has not yet taken off even in small-scale basis. The inherent difficulty in using the tools to control this technology has kept it back from being adopted by academia and industry alike. The FASTER (Facilitating Analysis and Synthesis Technologies for Effective Reconfiguration) project aims at introducing a design methodology and a tool flow that will enable designers to implement effectively and easily a system specification on a platform combining software and reconfigurable resources. The FASTER framework accepts as input a high-level description of the application and the architectural details of the target platform, and through certain steps it can enable the full use of the capabilities of the platform, while at the same time it should be flexible enough so as to balance efficiently performance, power and area. One of the main novelties is the incorporation of partial reconfiguration as an explicit design concept at an early stage of the design flow. We target different applications from the embedded, desktop and high-performance computing domains. In all cases we will demonstrate the effectiveness of the proposed framework in exploiting the inherent parallelism of applications and enabling the runtime adaptation of the platforms to the changing needs of the applications.
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| 4. |
- Pnevmatikatos, Dionisios N., et al.
(författare)
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FASTER: Facilitating Analysis and Synthesis Technologies for Effective Reconfiguration
- 2015
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Ingår i: Microprocessors and Microsystems. - : Elsevier BV. - 0141-9331. ; 39:4-5, s. 321-338
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Tidskriftsartikel (refereegranskat)abstract
- The FASTER (Facilitating Analysis and Synthesis Technologies for Effective Reconfiguration) EU FP7 project, aims to ease the design and implementation of dynamically changing hardware systems. Our motivation stems from the promise reconfigurable systems hold for achieving high performance and extending product functionality and lifetime via the addition of new features that operate at hardware speed. However, designing a changing hardware system is both challenging and time-consuming. FASTER facilitates the use of reconfigurable technology by providing a complete methodology enabling designers to easily specify, analyze, implement and verify applications on platforms with general-purpose processors and acceleration modules implemented in the latest reconfigurable technology. Our tool-chain supports both coarse- and fine-grain FPGA reconfiguration, while during execution a flexible run-time system manages the reconfigurable resources. We target three applications from different domains. We explore the way each application benefits from reconfiguration, and then we asses them and the FASTER tools, in terms of performance, area consumption and accuracy of analysis.
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| 5. |
- Santambrogio, M. D., et al.
(författare)
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Smart technologies for effective reconfiguration: The FASTER approach
- 2012
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Ingår i: ReCoSoC 2012 - 7th International Workshop on Reconfigurable and Communication-Centric Systems-on-Chip, Proceedings. - 9781467325721
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Konferensbidrag (refereegranskat)abstract
- Current and future computing systems increasingly require that their functionality stays flexible after the system is operational, in order to cope with changing user requirements and improvements in system features, i.e. changing protocols and data-coding standards, evolving demands for support of different user applications, and newly emerging applications in communication, computing and consumer electronics. Therefore, extending the functionality and the lifetime of products requires the addition of new functionality to track and satisfy the customers needs and market and technology trends. Many contemporary products along with the software part incorporate hardware accelerators for reasons of performance and power efficiency. While adaptivity of software is straightforward, adaptation of the hardware to changing requirements constitutes a challenging problem requiring delicate solutions. The FASTER (Facilitating Analysis and Synthesis Technologies for Effective Reconfiguration) project aims at introducing a complete methodology to allow designers to easily implement a system specification on a platform which includes a general purpose processor combined with multiple accelerators running on an FPGA, taking as input a high-level description and fully exploiting, both at design time and at run time, the capabilities of partial dynamic reconfiguration. The goal is that for selected application domains, the FASTER toolchain will be able to reduce the design and verification time of complex reconfigurable systems providing additional novel verification features that are not available in existing tool flows.
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