| 1. |
- Alexander, Stephen P. H., et al.
(författare)
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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
- 2023
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Ingår i: BRITISH JOURNAL OF PHARMACOLOGY. - : British pharmacological society. - 0007-1188 .- 1476-5381. ; 180
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Tidskriftsartikel (refereegranskat)abstract
- The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at . G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
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| 2. |
- Börstler, Jürgen, 1960-, et al.
(författare)
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Developers talking about code quality
- 2023
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Ingår i: Empirical Software Engineering. - : Springer. - 1382-3256 .- 1573-7616. ; 28:6
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Tidskriftsartikel (refereegranskat)abstract
- There are many aspects of code quality, some of which are difficult to capture or to measure. Despite the importance of software quality, there is a lack of commonly accepted measures or indicators for code quality that can be linked to quality attributes. We investigate software developers’ perceptions of source code quality and the practices they recommend to achieve these qualities. We analyze data from semi-structured interviews with 34 professional software developers, programming teachers and students from Europe and the U.S. For the interviews, participants were asked to bring code examples to exemplify what they consider good and bad code, respectively. Readability and structure were used most commonly as defining properties for quality code. Together with documentation, they were also suggested as the most common target properties for quality improvement. When discussing actual code, developers focused on structure, comprehensibility and readability as quality properties. When analyzing relationships between properties, the most commonly talked about target property was comprehensibility. Documentation, structure and readability were named most frequently as source properties to achieve good comprehensibility. Some of the most important source code properties contributing to code quality as perceived by developers lack clear definitions and are difficult to capture. More research is therefore necessary to measure the structure, comprehensibility and readability of code in ways that matter for developers and to relate these measures of code structure, comprehensibility and readability to common software quality attributes.
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| 3. |
- Börstler, Jürgen, et al.
(författare)
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I know it when I see it : Perceptions of Code Quality ITiCSE'17 Working Group Report
- 2017
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Ingår i: ITICSE-WGR'17: PROCEEDINGS OF THE 2017 ITICSE CONFERENCE WORKING GROUP REPORTS. - New York, NY, USA : ACM Digital Library. - 9781450347044 ; , s. 70-85
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Konferensbidrag (refereegranskat)abstract
- Context. Code quality is a key issue in software development. The ability to develop high quality software is therefore a key learning goal of computing programs. However, there are no universally accepted measures to assess the quality of code and current standards are considered weak. Furthermore, there are many facets to code quality. Defining and explaining the concept of code quality is therefore a challenge faced by many educators.Objectives. In this working group, we investigated code quality as perceived by students, educators, and professional developers, in particular, the differences in their views of code quality and which quality aspects they consider as more or less important. Furthermore, we investigated their sources for information about code quality and its assessment.Methods. We interviewed 34 students, educators and professional developers regarding their perceptions of code quality. For the interviews they brought along code from their own experience to discuss and exemplify code quality.Results. There was no common definition of code quality among or within these groups. Quality was mostly described in terms of indicators that could measure an aspect of code quality. Among these indicators, readability was named most frequently by all groups. The groups showed significant differences in the sources they use for learning about code quality with education ranked lowest in all groups.Conclusions. Code quality should be discussed more thoroughly in educational programs.
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| 4. |
- Börstler, Jürgen, et al.
(författare)
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"I know it when I see it" : perceptions of code quality
- 2017
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Ingår i: ITiCSE '17: Proceedings of the 2017 ACM Conference on Innovation and Technology in Computer Science Education. - New York, NY, USA : Association for Computing Machinery (ACM). - 9781450347044 ; , s. 389-389
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Konferensbidrag (refereegranskat)abstract
- Code quality is a key issue in software development. The ability to develop software of high quality is therefore a key learning goal of computing programs. However, there are no universally accepted measures to assess the quality of code and current standards are consideredweak. Furthermore, there are many facets to code quality. Defining and explaining the concept of code quality is therefore a challenge faced by many educators. In this working group, we investigate the perceptions of code quality of students, teachers, and professional programmers. In particular, we are interested in the differences in views of code quality by students, educators, and professional programmers and which quality aspects they consider as more or less important. Furthermore, we are interested in which sources of information on code quality and its assessment are used by these groups. Eventually, this will help us to develop resources that can be used to broaden students' views on software quality.
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| 5. |
- Börstler, Jürgen, et al.
(författare)
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"I know it when I see it" - Perceptions of Code Quality ITiCSE'17 Working Group Report
- 2018
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Ingår i: ITICSE-WGR'17. - New York, NY, USA : ACM Publications. ; , s. 70-85
-
Konferensbidrag (refereegranskat)abstract
- Context. Code quality is a key issue in software development. The ability to develop high quality software is therefore a key learning goal of computing programs. However, there are no universally accepted measures to assess the quality of code and current standards are considered weak. Furthermore, there are many facets to code quality. Defining and explaining the concept of code quality is therefore a challenge faced by many educators. Objectives. In this working group, we investigated code quality as perceived by students, educators, and professional developers, in particular, the differences in their views of code quality and which quality aspects they consider as more or less important. Furthermore, we investigated their sources for information about code quality and its assessment. Methods. We interviewed 34 students, educators and professional developers regarding their perceptions of code quality. For the interviews they brought along code from their own experience to discuss and exemplify code quality. Results. There was no common definition of code quality among or within these groups. Quality was mostly described in terms of indicators that could measure an aspect of code quality. Among these indicators, readability was named most frequently by all groups. The groups showed significant differences in the sources they use for learning about code quality with education ranked lowest in all groups. Conclusions. Code quality should be discussed more thoroughly in educational programs.
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| 6. |
- Carlsson, Allan, 1979-
(författare)
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Orientation of fibres in suspensions flowing over a solid surface
- 2007
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The orientation of fibres suspended in a viscous fluid, flowing over a solid surface, has been studied experimentally. A shear layer was generated, by letting the suspension flow down an inclined plate. Far upstream from the measuring section the suspension was accelerated to obtain an initial orientation of the fibres aligned with the flow direction. A CCD-camera was used to visualise the fibres. The velocity profile of the fibres coincided with the theoretical expression for fully developed flow of Newtonian liquid down an inclined wall. The orientation of the fibres was analysed in planes parallel to the solid surface. At distances from the wall larger than one fibre length the fibres performed a tumbling motion in the flow-gradient plane in what appeared to be Jeffery-like orbits. Closer to the wall a difference was found between fibres of aspect ratio rp = 10 and 40. The longer fibres of rp = 40 kept their orientation, aligned with the flow, also in the near wall region. For the shorter fibres the orientation shifted gradually, to orientations closer to the vorticity axis, when the distance from the wall was decreased. In the very proximity to the wall the fibres were aligned with the vorticity, perpendicular to the direction of the flow. Another distinction, most likely related to the fibre orientation, was seen in the wall normal concentration profile. Due to sedimentation effects fibres accumulated in the near wall region. For fibres of rp = 10 a peak in concentration was found at the wall, while for r=40 the maximum concentration was found approximately half a fibre length from the wall. It is previously known that a fibre can interact with the wall in what is referred to as a "pole vaulting" motion away from the wall. It is suggested, as a likely explanation to the location of the maximum concentration, that fibres of rp = 40 perform this motion, while fibres of rp=10 do not. In another experiment the surface of the wall was modified with ridges. For fibres of rp = 10 there were no longer any fibres oriented perpendicular to the flow direction in the near wall region. The main application in mind throughout this work is papermaking. The study is considered to be of fundamental character and is not applicable in a direct sense. The difference between the flow situation in the experiments and the paper machine is discussed further.
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| 7. |
- Ericsson, Morgan, et al.
(författare)
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A Study of the Effect of Data Normalization on Software and Information Quality Assessment
- 2013
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Ingår i: Software Engineering Conference (APSEC, 2013 20th Asia-Pacific). - : IEEE Press. - 9781479921430 ; , s. 55-60
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Konferensbidrag (refereegranskat)abstract
- Indirect metrics in quality models define weighted integrations of direct metrics to provide higher-level quality indicators. This paper presents a case study that investigates to what degree quality models depend on statistical assumptions about the distribution of direct metrics values when these are integrated and aggregated. We vary the normalization used by the quality assessment efforts of three companies, while keeping quality models, metrics, metrics implementation and, hence, metrics values constant. We find that normalization has a considerable impact on the ranking of an artifact (such as a class). We also investigate how normalization affects the quality trend and find that normalizations have a considerable effect on quality trends. Based on these findings, we find it questionable to continue to aggregate different metrics in a quality model as we do today.
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| 8. |
- Hansson, L. S., et al.
(författare)
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Perception of unfamiliar caregivers during sickness - Using the new Caregiver Perception Task (CgPT) during experimental endotoxemia
- 2024
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Ingår i: Brain, behavior, and immunity. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0889-1591 .- 1090-2139. ; 119, s. 741-749
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Tidskriftsartikel (refereegranskat)abstract
- Social withdrawal is a well-established part of sickness behavior, but in some contexts sick animals might gain from keeping close instead of keeping away. For instance, sick individuals are more willing to be near known individuals who can provide care and safety (close others) compared to when healthy. Yet, interactions with some strangers might also be beneficial (i.e., healthcare professionals), but it is not known how sickness interplay with social behavior towards such individuals. Here, we assessed if sickness affects perception of caregivers, and developed a new task, the Caregiver Perception Task (CgPT). Twenty-six participants performed the CgPT, once after an injection of lipopolysaccharide (LPS, 0.8 ng/kg body weight, n = 24), and once after an injection of saline (n = 25), one hour and forty-five minutes post-injection. During the task, participants watched short video clips of three types of caregivers: a healthcare professional taking care of a sick individual, a healthcare professional not taking care of a sick individual, and a non-healthcare professional taking care of their sick adult child or partner. After each video clip, the likability, trustworthiness, professionalism, and willingness to interact with and receive care from the caregiver were rated on visual analogue scales. Results showed that participants injected with saline rated healthcare professionals who did not take care of a sick individual less positively on all aspects compared to healthcare professionals who took care of a sick individual. Moreover, compared to saline, LPS increased the participants' willingness to receive care from healthcare professionals and non-healthcare professionals providing care, but not from healthcare professionals not providing care. Thus, our results indicate that sick individuals may approach unknown individuals with potential to provide care and support.
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| 9. |
- Hansson, Lina S., 1992-, et al.
(författare)
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Perception of unfamiliar caregivers during sickness – Using the new Caregiver Perception Task (CgPT) during experimental endotoxemia
- 2024
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Ingår i: Brain, behavior, and immunity. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0889-1591 .- 1090-2139. ; 119, s. 741-749
-
Tidskriftsartikel (refereegranskat)abstract
- Social withdrawal is a well-established part of sickness behavior, but in some contexts sick animals might gain from keeping close instead of keeping away. For instance, sick individuals are more willing to be near known individuals who can provide care and safety (close others) compared to when healthy. Yet, interactions with some strangers might also be beneficial (i.e., healthcare professionals), but it is not known how sickness interplay with social behavior towards such individuals. Here, we assessed if sickness affects perception of caregivers, and developed a new task, the Caregiver Perception Task (CgPT). Twenty-six participants performed the CgPT, once after an injection of lipopolysaccharide (LPS, 0.8 ng/kg body weight, n = 24), and once after an injection of saline (n = 25), one hour and forty-five minutes post-injection. During the task, participants watched short video clips of three types of caregivers: a healthcare professional taking care of a sick individual, a healthcare professional not taking care of a sick individual, and a non-healthcare professional taking care of their sick adult child or partner. After each video clip, the likability, trustworthiness, professionalism, and willingness to interact with and receive care from the caregiver were rated on visual analogue scales. Results showed that participants injected with saline rated healthcare professionals who did not take care of a sick individual less positively on all aspects compared to healthcare professionals who took care of a sick individual. Moreover, compared to saline, LPS increased the participants’ willingness to receive care from healthcare professionals and non-healthcare professionals providing care, but not from healthcare professionals not providing care. Thus, our results indicate that sick individuals may approach unknown individuals with potential to provide care and support.
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| 10. |
- Henricson, Joakim, et al.
(författare)
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Diffuse Reflectance Spectroscopy : Getting the Capillary Refill Test Under Ones Thumb
- 2017
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Ingår i: Journal of Visualized Experiments. - : MyJove Corporation. - 1940-087X. ; :130
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Tidskriftsartikel (refereegranskat)abstract
- The capillary refill test was introduced in 1947 to help estimate circulatory status in critically ill patients. Guidelines commonly state that refill should occur within 2 s after releasing 5 s of firm pressure (e.g., by the physicians finger) in the normal healthy supine patient. A slower refill time indicates poor skin perfusion, which can be caused by conditions including sepsis, blood loss, hypoperfusion, and hypothermia. Since its introduction, the clinical usefulness of the test has been debated. Advocates point out its feasibility and simplicity and claim that it can indicate changes in vascular status earlier than changes in vital signs such as heart rate. Critics, on the other hand, stress that the lack of standardization in how the test is performed and the highly subjective nature of the naked eye assessment, as well as the tests susceptibility to ambient factors, markedly lowers the clinical value. The aim of the present work is to describe in detail the course of the refill event and to suggest potentially more objective and exact endpoint values for the capillary refill test using diffuse polarization spectroscopy.
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