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- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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- Ballesteros, Joaquin, et al.
(författare)
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A cane-based low cost sensor to implement attention mechanisms in telecare robots
- 2019
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Ingår i: 2019 International Conference on Robotics and Automation (ICRA). - : Institute of Electrical and Electronics Engineers Inc.. - 9781538660263 ; , s. 1473-1478
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Konferensbidrag (refereegranskat)abstract
- Telepresence robots have been recently used for Comprehensive Geriatric Assessment (CGA). Since the robot can not track a person continuously, there are several strategies to decide when to check them, from cyclic checks to simple requests from users and/or caregivers. In order to adapt to the user needs and condition, it is preferable to perform CGA as soon as regularities appear. However, this requires detection of potential issues in users to offer immediate service. In this work we propose a new low cost force sensor system to detect user's condition and attract attention of CGA robots, so they can perform a full examination on a need basis. The main advantages of this system are: i) it can be attached to any standard commercial cane; ii) its power consumption is very reduced; and iii) it provides continuous information as long as the user walks. It has been tested with several elderly volunteers in care facilities. Results have proven that the sensor readings are indeed correlated with the users' condition.
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- Ballesteros, Joaquin, et al.
(författare)
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Weight-Bearing Estimation for Cane Users by Using Onboard Sensors
- 2019
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Ingår i: Sensors. - : NLM (Medline). - 1424-8220. ; 19:3
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Tidskriftsartikel (refereegranskat)abstract
- Mobility is a fundamental requirement for a healthy, active lifestyle. Gait analysis is widely acknowledged as a clinically useful tool for identifying problems with mobility, as identifying abnormalities within the gait profile is essential to correct them via training, drugs, or surgical intervention. However, continuous gait analysis is difficult to achieve due to technical limitations, namely the need for specific hardware and constraints on time and test environment to acquire reliable data. Wearables may provide a solution if users carry them most of the time they are walking. We propose to add sensors to walking canes to assess user's mobility. Canes are frequently used by people who cannot completely support their own weight due to pain or balance issues. Furthermore, in absence of neurological disorders, the load on the cane is correlated with the user condition. Sensorized canes already exist, but often rely on expensive sensors and major device modifications are required. Thus, the number of potential users is severely limited. In this work, we propose an affordable module for load monitoring so that it can be widely used as a screening tool. The main advantages of our module are: (i) it can be deployed in any standard cane with minimal changes that do not affect ergonomics; (ii) it can be used every day, anywhere for long-term monitoring. We have validated our prototype with 10 different elderly volunteers that required a cane to walk, either for balance or partial weight bearing. Volunteers were asked to complete a 10 m test and, then, to move freely for an extra minute. The load peaks on the cane, corresponding to maximum support instants during the gait cycle, were measured while they moved. For validation, we calculated their gait speed using a chronometer during the 10 m test, as it is reportedly related to their condition. The correlation between speed (condition) and load results proves that our module provides meaningful information for screening. In conclusion, our module monitors support in a continuous, unsupervised, nonintrusive way during users' daily routines, plus only mechanical adjustment (cane height) is needed to change from one user to another.
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- Ribera, J., et al.
(författare)
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Increased nitric oxide production in lymphatic endothelial cells causes impairment of lymphatic drainage in cirrhotic rats
- 2013
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Ingår i: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 62:1, s. 138-145
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Tidskriftsartikel (refereegranskat)abstract
- Background and aim: The lymphatic network plays a major role in maintaining tissue fluid homoeostasis. Therefore several pathological conditions associated with oedema formation result in deficient lymphatic function. However, the role of the lymphatic system in the pathogenesis of ascites and oedema formation in cirrhosis has not been fully clarified. The aim of this study was to investigate whether the inability of the lymphatic system to drain tissue exudate contributes to the oedema observed in cirrhosis. Methods: Cirrhosis was induced in rats by CCl4 inhalation. Lymphatic drainage was evaluated using fluorescent lymphangiography. Expression of endothelial nitric oxide synthase (eNOS) was measured in primary lymphatic endothelial cells (LyECs). Inhibition of eNOS activity in cirrhotic rats with ascites (CH) was carried out by L-N G-methyl-L-arginine (L-NMMA) treatment (0.5 mg/kg/day). Results: The (CH) rats had impaired lymphatic drainage in the splanchnic and peripheral regions compared with the control (CT) rats. LyECs isolated from the CH rats showed a significant increase in eNOS and nitric oxide (NO) production. In addition, the lymphatic vessels of the CH rats showed a significant reduction in smooth muscle cell (SMC) coverage compared with the CT rats. CH rats treated with L-NMMA for 7 days showed a significant improvement in lymphatic drainage and a significant reduction in ascites volume, which were associated with increased plasma volume. This beneficial effect of L-NMMA inhibition was also associated with a significant increase in lymphatic SMC coverage. Conclusions: The upregulation of eNOS in the LyECs of CH rats causes long-term lymphatic remodelling, which is characterised by a loss of SMC lymphatic coverage. The amelioration of this lymphatic abnormality by chronic eNOS inhibition results in improved lymphatic drainage and reduced ascites.
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