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Träfflista för sökning "WFRF:(Tuo S) "

Sökning: WFRF:(Tuo S)

  • Resultat 1-4 av 4
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1.
  • Aad, G, et al. (författare)
  • 2015
  • swepub:Mat__t
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2.
  • 2019
  • Tidskriftsartikel (refereegranskat)
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3.
  • Hoshino, Ayuko, et al. (författare)
  • Tumour exosome integrins determine organotropic metastasis
  • 2015
  • Ingår i: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 527:7578, s. 329-
  • Tidskriftsartikel (refereegranskat)abstract
    • Ever since Stephen Pagets 1889 hypothesis, metastatic organotropism has remained one of cancers greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver-and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics revealed distinct integrin expression patterns, in which the exosomal integrins alpha(6)beta(4) and alpha(6)beta(1) were associated with lung metastasis, while exosomal integrin alpha(v)beta(5) was linked to liver metastasis. Targeting the integrins alpha(6)beta(4) and alpha(v)beta(5) decreased exosome uptake, as well as lung and liver metastasis, respectively. We demonstrate that exosome integrin uptake by resident cells activates Src phosphorylation and pro-inflammatory S100 gene expression. Finally, our clinical data indicate that exosomal integrins could be used to predict organ-specific metastasis.
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4.
  • Nabizadeh, Armin, et al. (författare)
  • Spectral evolution of X-ray pulsar 4U 1901+03 during the 2019 outburst based on Insight-HXMT and NuSTAR observations
  • 2021
  • Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 652
  • Tidskriftsartikel (refereegranskat)abstract
    • We report on a detailed spectral analysis of emission from X-ray pulsar 4U 1901+03 using data obtained by the Insight-HXMT and NuSTAR observatories during the 2019 outburst of the source. Thanks to the extensive coverage of the outburst by Insight-HXMT, we were able to investigate the spectral evolution of the source as a function of flux, and compare these results to the previous reports, focusing on the properties of a putative absorption feature at around 10 keV. In particular, we demonstrate that the broadband X-ray continuum of 4U 1901+03 can be well described with a two-component continuum model without an absorption line at 10 keV, which casts doubt on its interpretation as a cyclotron line. The high quality of the data also allowed us to perform both phase-averaged and phase-resolved spectral analyses as a function of luminosity. Finally, we performed a detailed investigation of another absorption feature in the spectrum of the source around 30 keV recently reported in the NuSTAR data. We show that this feature appears to be significantly detected both in phase-averaged and phase-resolved spectra irrespective of the continuum model.
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  • Resultat 1-4 av 4

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