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Tidskriftsartikel (refereegranskat)
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- Klausner, A P, et al.
(författare)
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The role of corticotropin releasing factor and its antagonist, astressin, on micturition in the rat
- 2005
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Ingår i: Autonomic Neuroscience: Basic & Clinical. - : Elsevier BV. - 1872-7484. ; 123:1-2, s. 26-35
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this investigation was to evaluate the role of corticotropin releasing factor (CRF) on micturition. CRF is involved in the endocrine and central nervous system responses to stress and is also expressed in sites responsible for the control of micturition. In this investigation, cystometric experiments were performed in awake and unrestrained Wistar rats and on Spontaneous Hypertensive Rats, which are used as a rodent model of detrusor overactivity and anxiety. In vitro effects of CRF were evaluated using strips of detrusor muscle in an organ bath preparation. CRF (6.0 mu g) administered via intrathecal and intraperitoneal routes, but not intracerebroventricularly, lowered the micturition threshold. CRF reduced the intercontraction interval by 28% and 26% after intrathecal or intraperitoneal administration, respectively, and reduced micturition volume by 34.7% and 30.2%, respectively. In Wistar-Kyoto rats, 6.0 mu g intrathecal CRF significantly reduced intercontraction interval (423 +/- 79 vs. 669 +/- 59s) and micturition volume (0.30 +/- 0.04 vs. 0.69 +/- 0.07 ml) compared to controls that received saline vehicle. These effects were blocked by pretreatment with 6.0 mu g intrathecal astressin, a potent CRF antagonist, demonstrating that the effects are CRF receptor mediated. In Spontaneous Hypertensive Rats, 6.0 mu G intrathecal CRF was found to have minimal stimulatory effects on the bladder, whereas astressin reduced baseline detrusor overactivity. CRF had no direct contractile effects on detrusor muscle strips. These results demonstrate that in the absence of detrusor overactivity, CRE stimulates micturition when administered via the intrathecal or intraperitoneal routes. Further studies are needed to explore the possibility whether CRF antagonists are effective for detrusor overactivity and the overactive bladder syndrome.
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- Schlatter, Nicola Manuel, et al.
(författare)
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Auroral ion acoustic wave enhancement observed with a radar interferometer system
- 2015
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Ingår i: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 33:7, s. 837-844
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of naturally enhanced ion acoustic line (NEIAL) echoes obtained with a five-antenna interferometric imaging radar system are presented. The observations were conducted with the European Incoherent SCATter (EIS-CAT) radar on Svalbard and the EISCAT Aperture Synthesis Imaging receivers (EASI) installed at the radar site. Four baselines of the interferometer are used in the analysis. Based on the coherence estimates derived from the measurements, we show that the enhanced backscattering region is of limited extent in the plane perpendicular to the geomagnetic field. Previously it has been argued that the enhanced backscatter region is limited in size; however, here the first unambiguous observations are presented. The size of the enhanced backscatter region is determined to be less than 900 x 500 m, and at times less than 160m in the direction of the longest antenna separation, assuming the scattering region to have a Gaussian scattering cross section in the plane perpendicular to the geomagnetic field. Using aperture synthesis imaging methods volumetric images of the NEIAL echo are obtained showing the enhanced backscattering region to be aligned with the geomagnetic field. Although optical auroral emissions are observed outside the radar look direction, our observations are consistent with the NEIAL echo occurring on field lines with particle precipitation.
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