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1.	Waning, DL, et al. (author) Excess TGF-β mediates muscle weakness associated with bone metastases in mice 2015 In: Nature medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 21:11, s. 1262-1271 Journal article (peer-reviewed)
2.	Umanskaya, A, et al. (author) C. Elegans as a Model to Study Ryanodine Receptor Function in Aging 2014 In: BIOPHYSICAL JOURNAL. - : Elsevier BV. - 0006-3495. ; 106:2, s. 111A-111A Conference paper (other academic/artistic)
3.	Umanskaya, A, et al. (author) Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging 2014 In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 111:42, s. 15250-15255 Journal article (peer-reviewed)abstract Age-related muscle weakness has major adverse consequences on quality of life, increasing the risk of falls, fractures, and movement impairments. Albeit an increased oxidative state has been shown to contribute to age-dependent reduction in skeletal muscle function, little is known about the mechanisms connecting oxidation and muscle weakness. We show here that genetically enhancing mitochondrial antioxidant activity causes improved skeletal muscle function and voluntary exercise in aged mice. Our findings have broad implications for both the aging and muscle physiology fields, as we present an important molecular mechanism for muscle weakness in aging and skeletal muscle force regulation.

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Type of publication: journal article (2); conference paper (1)

Type of content: peer-reviewed (2); other academic/artistic (1)

Author/Editor: Umanskaya, A (3); Reiken, S (2); Xie, WJ (2); Marks, AR (2); Wang, X. (1); Cao, X. (1); show more...; aut (1); Wronska, A. (1); Andersson, D (1); Andersson, DC (1); John, S (1); Trivedi, T. (1); Haynes, A. (1); Waning, DL (1); Benassi, MS (1); Mohammad, KS (1); Chiechi, A (1); Wright, LE (1); Niewolna, M (1); Charkhzarrin, S (1); Khatiwada, P (1); Witzmannt, FA (1); Zhen, GH (1); Roodman, GD (1); Guise, TA (1); show less...

University: Karolinska Institutet (3)

Language: English (3)

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