| 1. |
- Bascom, Karen E., et al.
(författare)
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Derivation and validation of the CREST model for very early prediction of circulatory etiology death in patients without ST-segment-elevation myocardial infarction after cardiac arrest
- 2018
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Ingår i: Circulation. - 0009-7322. ; 137:3, s. 273-282
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: No practical tool quantitates the risk of circulatory-etiology death (CED) immediately after successful cardiopulmonary resuscitation in patients without ST-segment-elevation myocardial infarction. We developed and validated a prediction model to rapidly determine that risk and facilitate triage to individualized treatment pathways. METHODS: With the use of INTCAR (International Cardiac Arrest Registry), an 87-question data set representing 44 centers in the United States and Europe, patients were classified as having had CED or a combined end point of neurological-etiology death or survival. Demographics and clinical factors were modeled in a derivation cohort, and backward stepwise logistic regression was used to identify factors independently associated with CED. We demonstrated model performance using area under the curve and the Hosmer-Lemeshow test in the derivation and validation cohorts, and assigned a simplified point-scoring system. RESULTS: Among 638 patients in the derivation cohort, 121 (18.9%) had CED. The final model included preexisting coronary artery disease (odds ratio [OR], 2.86; confidence interval [CI], 1.83-4.49; P≤0.001), nonshockable rhythm (OR, 1.75; CI, 1.10-2.77; P=0.017), initial ejection fraction<30% (OR, 2.11; CI, 1.32-3.37; P=0.002), shock at presentation (OR, 2.27; CI, 1.42-3.62; P<0.001), and ischemic time >25 minutes (OR, 1.42; CI, 0.90-2.23; P=0.13). The derivation model area under the curve was 0.73, and Hosmer-Lemeshow test P=0.47. Outcomes were similar in the 318-patient validation cohort (area under the curve 0.68, Hosmer-Lemeshow test P=0.41). When assigned a point for each associated factor in the derivation model, the average predicted versus observed probability of CED with a CREST score (coronary artery disease, initial heart rhythm, low ejection fraction, shock at the time of admission, and ischemic time >25 minutes) of 0 to 5 was: 7.1% versus 10.2%, 9.5% versus 11%, 22.5% versus 19.6%, 32.4% versus 29.6%, 38.5% versus 30%, and 55.7% versus 50%. CONCLUSIONS: The CREST model stratified patients immediately after resuscitation according to risk of a circulatory-etiology death. The tool may allow for estimation of circulatory risk and improve the triage of survivors of cardiac arrest without ST-segment-elevation myocardial infarction at the point of care.
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| 2. |
- Gopakumar, Geethanjali, 1992-, et al.
(författare)
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X-ray Induced Fragmentation of Protonated Cystine
- 2022
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Ingår i: Journal of Physical Chemistry A. - : American Chemical Society (ACS). - 1089-5639 .- 1520-5215. ; 126:9, s. 1496-1503
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate site-specific X-ray induced fragmentation across the sulfur L-edge of protonated cystine, the dimer of the amino acid cysteine. Ion yield NEXAFS were performed in the gas phase using electrospray ionization (ESI) in combination with an ion trap. The interpretation of the sulfur L-edge NEXAFS spectrum is supported by Restricted Open-Shell Configuration Interaction (ROCIS) calculations. The fragmentation pathway of triply charged cystine ions was modeled by Molecular Dynamics (MD) simulations. We have deduced a possible pathway of fragmentation upon excitation and ionization of S 2p electrons. The disulfide bridge breaks for resonant excitation at lower photon energies but remains intact upon higher energy resonant excitation and upon ionization of S 2p. The larger fragments initially formed subsequently break into smaller fragments.
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| 3. |
- Hajisharif, Saghi, et al.
(författare)
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Single Sensor Compressive Light Field Video Camera
- 2020
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Ingår i: Computer graphics forum (Print). - : Wiley-Blackwell. - 0167-7055 .- 1467-8659. ; 39:2, s. 463-474
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a novel compressed sensing (CS) algorithm and camera design for light field video capture using a single sensor consumer camera module. Unlike microlens light field cameras which sacrifice spatial resolution to obtain angular information, our CS approach is designed for capturing light field videos with high angular, spatial, and temporal resolution. The compressive measurements required by CS are obtained using a random color-coded mask placed between the sensor and aperture planes. The convolution of the incoming light rays from different angles with the mask results in a single image on the sensor; hence, achieving a significant reduction on the required bandwidth for capturing light field videos. We propose to change the random pattern on the spectral mask between each consecutive frame in a video sequence and extracting spatioangular- spectral-temporal 6D patches. Our CS reconstruction algorithm for light field videos recovers each frame while taking into account the neighboring frames to achieve significantly higher reconstruction quality with reduced temporal incoherencies, as compared with previous methods. Moreover, a thorough analysis of various sensing models for compressive light field video acquisition is conducted to highlight the advantages of our method. The results show a clear advantage of our method for monochrome sensors, as well as sensors with color filter arrays.
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| 4. |
- Hellmark, Thomas, et al.
(författare)
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Identification of a clinically relevant immunodominant region of collagen IV in Goodpasture disease
- 1999
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Ingår i: Kidney International. - : Elsevier BV. - 1523-1755 .- 0085-2538. ; 55:3, s. 936-944
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive glomerulonephritis, with or without lung hemorrhage, whereas autoantibodies specific for the other alpha chains of the heterotrimeric type IV collagen probably do not cause disease. In this study, we have investigated whether differences in fine specificity of autoimmune recognition of the alpha3(IV)NC1 correlate with clinical outcome. METHODS: For mapping of antibody binding to type IV collagen, chimeric collagen constructs were generated in which parts of the alpha3(IV)NC1 domain were replaced by the corresponding sequences of homologous nonreactive alpha1(IV). The different recombinant collagen chimeras allowed the analysis of antibody specificities in 77 sera from well-documented patients. RESULTS: One construct that harbors the aminoterminal third of the alpha3(IV)NC1 was recognized by all sera, indicating that it represents the dominant target of the B-cell response in Goodpasture disease. Seventy percent of the samples recognized other parts of the molecule as well. However, only reactivity to the N-terminus of the alpha3(IV)NC1 correlated with prognosis, that is, kidney survival after six months of follow-up. CONCLUSION: The results indicate the crucial importance of antibody recognition of this particular domain for the pathogenesis of Goodpasture disease, thereby opening new avenues for the development of better diagnostic and therapeutic procedures.
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| 5. |
- Markt, Sarah C., et al.
(författare)
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ABO Blood Group Alleles and Prostate Cancer Risk : results from the Breast and Prostate Cancer Cohort Consortium (BPC3)
- 2015
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Ingår i: The Prostate. - : John Wiley & Sons. - 0270-4137 .- 1097-0045. ; 75:15, s. 1677-1681
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND. ABO blood group has been associated with risk of cancers of the pancreas, stomach, ovary, kidney, and skin, but has not been evaluated in relation to risk of aggressive prostate cancer. METHODS. We used three single nucleotide polymorphisms (SNPs) (rs8176746, rs505922, and rs8176704) to determine ABO genotype in 2,774 aggressive prostate cancer cases and 4,443 controls from the Breast and Prostate Cancer Cohort Consortium (BPC3). Unconditional logistic regression was used to calculate age and study-adjusted odds ratios and 95% confidence intervals for the association between blood type, genotype, and risk of aggressive prostate cancer (Gleason score >= 8 or locally advanced/metastatic disease (stage T3/T4/N1/M1). RESULTS. We found no association between ABO blood type and risk of aggressive prostate cancer (Type A: OR = 0.97, 95% CI = 0.87-1.08; Type B: OR = 0.92, 95% CI = n0.77-1.09; Type AB: OR = 1.25, 95% CI = 0.98-1.59, compared to Type O, respectively). Similarly, there was no association between "dose" of A or B alleles and aggressive prostate cancer risk. CONCLUSIONS. ABO blood type was not associated with risk of aggressive prostate cancer. Prostate 75: 1677-1681, 2015. (C) 2015 Wiley Periodicals, Inc.
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| 6. |
- Miandji, Ehsan, et al.
(författare)
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Compressive HDR Light Field Imaging Using a Single Multi-ISO Sensor
- 2021
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Ingår i: IEEE Transactions on Computational Imaging. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 2573-0436 .- 2333-9403. ; 7, s. 1369-1384
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we propose a new design for single sensor compressive HDR light field cameras, combining multi-ISO photography with coded mask acquisition, placed in a compressive sensing framework. The proposed camera model is based on a main lens, a multi-ISO sensor and a coded mask located in the optical path between the main lens and the sensor that projects the coded spatio-angular information of the light field onto the 2D sensor. The model encompasses different acquisition scenarios with different ISO patterns and gains. Moreover, we assume that the sensor has a built-in color filter array (CFA), making our design more suitable for consumer-level cameras. We propose a reconstruction algorithm to jointly perform color demosaicing, light field angular information recovery, HDR reconstruction, and denoising from the multi-ISO measurements formed on the sensor. This is achieved by enabling the sparse representation of HDR light fields using an overcomplete HDR dictionary. We also provide two HDR light field data sets: one synthetic data set created using the Blender rendering software with two baselines, and a real light field data set created from the fusion of multi-exposure low dynamic range (LDR) images captured using a Lytro Illum light field camera. Experimental results show that, with a sampling rate as low as 2.67%, using two shots, our proposed method yields a higher light field reconstruction quality compared to the fusion of multiple LDR light fields captured with different exposures, and with the fusion of multiple LDR light fields captured with different ISO settings.
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| 7. |
- Miandji, Ehsan, et al.
(författare)
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Multi-Shot Single Sensor Light Field Camera Using a Color Coded Mask
- 2018
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Ingår i: 2018 26TH EUROPEAN SIGNAL PROCESSING CONFERENCE (EUSIPCO). - : IEEE COMPUTER SOC. - 9789082797015 ; , s. 226-230
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Konferensbidrag (refereegranskat)abstract
- We present a compressed sensing framework for reconstructing the full light field of a scene captured using a single-sensor consumer camera. To achieve this, we use a color coded mask in front of the camera sensor. To further enhance the reconstruction quality, we propose to utilize multiple shots by moving the mask or the sensor randomly. The compressed sensing framework relies on a training based dictionary over a light field data set. Numerical simulations show significant improvements in reconstruction quality over a similar coded aperture system for light field capture.
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| 8. |
- Tongbuasirilai, Tanaboon, et al.
(författare)
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A Sparse Non-parametric BRDF Model
- 2022
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Ingår i: ACM Transactions on Graphics. - : ASSOC COMPUTING MACHINERY. - 0730-0301 .- 1557-7368. ; 41:5
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a novel sparse non-parametric Bidirectional Reflectance Distribution Function (BRDF) model derived using a machine learning approach to represent the space of possible BRDFs using a set of multidimensional sub-spaces, or dictionaries. By training the dictionaries under a sparsity constraint, the model guarantees high-quality representations with minimal storage requirements and an inherent clustering of the BDRF-space. The model can be trained once and then reused to represent a wide variety of measured BRDFs. Moreover, the proposed method is flexible to incorporate new unobserved data sets, parameterizations, and transformations. In addition, we show that any two, or more, BRDFs can be smoothly interpolated in the coefficient space of the model rather than the significantly higher-dimensional BRDF space. The proposed sparse BRDF model is evaluated using the MERL, DTU, and RGL-EPFL BRDF databases. Experimental results show that the proposed approach results in about 9.75dB higher signal-to-noise ratio on average for rendered images as compared to current state-of-the-art models.
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| 9. |
- Valero-Esquitino, Verónica, et al.
(författare)
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Direct angiotensin type 2 receptor (AT2R) stimulation attenuates T-cell and microglia activation and prevents demyelination in experimental autoimmune encephalomyelitis in mice
- 2015
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Ingår i: Clinical Science. - 0143-5221 .- 1470-8736. ; 128:2, s. 95-109
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Tidskriftsartikel (refereegranskat)abstract
- In the present study, we evaluated stimulation of the angiotensin type 2 receptor (AT2R) by the selective non-peptide agonist Compound 21 (C21) as a novel therapeutic concept for the treatment of multiple sclerosis using the model of experimental autoimmune encephalomyelitis (EAE) in mice. C57BL-6 mice were immunized with myelin-oligodendrocyte peptide and treated for 4 weeks with C21 (0.3 mg/kg/day i.p.). Potential effects on myelination, microglia and T-cell composition were estimated by immunostaining and FACS analyses of lumbar spinal cords. The in vivo study was complemented by experiments in aggregating brain cell cultures and microglia in vitro. In the EAE model, treatment with C21 ameliorated microglia activation and decreased the number of total T-cells and CD4+ T-cells in the spinal cord. Fluorescent myelin staining of spinal cords further revealed a significant reduction in EAE-induced demyelinated areas in lumbar spinal cord tissue after AT2R stimulation. C21-treated mice had a significantly better neurological score than vehicle-treated controls. In aggregating brain cell cultures challenged with lipopolysaccharide (LPS) plus interferon-γ (IFNγ), AT2R stimulation prevented demyelination, accelerated re-myelination and reduced the number of microglia. Cytokine synthesis and nitric oxide production by microglia in vitro were significantly reduced after C21 treatment. These results suggest that AT2R stimulation protects the myelin sheaths in autoimmune central nervous system inflammation by inhibiting the T-cell response and microglia activation. Our findings identify the AT2R as a potential new pharmacological target for demyelinating diseases such as multiple sclerosis.
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