| 1. |
- Bous, J, et al.
(författare)
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Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex
- 2022
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Ingår i: Science advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 8:35, s. eabo7761-
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Tidskriftsartikel (refereegranskat)abstract
- Arrestins interact with G protein–coupled receptors (GPCRs) to stop G protein activation and to initiate key signaling pathways. Recent structural studies shed light on the molecular mechanisms involved in GPCR-arrestin coupling, but whether this process is conserved among GPCRs is poorly understood. Here, we report the cryo–electron microscopy active structure of the wild-type arginine-vasopressin V2 receptor (V2R) in complex with β-arrestin1. It reveals an atypical position of β-arrestin1 compared to previously described GPCR-arrestin assemblies, associated with an original V2R/β-arrestin1 interface involving all receptor intracellular loops. Phosphorylated sites of the V2R carboxyl terminus are clearly identified and interact extensively with the β-arrestin1 N-lobe, in agreement with structural data obtained with chimeric or synthetic systems. Overall, these findings highlight a notable structural variability among GPCR-arrestin signaling complexes.
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| 2. |
- Chang, Jin, et al.
(författare)
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Efficient mid-infrared single-photon detection using superconducting NbTiN nanowires with high time resolution in a Gifford-McMahon cryocooler
- 2022
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Ingår i: Photonics Research. - : Optica Publishing Group. - 2327-9125. ; 10:4, s. 1063-1070
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Tidskriftsartikel (refereegranskat)abstract
- Shortly after their inception, superconducting nanowire single-photon detectors (SNSPDs) became the leading quantum light detection technology. With the capability of detecting single-photons with near-unity efficiency, high time resolution, low dark count rate, and fast recovery time, SNSPDs outperform conventional single-photon detection techniques. However, detecting lower energy single photons (<0.8 eV) with high efficiency and low timing jitter has remained a challenge. To achieve unity internal efficiency at mid-infrared wavelengths, previous works used amorphous superconducting materials with low energy gaps at the expense of reduced time resolution (close to a nanosecond), and by operating them in complex milliKelvin (mK) dilution refrigerators. In this work, we provide an alternative approach with SNSPDs fabricated from 5 to 9.5 nm thick NbTiN superconducting films and devices operated in conventional Gifford-McMahon cryocoolers. By optimizing the superconducting film deposition process, film thickness, and nanowire design, our fiber-coupled devices achieved >70% system detection efficiency (SDE) at 2 mu m and sub-15 ps timing jitter. Furthermore, detectors from the same batch demonstrated unity internal detection efficiency at 3 mu m and 80% internal efficiency at 4 mu m, paving the road for an efficient mid-infrared single-photon detection technology with unparalleled time resolution and without mK cooling requirements. We also systematically studied the dark count rates (DCRs) of our detectors coupled to different types of mid-infrared optical fibers and blackbody radiation filters. This offers insight into the trade-off between bandwidth and DCRs for mid-infrared SNSPDs. To conclude, this paper significantly extends the working wavelength range for SNSPDs made from polycrystalline NbTiN to 1.5-4 mu m, and we expect quantum optics experiments and applications in the mid-infrared range to benefit from this far-reaching technology. Published by Chinese Laser Press under the terms of the Creative Commons Attribution 4.0 License.
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| 3. |
- Lu, Xingyuan, et al.
(författare)
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Phase detection of coherence singularities and determination of the topological charge of a partially coherent vortex beam
- 2019
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Ingår i: Applied Physics Letters. - : American Institute of Physics (AIP). - 0003-6951 .- 1077-3118. ; 114:20
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Tidskriftsartikel (refereegranskat)abstract
- In the theory of partial coherence, coherence singularities can occur in the spectral degree of coherence (SDOC): in case the fields at two different points are completely uncorrelated, the phase of the SDOC is undefined. For a partially coherent vortex beam, the detection of coherence singularities is linked to the measurement of topological charge, whose magnitude equals the number of ring dislocations in its far field amplitude. However, the phase distribution of coherence singularities is rarely mentioned in the literature and the amplitude distribution can hardly reflect the sign of topological charge. In this letter, we present a phase-analysis method for measuring the coherence singularities by introducing a movable perturbation at a certain point in an illumination window of a finite size. Using the proposed method, we measure experimentally the coherence singularities of a partially coherent vortex beam in the focal plane. From the results, the magnitude and sign of the topological charge can be determined simultaneously from the phase distribution of the coherence singularities. Our results can find application in information transmission.
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