| 1. |
- Vagianos, Constantin, et al.
(författare)
-
Control of traumatic liver hemorrhage in the cirrhotic rat by intraportal infusion of norepinephrine
- 1987
-
Ingår i: Research in Experimental Medicine. - 0300-9130. ; 187:5, s. 339-346
-
Tidskriftsartikel (refereegranskat)abstract
- The effect of intraportal infusion of norepinephrine (NE) on primary hemostasis in the cirrhotic rat was investigated at standardized liver trauma. Cirrhosis was induced by simultaneous administration of increasing amounts of carbontetrachloride (CCl4) and phenobarbitone. Infusion of norepinephrine took place after cannulation of the gastroduodenal vein. Intraportal infusion of NE resulted in a significant increase in arterial blood pressure and portal pressure in all animals. No difference was observed between cirrhotic and control rats. Cirrhotic animals bled longer and more profusely as compared with the controls. Infusion of NE resulted in significant decrease in bleeding time and blood loss. NE did not affect hematocrit, hemoglobin, platelet, or white cell count. Platelet aggregation was not influenced by the compound. In conclusion, intraportal infusion of NE proved effective in decreasing hemorrhage at liver trauma in cirrhotic rats.
|
|
| 2. |
|
|
| 3. |
- Vagianos, Constantin, et al.
(författare)
-
Increased uptake of 5-FU in experimental liver tumours by simultaneous infusion of norepinephrine
- 1987
-
Ingår i: European journal of cancer & clinical oncology. - : Elsevier BV. - 0277-5379. ; 23:9, s. 1323-1327
-
Tidskriftsartikel (refereegranskat)abstract
- The effect of the simultaneous administration of norepinephrine and 5-fluorouracil (5-FU) on the uptake of radiolabelled 5-FU by liver tumours was studied in rats. Three different concentrations of 5-FU were used (15, 1.5 and 0.15 microgram/g body weight). The drugs were infused over a 30 min period via the hepatic artery, following cannulation of the gastroduodenal artery. The radioactivity in liver tumour, normal liver, lungs and intestines was estimated by liquid scintillation counting. At all concentrations tested, an increased uptake of radioactive 5-FU was found in the tumour when norepinephrine was infused. Tumour/liver ratios also increased significantly in all these cases. No significant differences were noted between norepinephrine infused and control animals in the radioactivity in normal liver, lungs and intestines. The effects noted were possibly due to changes in blood flow within the liver, but the possibility of a direct effect of norepinephrine on DNA metabolism is discussed.
|
|
