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| 2. |
- Matabuena, Marcos, et al.
(författare)
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Identification of Asthma Phenotypes in the Spanish MEGA Cohort Study Using Cluster Analysis
- 2023
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Ingår i: Archivos de Bronconeumologia. - : Elsevier BV. - 0300-2896. ; 59:4, s. 223-231
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: The definition of asthma phenotypes has not been fully established, neither there are cluster studies showing homogeneous results to solidly establish clear phenotypes. The purpose of this study was to develop a classification algorithm based on unsupervised cluster analysis, identifying clusters that represent clinically relevant asthma phenotypes that may share asthma-related outcomes. Methods: We performed a multicentre prospective cohort study, including adult patients with asthma (N = 512) from the MEGA study (Mechanisms underlying the Genesis and evolution of Asthma). A standardised clinical history was completed for each patient. Cluster analysis was performed using the kernel k-groups algorithm. Results: Four clusters were identified. Cluster 1 (31.5% of subjects) includes adult-onset atopic patients with better lung function, lower BMI, good asthma control, low ICS dose, and few exacerbations. Cluster 2 (23.6%) is made of adolescent-onset atopic asthma patients with normal lung function, but low adherence to treatment (59% well-controlled) and smokers (48%). Cluster 3 (17.1%) includes adult-onset patients, mostly severe non-atopic, with overweight, the worse lung function and asthma control, and receiving combination of treatments. Cluster 4 (26.7%) consists of the elderly-onset patients, mostly female, atopic (64%), with high BMI and normal lung function, prevalence of smokers and comorbidities. Conclusion: We defined four phenotypes of asthma using unsupervised cluster analysis. These clusters are clinically relevant and differ from each other as regards FEV1, age of onset, age, BMI, atopy, asthma severity, exacerbations, control, social class, smoking and nasal polyps.
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| 3. |
- Abdallah, Jalal, et al.
(författare)
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Study of energy response and resolution of the ATLAS Tile Calorimeter to hadrons of energies from 16 to 30 GeV
- 2021
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 81:6
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Tidskriftsartikel (refereegranskat)abstract
- Three spare modules of the ATLAS Tile Calorimeter were exposed to test beams from the Super Proton Synchrotron accelerator at CERN in 2017. The detector’s measurements of the energy response and resolution to positive pions and kaons, and protons with energies ranging from 16 to 30 GeV are reported. The results have uncertainties of a few percent. They were compared to the predictions of the Geant4-based simulation program used in ATLAS to estimate the response of the detector to proton-proton events at the Large Hadron Collider. The determinations obtained using experimental and simulated data agree within the uncertainties.
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| 4. |
- Canet, Albert, et al.
(författare)
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Exploring substrate specificities of a recombinant Rhizopus oryzae lipase in biodiesel synthesis
- 2017
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Ingår i: New Biotechnology. - : Elsevier BV. - 1871-6784. ; 39, s. 59-67
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Tidskriftsartikel (refereegranskat)abstract
- The alcoholysis of triolein was used to explore the specific features of a recombinant Rhizopus oryzae lipase (rROL) for biodiesel synthesis. For this purpose, different acylglycerols were compared as substrates in lipase-catalysed transesterification. rROL was shown to exhibit a higher specificity towards 1-monoolein than triolein compared to other R. oryzae lipases, being more than 4-fold more specific; in contrast, rROL did not accept 2-monoolein as substrate, concluding that it is highly 1,3-positional specific. Comparing ethanol and methanol as acyl-acceptors, it was observed that the latter caused more lipase inactivation. Regarding alcohols, it was also demonstrated that acyl migration occurred in moderate alcohol concentrations.
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| 5. |
- Surribas, Anna, et al.
(författare)
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Production of a Rhizopus oryzae lipase from Pichia pastoris using alternative operational strategies
- 2007
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Ingår i: Journal of Biotechnology. - : Elsevier BV. - 0168-1656 .- 1873-4863. ; 130:3, s. 291-299
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Tidskriftsartikel (refereegranskat)abstract
- Different cultivation strategies have been compared for the production of Rhizopus oryzae lipase (ROL) from Pichia pastoris. Several drawbacks have been found using a methanol non-limited fed-batch. On the one hand, oxygen limitation appeared at early cell dry weights and, on the other hand, high cell death was observed. A temperature limited fed-batch has been proposed to solve both problems. However, in our case study a methanol non-limited fed-batch results in better productivities. Finally, a lower salt medium were used to overcome cell death problems and a temperature limited fed-batch was applied thereafter to solve oxygen transfer limitations. This combined strategy has resulted in lower productivities when compared to a methanol non-limited fed-batch. However the culture could be longer prolonged and a 1.3-fold purer final product was obtained mainly due to cell death reduction.
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| 6. |
- Valero, Paola, Professor, 1971-, et al.
(författare)
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La educación matemática y la dignidad de estar siendo
- 2022
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Ingår i: Revista de Educación Matemática. - 0326-8780 .- 1852-2890. ; 37:3, s. 38-59
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Tidskriftsartikel (refereegranskat)abstract
- A partir de nuestro trabajo como investigadores, formadores de docentes y profesores comprometidos con un enfoque sociopolítico en la educación matemática en Colombia, proponemos entender la democracia en términos de la posibilidad de construir una subjetividad social para la dignidad de estar siendo. Abordamos el dilema de cómo, históricamente, la inserción de la matemática escolar en relación con el proyecto colonial de asimilación de los pueblos indígenas latinoamericanos a la episteme de la Ilustración y la Modernidad entra en conflicto con la posibilidad de fomentar una subjetividad social en las aulas de matemática. Ejemplificamos una posibilidad pedagógica de avanzar hacia una educación matemática para la subjetividad social con nuestro trabajo al rearticular la noción de espacio geométrico en el plan de estudios de matemática en la secundaria de Colombia con las nociones de espacio de la geografía crítica y el problema de la territorialización, y laepistemología latinoamericana con la noción del espacio íntimo como elemento importante de la subjetividad social.
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