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- Tahmasian, Masoud, et al.
(author)
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ENIGMA-Sleep : Challenges, opportunities, and the road map
- 2021
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In: Journal of Sleep Research. - : Wiley. - 0962-1105 .- 1365-2869. ; 30:6
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Research review (peer-reviewed)abstract
- Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including modest sample sizes, heterogeneous clinical characteristics and varied methodologies. These issues call for a large-scale multi-centre effort in sleep research, in order to increase the number of samples, and harmonize the methods of data collection, preprocessing and analysis using pre-registered well-established protocols. The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium provides a powerful collaborative framework for combining datasets across individual sites. Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding the neurobiology of impaired sleep quality in population-based healthy individuals, the neural consequences of sleep deprivation, pathophysiology of sleep disorders, as well as neural correlates of sleep disturbances across various neuropsychiatric disorders. In this introductory review, we describe the details of our currently available datasets and our ongoing projects in the ENIGMA-Sleep group, and discuss both the potential challenges and opportunities of a collaborative initiative in sleep medicine.
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| 2. |
- Arendt, Josephine, et al.
(author)
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Clinical update : melatonin and sleep disorders.
- 2008
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In: Clin Med. - : Royal College of Physicians. - 1470-2118 .- 1473-4893. ; 8:4, s. 381-3
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Journal article (peer-reviewed)abstract
- Clinical update: melatonin and sleep disorders.Arendt J, Van Someren EJ, Appleton R, Skene DJ, Akerstedt T.Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford. j.arendt@surrey.ac.ukThe hormone melatonin is increasingly used for the treatment of certain sleep disorders, particularly those related to disturbed biological rhythms. This article summarises current knowledge of its mechanism of action and identifies situations where there is good evidence for its efficacy. The authors provide advice, based on their own experience and consistent published data, concerning the dose range of melatonin to be used and the critically important question of the timing of treatment. Anecdotal evidence for the use of melatonin needs to be replaced by data from well-controlled, preferably multi-centre, randomised clinical trials.
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| 3. |
- Axelsson, John, et al.
(author)
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Beauty sleep : experimental study on the perceived health and attractiveness of sleep deprived people
- 2010
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In: The BMJ. - : BMJ. - 1756-1833. ; 341
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Journal article (peer-reviewed)abstract
- Our findings show that sleep deprived people appear less healthy, less attractive, and more tired compared with when they are well rested. This suggests that humans are sensitive to sleep related facial cues, with potential implications for social and clinical judgments and behaviour. Studies are warranted for understanding how these effects may affect clinical decision making and can add knowledge with direct implications in a medical context.
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| 4. |
- Sundelin, Tina, et al.
(author)
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Cues of fatigue : effects of sleep deprivation on facial appearance
- 2013
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In: Sleep. - : Oxford University Press (OUP). - 0161-8105 .- 1550-9109. ; 36:9, s. 1355-1360
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Journal article (peer-reviewed)abstract
- STUDY OBJECTIVE: To investigate the facial cues by which one recognizes that someone is sleep deprived versus not sleep deprived.DESIGN: Experimental laboratory study.SETTING: Karolinska Institutet, Stockholm, Sweden.PARTICIPANTS: Forty observers (20 women, mean age 25 ± 5 y) rated 20 facial photographs with respect to fatigue, 10 facial cues, and sadness. The stimulus material consisted of 10 individuals (five women) photographed at 14:30 after normal sleep and after 31 h of sleep deprivation following a night with 5 h of sleep.MEASUREMENTS: Ratings of fatigue, fatigue-related cues, and sadness in facial photographs.RESULTS: The faces of sleep deprived individuals were perceived as having more hanging eyelids, redder eyes, more swollen eyes, darker circles under the eyes, paler skin, more wrinkles/fine lines, and more droopy corners of the mouth (effects ranging from b = +3 ± 1 to b = +15 ± 1 mm on 100-mm visual analog scales, P < 0.01). The ratings of fatigue were related to glazed eyes and to all the cues affected by sleep deprivation (P < 0.01). Ratings of rash/eczema or tense lips were not significantly affected by sleep deprivation, nor associated with judgements of fatigue. In addition, sleep-deprived individuals looked sadder than after normal sleep, and sadness was related to looking fatigued (P < 0.01).CONCLUSIONS: The results show that sleep deprivation affects features relating to the eyes, mouth, and skin, and that these features function as cues of sleep loss to other people. Because these facial regions are important in the communication between humans, facial cues of sleep deprivation and fatigue may carry social consequences for the sleep deprived individual in everyday life.
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