| 1. |
- Lipzig, Nicole P.M.van, et al.
(author)
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Representation of precipitation and top-of-atmosphere radiation in a multi-model convection-permitting ensemble for the Lake Victoria Basin (East-Africa)
- 2023
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In: Climate Dynamics. - : Springer Science and Business Media LLC. - 0930-7575 .- 1432-0894. ; 60:11-12, s. 4033-4054
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Journal article (peer-reviewed)abstract
- The CORDEX Flagship Pilot Study ELVIC (climate Extremes in the Lake VICtoria basin) was recently established to investigate how extreme weather events will evolve in this region of the world and to provide improved information for the climate impact community. Here we assess the added value of the convection-permitting scale simulations on the representation of moist convective systems over and around Lake Victoria. With this aim, 10 year present-day model simulations were carried out with five regional climate models at both PARameterized (PAR) scales (12–25 km) and Convection-Permitting (CP) scales (2.5–4.5 km), with COSMO-CLM, RegCM, AROME, WRF and UKMO. Most substantial systematic improvements were found in metrics related to deep convection. For example, the timing of the daily maximum in precipitation is systematically delayed in CP compared to PAR models, thereby improving the agreement with observations. The large overestimation in the total number of rainy events is alleviated in the CP models. Systematic improvements were found in the diurnal cycle in Top-Of-Atmosphere (TOA) radiation and in some metrics for precipitation intensity. No unanimous improvement nor deterioration was found in the representation of the spatial distribution of total rainfall and the seasonal cycle when going to the CP scale. Furthermore, some substantial biases in TOA upward radiative fluxes remain. Generally our analysis indicates that the representation of the convective systems is strongly improved in CP compared to PAR models, giving confidence that the models are valuable tools for studying how extreme precipitation events may evolve in the future in the Lake Victoria basin and its surroundings.
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| 2. |
- Morlighem, Camille, et al.
(author)
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The Multi-Satellite Environmental and Socioeconomic Predictors of Vector-Borne Diseases in African Cities : Malaria as an Example
- 2022
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In: Remote Sensing. - : MDPI AG. - 2072-4292. ; 14:21
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Journal article (peer-reviewed)abstract
- Remote sensing has been used for decades to produce vector-borne disease risk maps aiming at better targeting control interventions. However, the coarse and climatic-driven nature of these maps largely hampered their use in the fight against malaria in highly heterogeneous African cities. Remote sensing now offers a large panel of data with the potential to greatly improve and refine malaria risk maps at the intra-urban scale. This research aims at testing the ability of different geospatial datasets exclusively derived from satellite sensors to predict malaria risk in two sub-Saharan African cities: Kampala (Uganda) and Dar es Salaam (Tanzania). Using random forest models, we predicted intra-urban malaria risk based on environmental and socioeconomic predictors using climatic, land cover and land use variables among others. The combination of these factors derived from different remote sensors showed the highest predictive power, particularly models including climatic, land cover and land use predictors. However, the predictive power remained quite low, which is suspected to be due to urban malaria complexity and malaria data limitations. While huge improvements have been made over the last decades in terms of remote sensing data acquisition and processing, the quantity and quality of epidemiological data are not yet sufficient to take full advantage of these improvements.
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| 3. |
- Unnikrishnan, Ashwin, et al.
(author)
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A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network
- 2016
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In: Nucleic Acids Research. - : Oxford University Press (OUP). - 1362-4962 .- 0305-1048. ; 44:22, s. 10644-10661
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Journal article (peer-reviewed)abstract
- Aberrant stem cell-like gene regulatory networks are a feature of leukaemogenesis. The ETS-related gene (ERG), an important regulator of normal haematopoiesis, is also highly expressed in T-ALL and acute myeloid leukaemia (AML). However, the transcriptional regulation of ERG in leukaemic cells remains poorly understood. In order to discover transcriptional regulators of ERG, we employed a quantitative mass spectrometry-based method to identify factors binding the 321 bp ERG +85 stem cell enhancer region in MOLT-4 T-ALL and KG-1 AML cells. Using this approach, we identified a number of known binders of the +85 enhancer in leukaemic cells along with previously unknown binders, including ETV6 and IKZF1. We confirmed that ETV6 and IKZF1 were also bound at the +85 enhancer in both leukaemic cells and in healthy human CD34+ haematopoietic stem and progenitor cells. Knockdown experiments confirmed that ETV6 and IKZF1 are transcriptional regulators not just of ERG, but also of a number of genes regulated by a densely interconnected network of seven transcription factors. At last, we show that ETV6 and IKZF1 expression levels are positively correlated with expression of a number of heptad genes in AML and high expression of all nine genes confers poorer overall prognosis.
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