| 1. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 2. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
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| 4. |
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| 5. |
- Kalaria, Raj, et al.
(författare)
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The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact.
- 2024
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Ingår i: Alzheimer's & dementia : the journal of the Alzheimer's Association. - 1552-5279.
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Tidskriftsartikel (refereegranskat)abstract
- Two of every three persons living with dementia reside in low- and middle-income countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of global dementia care costs occur in high-income countries (HICs), with dementia research predominantly focusing on HICs. This imbalance necessitates LMIC-focused research to ensure that characterization of dementia accurately reflects the involvement and specificities of diverse populations. Development of effective preventive, diagnostic, and therapeutic approaches for dementia in LMICs requires targeted, personalized, and harmonized efforts. Our article represents timely discussions at the 2022 Symposium on Dementia and Brain Aging in LMICs that identified the foremost opportunities to advance dementia research, differential diagnosis, use of neuropsychometric tools, awareness, and treatment options. We highlight key topics discussed at the meeting and provide future recommendations to foster a more equitable landscape for dementia prevention, diagnosis, care, policy, and management in LMICs. HIGHLIGHTS: Two-thirds of persons with dementia live in LMICs, yet research and costs are skewed toward HICs. LMICs expect dementia prevalence to more than double, accompanied by socioeconomic disparities. The 2022 Symposium on Dementia in LMICs addressed advances in research, diagnosis, prevention, and policy. The Nairobi Declaration urges global action to enhance dementia outcomes in LMICs.
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| 6. |
- Nagaraja, Ch., et al.
(författare)
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Opening remarks
- 2016
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Konferensbidrag (refereegranskat)
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| 7. |
- Sultan, Sahar, 1987-, et al.
(författare)
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The Design of 3D-Printed Polylactic Acid–Bioglass Composite Scaffold : A Potential Implant Material for Bone Tissue Engineering
- 2022
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Ingår i: Molecules. - : MDPI AG. - 1431-5157 .- 1420-3049. ; 27:21
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Tidskriftsartikel (refereegranskat)abstract
- Bio-based and patient-specific three-dimensional (3D) scaffolds can present next generation strategies for bone tissue engineering (BTE) to treat critical bone size defects. In the present study, a composite filament of poly lactic acid (PLA) and 45S5 bioglass (BG) were used to 3D print scaffolds intended for bone tissue regeneration. The thermally induced phase separation (TIPS) technique was used to produce composite spheres that were extruded into a continuous filament to 3D print a variety of composite scaffolds. These scaffolds were analyzed for their macro- and microstructures, mechanical properties, in vitro cytotoxicity and in vivo biocompatibility. The results show that the BG particles were homogeneously distributed within the PLA matrix and contributed to an 80% increase in the mechanical strength of the scaffolds. The in vitro cytotoxicity analysis of PLA-BG scaffolds using L929 mouse fibroblast cells confirmed their biocompatibility. During the in vivo studies, the population of the cells showed an elevated level of macrophages and active fibroblasts that are involved in collagen extracellular matrix synthesis. This study demonstrates successful processing of PLA-BG 3D-printed composite scaffolds and their potential as an implant material with a tunable pore structure and mechanical properties for regenerative bone tissue engineering.
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| 8. |
- Thomas, N. G., et al.
(författare)
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Fish scale derived hydroxyapatite incorporated 3D printed PLA scaffold for bone tissue engineering
- 2024
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Ingår i: New Journal of Chemistry. - 1144-0546 .- 1369-9261. ; 48:24, s. 10841-10851
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Tidskriftsartikel (refereegranskat)abstract
- Bone defect repair, particularly in the alveolar region, remains a significant hurdle in periodontics. In recent years, the spotlight in regenerative medicine has fallen on 3D-printed bone scaffolds, especially those constructed of polylactic acid (PLA) infused with hydroxyapatite. This research introduced a novel approach by developing a 3D-printed PLA scaffold enriched with hydroxyapatite derived from fish skin waste (FSHA). Mechanical compression tests revealed that the 3D-printed PLA-FSHA scaffolds had a compressive strength (13.4 ± 5.53 MPa) in the same ballpark as their reference PLA counterparts (20.3 ± 1.08 MPa). Scanning electron micrographs highlighted an average pore size in the scaffold (572 ± 33 μm) conducive to angiogenesis and facilitating cell migration and proliferation. In vitro, cytotoxicity was ascertained using the MTT assay on L929 fibroblast cells. Further in vitro cytocompatibility assessments through actin-DAPI staining and measurements of bone regeneration markers - alkaline phosphatase, osteocalcin and osteopontin-demonstrated that the PLA-FSHA scaffolds not only were biocompatible but also showcased performance on par with the commercial graft, osseograft. This lays the foundation for future in vivo evaluations of bone regenerative capabilities.
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