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- Armandi, Angelo, et al.
(författare)
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Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
- 2024
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Ingår i: Gut. - : BMJ PUBLISHING GROUP. - 0017-5749 .- 1468-3288.
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Tidskriftsartikel (refereegranskat)abstract
- Objective Hyperferritinaemia is associated with liver fibrosis severity in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed the role of serum ferritin in predicting long-term outcomes or death. Design We evaluated the relationship between baseline serum ferritin and longitudinal events in a multicentre cohort of 1342 patients. Four survival models considering ferritin with confounders or non-invasive scoring systems were applied with repeated five-fold cross-validation schema. Prediction performance was evaluated in terms of Harrell's C-index and its improvement by including ferritin as a covariate. Results Median follow-up time was 96 months. Liver-related events occurred in 7.7%, hepatocellular carcinoma in 1.9%, cardiovascular events in 10.9%, extrahepatic cancers in 8.3% and all-cause mortality in 5.8%. Hyperferritinaemia was associated with a 50% increased risk of liver-related events and 27% of all-cause mortality. A stepwise increase in baseline ferritin thresholds was associated with a statistical increase in C-index, ranging between 0.02 (lasso-penalised Cox regression) and 0.03 (ridge-penalised Cox regression); the risk of developing liver-related events mainly increased from threshold 215.5 mu g/L (median HR=1.71 and C-index=0.71) and the risk of overall mortality from threshold 272 mu g/L (median HR=1.49 and C-index=0.70). The inclusion of serum ferritin thresholds (215.5 mu g/L and 272 mu g/L) in predictive models increased the performance of Fibrosis-4 and Non-Alcoholic Fatty Liver Disease Fibrosis Score in the longitudinal risk assessment of liver-related events (C-indices>0.71) and overall mortality (C-indices>0.65). Conclusions This study supports the potential use of serum ferritin values for predicting the long-term prognosis of patients with MASLD.
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- Verscharen, Daniel, et al.
(författare)
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The angular-momentum flux in the solar wind observed during Solar Orbiter's first orbit
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 656
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We present the first measurements of the angular-momentum flux in the solar wind recorded by the Solar Orbiter spacecraft. Our aim is to validate these measurements to support future studies of the Sun's angular-momentum loss. Methods. We combined 60-min averages of the proton bulk moments and the magnetic field measured by the Solar Wind Analyser and the magnetometer onboard Solar Orbiter. We calculated the angular-momentum flux per solid-angle element using data from the first orbit of the mission's cruise phase in 2020. We separated the contributions from protons and from magnetic stresses to the total angular-momentum flux.Results. The angular-momentum flux varies significantly over time. The particle contribution typically dominates over the magnetic-field contribution during our measurement interval. The total angular-momentum flux shows the largest variation and is typically anti-correlated with the radial solar-wind speed. We identify a compression region, potentially associated with a co-rotating interaction region or a coronal mass ejection, which leads to a significant localised increase in the angular-momentum flux, albeit without a significant increase in the angular momentum per unit mass. We repeated our analysis using the density estimate from the Radio and Plasma Waves instrument. Using this independent method, we find a decrease in the peaks of positive angular-momentum flux, but otherwise, our results remain consistent.Conclusions. Our results largely agree with previous measurements of the solar wind's angular-momentum flux in terms of amplitude, variability, and dependence on radial solar-wind bulk speed. Our analysis highlights the potential for more detailed future studies of the solar wind's angular momentum and its other large-scale properties with data from Solar Orbiter. We emphasise the need for studying the radial evolution and latitudinal dependence of the angular-momentum flux in combination with data from Parker Solar Probe and other assets at heliocentric distances of 1 au and beyond.
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