| 1. |
- Burisch, J., et al.
(författare)
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Health care and patients' education in a European inflammatory bowel disease inception cohort : an ECCO-EpiCom study
- 2014
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Ingår i: Journal of Crohn's & Colitis. - : Oxford University Press (OUP). - 1873-9946 .- 1876-4479. ; 8:8, s. 811-818
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Tidskriftsartikel (refereegranskat)abstract
- Background and Aims: The EpiCom study and inception cohort was initiated in 2010 in 31 centers from 14 Western and 8 Eastern European countries, covering a 10.1 million person background population. Our aim was to investigate whether there is a difference between Eastern and Western Europe in health care and education of patients with inflammatory bowel disease (IBD).Methods: A quality of care (QoC) questionnaire was developed in the EpiCom group consisting of 16 questions covering 5 items: time interval between the onset of symptoms and diagnosis, information, education, empathy and access to health care providers.Results: Of 1,515 patients, 947 (217 east/730 west) answered the QoC questionnaire. Only 23% of all patients had knowledge about IBD before diagnosis. In Eastern Europe, significantly more patients searched out information about IBD themselves (77% vs. 68%, p < 0.05), the main source was the Internet (92% vs. 88% p = 0.23). In Western Europe, significantly more patients were educated by nurses (19% vs. 1%, p < 0.05), while in Eastern Europe, gastroenterologists were easier to contact (80% vs. 68%, p < 0.05).Conclusion: Health care differed significantly between Eastern and Western Europe in all items, but satisfaction rates were high in both geographic regions. Because of the low awareness and the rising incidence of IBD, general information should be the focus of patient organizations and medical societies. In Western Europe IBD nurses play a very important role in reducing the burden of patient management. (c) 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
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| 2. |
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| 3. |
- Burisch, J, et al.
(författare)
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Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study
- 2019
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Ingår i: Gut. - : BMJ. - 1468-3288 .- 0017-5749. ; 68:3, s. 423-433
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Tidskriftsartikel (refereegranskat)abstract
- The Epi-IBD cohort is a prospective population-based inception cohort of unselected patients with inflammatory bowel disease from 29 European centres covering a background population of almost 10 million people. The aim of this study was to assess the 5-year outcome and disease course of patients with Crohn’s disease (CD).DesignPatients were followed up prospectively from the time of diagnosis, including collection of their clinical data, demographics, disease activity, medical therapy, surgery, cancers and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis.ResultsIn total, 488 patients were included in the study. During follow-up, 107 (22%) patients received surgery, while 176 (36%) patients were hospitalised because of CD. A total of 49 (14%) patients diagnosed with non-stricturing, non-penetrating disease progressed to either stricturing and/or penetrating disease. These rates did not differ between patients from Western and Eastern Europe. However, significant geographic differences were noted regarding treatment: more patients in Western Europe received biological therapy (33%) and immunomodulators (66%) than did those in Eastern Europe (14% and 54%, respectively, P<0.01), while more Eastern European patients received 5-aminosalicylates (90% vs 56%, P<0.05). Treatment with immunomodulators reduced the risk of surgery (HR: 0.4, 95% CI 0.2 to 0.6) and hospitalisation (HR: 0.3, 95% CI 0.2 to 0.5).ConclusionDespite patients being treated early and frequently with immunomodulators and biological therapy in Western Europe, 5-year outcomes including surgery and phenotype progression in this cohort were comparable across Western and Eastern Europe. Differences in treatment strategies between Western and Eastern European centres did not affect the disease course. Treatment with immunomodulators reduced the risk of surgery and hospitalisation.
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| 4. |
- Hegyesi, G., et al.
(författare)
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Development of an FPGA-based data acquisition module for small animal PET
- 2004
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Ingår i: 2004 IEEE Nuclear Science Symposium Conference Record. - 0780387007 ; , s. 2957-2961
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Konferensbidrag (refereegranskat)abstract
- We report on the design of a DAQ module for a small animal PET camera developed at our institutes. During the design an important guideline was to develop a system which is built up from strictly identical DAQ modules, and which has no built-in hardware limitation on the maximum number of modules. The developed DAQ module comprises of an LSO scintillator crystal block, a position sensitive PMT, analog signal conditioning circuits, a digitizer, an FPGA for digital signal processing and a communication module through which the collected data is sent to a cluster of computers for post processing and storage. Instead of implementing hardware coincidence detection between the modules we attach a precise time-stamp to each event in our design, and the coincidence is determined by the data collecting computers during the post processing. The digital CFD algorithm implemented in the FPGA gives a time resolution of 2 to 3 ns FWHM for real detector signals.
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| 5. |
- Hegyesi, G., et al.
(författare)
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Ethernet based distributed data acquisition system for a small animal PET
- 2006
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Ingår i: IEEE Transactions on Nuclear Science. - 0018-9499 .- 1558-1578. ; 53:4, s. 2112-2117
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Tidskriftsartikel (refereegranskat)abstract
- We report on the design of a small animal PET scanner being developed at our institutes. The existing setup is the first version of the miniPET machine consisting of four detector modules. Each detector module consists of an 8 x 8 LSO scintillator crystal block, a position sensitive photomultiplier, a digitizer including a digital signal processing board and an Ethernet interface board. There is no hardware coincidence detection implemented in the system and coincidence is determined based on a time stamp attached to every event by a digital CFD algorithm. The algorithm is implemented in the digital signal processing board and generates a time stamp with a coincidence resolution of less than 2 us. The data acquisition system is based on Ethernet network and is highly scalable in size and performance.
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| 6. |
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| 7. |
- Imrek, J., et al.
(författare)
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Development of an improved detector module for miniPET-II
- 2007
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Ingår i: 2006 IEEE Nuclear Science Symposium Conference Record. - : IEEE. - 1424405610 - 9781424405619 ; , s. 3037-3040
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Konferensbidrag (refereegranskat)abstract
- We present a new detector module developed for miniPET-II, the second generation of the miniPET small animal PET scanners. The improved module features new hardware components for better performance: LySO crystal material, increased number of crystal segments, Hamamatsu H9500 PSPMT, Xilinx Virtex-4 FPGA and Gigabit Ethernet. However, the principle of operation is the same: no hardware coincidence detection is implemented, data is acquired in list mode and transfered over an Ethernet network. The resulting new module is more suitable for full ring configurations.
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| 8. |
- Kis, S. A., et al.
(författare)
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Comparison of Monte Carlo simulated and measured performance parameters of miniPET scanner
- 2007
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 571:02-jan, s. 449-452
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Tidskriftsartikel (refereegranskat)abstract
- In vivo imaging of small laboratory animals is a valuable tool in the development of new drugs. For this purpose, miniPET, an easy to scale modular small animal PET camera has been developed at our institutes. The system has four modules, which makes it possible to rotate the whole detector system around the axis of the field of view. Data collection and image reconstruction are performed using a data acquisition (DAQ) module with Ethernet communication facility and a computer cluster of commercial PCs. Performance tests were carried out to deter-mine system parameters, such as energy resolution, sensitivity and noise equivalent count rate. A modified GEANT4-based GATE Monte Carlo software package was used to simulate PET data analogous to those of the performance measurements. GATE was run on a Linux cluster of 10 processors (64 bit, Xeon with 3.0 GHz) and controlled by a SUN grid engine. The application of this special computer cluster reduced the time necessary for the simulations by an order of magnitude. The simulated energy spectra, maximum rate of true coincidences and sensitivity of the camera were in good agreement with the measured parameters.
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| 9. |
- Kis, S. A., et al.
(författare)
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Performance Characteristics of a miniPET Scanner Dedicated to Small Animal Imaging
- 2005
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Ingår i: 2005 IEEE Nuclear Science Symposium Conference Record. - 0780392213 - 9780780392212 ; , s. 1645-1648
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Konferensbidrag (refereegranskat)abstract
- An easy to scale up modular PET scanner was developed for imaging small animals. Energy resolution, spatial resolution and count rate performance were determined as system parameters. The configuration provided an average energy resolution of 19.6 % and the image resolution ranges was 1.5 to 2.3 mm in radial direction. The sensitivity of the miniPET was 1.08 cps/kBq as determined using a point source. In addition, results of rat brain scan performed with FDG are given to characterize imaging capability of the system. The displayed data document that the miniPET scanner supports good quality brain imaging of small animals.
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| 10. |
- Sanchez-Crespo, A., et al.
(författare)
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Proton therapy beam dosimetry with silicon CMOS image sensors
- 2004
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 525:02-jan, s. 289-293
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Tidskriftsartikel (refereegranskat)abstract
- A 16 mm(2) CMOS Image Sensor with more than 100 000 pixels and with a standard video output was irradiated with 48, 95 and 180 MeV protons. Proton-induced nuclear reactions in silicon were detected as bright spots or tracks in the images. The angular and energy-dependent response of the detector were studied. The application to proton dosimetry is discussed.
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