4. |
- Simmen, K. A., et al.
(författare)
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Macrocylic inhibitors of hepatitis C virus
- 2012
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Patent (populärvet., debatt m.m.)abstract
- Inhibitors of HCV replication of formula (I)and the N-oxides, salts, and stereoisomers, whereineach dashed line represents an optional double bond;X is N, CH and where X bears a double bond it is C;R1 is —OR7, —NH—SO2R8;R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl;R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl;R4 is aryl or Het; n is 3, 4, 5, or 6;R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het;R6 is C1-6alkoxy, or dimethylamino;R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het;R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het;aryl is phenyl optionally substituted with one, two or three substituents;Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents;pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
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5. |
- Koyi, Hemin, et al.
(författare)
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The effect of décollement dip on geometry and kinematics of model accretionary wedges.
- 2003
-
Ingår i: Journal of Structural Geology. - 0191-8141 .- 1873-1201. ; 25:9, s. 1445-1450
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Tidskriftsartikel (refereegranskat)abstract
- We conducted a series of sand-box models shortened asymmetrically above a frictional-plastic de´collement to study the influence ofamount and sense of the de´collement dip on the geometry and kinematics of accretionary wedges. Model results illustrate that the amount anddirection of de´collement dip strongly influence the geometry and mode of deformation of the resulting wedge. In general, for models havingsimilar de´collement frictional parameters, the resulting wedge is steeper, grows higher and is shorter when shortened above a de´collementthat dips toward the hinterland. At 42% bulk shortening, the length/height ratio of wedges formed above a 58-dipping de´collement was equalto 2.4 whereas this ratio was equal to 3 for wedges shortened above a horizontal de´collement. Moreover, models with a hinterland dippingde´collement undergo larger amounts of layer parallel compaction (LPC) and area loss than models shortened above a non-dippingde´collement. The effect of de´collement dip on wedge deformation is most pronounced when basal friction is relatively high (mb ¼ 0.55),whereas its effect is less significant in models where the basal de´collement has a lower friction (mb ¼ 0.37). Model results also show thatincreasing basal slope has a similar effect to that of increasing basal friction; the wedge grows taller and its critical taper steepens.
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