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- Boulo, S., et al.
(författare)
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First amyloid β1-42 certified reference material for re-calibrating commercial immunoassays
- 2020
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Ingår i: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 16:11, s. 1493-1503
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Reference materials based on human cerebrospinal fluid were certified for the mass concentration of amyloid beta (Aβ)1-42 (Aβ42). They are intended to be used to calibrate diagnostic assays for Aβ42. Methods: The three certified reference materials (CRMs), ERM-DA480/IFCC, ERM-DA481/IFCC and ERM-DA482/IFCC, were prepared at three concentration levels and characterized using isotope dilution mass spectrometry methods. Roche, EUROIMMUN, and Fujirebio used the three CRMs to re-calibrate their immunoassays. Results: The certified Aβ42 mass concentrations in ERM-DA480/IFCC, ERM-DA481/IFCC, and ERM-DA482/IFCC are 0.45, 0.72, and 1.22μg/L, respectively, with expanded uncertainties (k=2) of 0.07, 0.11, and 0.18μg/L, respectively. Before re-calibration, a good correlation (Pearson's r>0.97), yet large biases, were observed between results from different commercial assays. After re-calibration the between-assay bias was reduced to<5%. Discussion: The Aβ42 CRMs can ensure the equivalence of results between methods and across platforms for the measurement of Aβ42. © 2020 the Alzheimer's Association
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| 5. |
- Marion, G. H., et al.
(författare)
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Early Observations and Analysis of the Type Ia SN 2014J in M82
- 2015
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 798:1, s. 39-
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Tidskriftsartikel (refereegranskat)abstract
- We present optical and near infrared (NIR) observations of the nearby Type Ia SN 2014J. Seventeen optical and 23 NIR spectra were obtained from 10 days before (–10d) to 10 days after (+10d) the time of maximum B-band brightness. The relative strengths of absorption features and their patterns of development can be compared at one day intervals throughout most of this period. Carbon is not detected in the optical spectra, but we identify C I λ1.0693 in the NIR spectra. Mg II lines with high oscillator strengths have higher initial velocities than other Mg II lines. We show that the velocity differences can be explained by differences in optical depths due to oscillator strengths. The spectra of SN 2014J show that it is a normal SN Ia, but many parameters are near the boundaries between normal and high-velocity subclasses. The velocities for O I, Mg II, Si II, S II, Ca II, and Fe II suggest that SN 2014J has a layered structure with little or no mixing. That result is consistent with the delayed detonation explosion models. We also report photometric observations, obtained from –10d to +29d, in the UBVRIJH and Ksbands. The template fitting package SNooPy is used to interpret the light curves and to derive photometric parameters. UsingRV = 1.46, which is consistent with previous studies, SNooPy finds that AV = 1.80 for E(B – V)host = 1.23 ± 0.06 mag. The maximum B-band brightness of –19.19 ± 0.10 mag was reached on February 1.74 UT ± 0.13 days and the supernova has a decline parameter, Δm 15, of 1.12 ± 0.02 mag.
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| 6. |
- Venkataraman, Varun, et al.
(författare)
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Modelling Considerations for Resistance Wire Thermometers Applied to Internal Combustion Engines
- 2021
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Ingår i: SMSI 2021 - Sensors and Instrumentation. - : AMA Service GmbH. ; , s. 201-202
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Konferensbidrag (refereegranskat)abstract
- This study delves into the modelling of resistance wire thermometers (RWTs) within the applicationcontext of measuring the exhaust gas temperature pulse in internal combustion engines. The modelwas developed in a commercial simulation software utilizing the heat balance equation. Disparitieswere found between different model representations of the prongs due to differences in the heat transfer within the sensor, which impacts its expected dynamic response. The appropriate modelling choicewill be made upon validation with shock tube experiments for different RWT designs
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| 7. |
- Venkataraman, Varun, et al.
(författare)
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Resistance Wire Thermometers for Temperature Pulse Measurements on Internal Combustion Engines
- 2020
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Konferensbidrag (refereegranskat)abstract
- This study revisits the design of resistance wire thermometers (RWTs) for measuring time-resolved temperature pulsations of the exhaust gas on internal combustion engines. RWTs with gold coated tungsten wires were fabricated and tested on a heavy-duty diesel engine. Experimental results indi-cate their utility in such harsh environments with the addition of a protective ceramic coating over the welded joints. The influence of the coating on sensor geometry and response will be elucidated through shock tube and gas stand experiments.
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