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- Lopes, F. L., et al.
(författare)
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Polygenic risk for anxiety influences anxiety comorbidity and suicidal behavior in bipolar disorder
- 2020
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Ingår i: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Bipolar disorder is often comorbid with anxiety, which is itself associated with poorer clinical outcomes, including suicide. A better etiologic understanding of this comorbidity could inform diagnosis and treatment. The present study aims to test whether comorbid anxiety in bipolar disorder reflects shared genetic risk factors. We also sought to assess the contribution of genetic risk for anxiety to suicide attempts in bipolar disorder. Polygenic risk scores (PRS) were calculated from published genome-wide association studies of samples of controls and cases with anxiety (n = 83,566) or bipolar disorder (n = 51,710), then scored in independent target samples (totaln = 3369) of individuals with bipolar disorder who reported or denied lifetime anxiety disorders or suicidal attempts in research interviews. Participants were recruited from clinical and nonclinical settings and genotyped for common genetic variants. The results show that polygenic risk for anxiety was associated with comorbid anxiety disorders and suicide attempts in bipolar disorder, while polygenic risk for bipolar disorder was not associated with any of these variables. Our findings point out that comorbid anxiety disorders in bipolar disorder reflect a dual burden of bipolar and anxiety-related genes; the latter may also contribute to suicide attempts. Clinical care that recognizes and addresses this dual burden may help improve outcomes in people living with comorbid bipolar and anxiety disorders.
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- Ahrer, E., et al.
(författare)
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Atmospheric characterization and tighter constraints on the orbital misalignment of WASP-94 A b with HARPS
- 2024
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Ingår i: Monthly notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 530:3, s. 2749-2759
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Tidskriftsartikel (refereegranskat)abstract
- We present high spectral resolution observations of the hot Jupiter WASP-94 A b using the HARPS instrument on ESO’s 3.6-m telescope in La Silla, Chile. We probed for Na absorption in its atmosphere as well as constrained the previously reported misaligned retrograde orbit using the Rossiter–McLaughlin effect. Additionally, we undertook a combined atmospheric retrieval analysis with previously published low-resolution data. We confirm the retrograde orbit as well as constrain the orbital misalignment with our measurement of a projected spin-orbit obliquity of λ = 123.0 ± 3.0°. We find a tentative detection of Na absorption in the atmosphere of WASP-94 A b, independent of the treatment of the Rossiter–McLaughlin effect in our analysis (3.6σ and 4.4σ). We combine our HARPS high-resolution data with low-resolution data from the literature and find that while the posterior distribution of the Na abundance results in a tighter constraint than using a single data set, the detection significance does not improve (3.2σ), which we attribute to degeneracies between the low- and high-resolution data.
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