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| 2. |
- Freedman, Ben, et al.
(författare)
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Screening for Atrial Fibrillation A Report of the AF-SCREEN International Collaboration
- 2017
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Ingår i: Circulation. - : LIPPINCOTT WILLIAMS & WILKINS. - 0009-7322 .- 1524-4539. ; 135:19, s. 1851-
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Tidskriftsartikel (refereegranskat)abstract
- Approximately 10% of ischemic strokes are associated with atrial fibrillation (AF) first diagnosed at the time of stroke. Detecting asymptomatic AF would provide an opportunity to prevent these strokes by instituting appropriate anticoagulation. The AF-SCREEN international collaboration was formed in September 2015 to promote discussion and research about AF screening as a strategy to reduce stroke and death and to provide advocacy for implementation of country-specific AF screening programs. During 2016, 60 expert members of AF-SCREEN, including physicians, nurses, allied health professionals, health economists, and patient advocates, were invited to prepare sections of a draft document. In August 2016, 51 members met in Rome to discuss the draft document and consider the key points arising from it using a Delphi process. These key points emphasize that screen-detected AF found at a single timepoint or by intermittent ECG recordings over 2 weeks is not a benign condition and, with additional stroke factors, carries sufficient risk of stroke to justify consideration of anticoagulation. With regard to the methods of mass screening, handheld ECG devices have the advantage of providing a verifiable ECG trace that guidelines require for AF diagnosis and would therefore be preferred as screening tools. Certain patient groups, such as those with recent embolic stroke of uncertain source (ESUS), require more intensive monitoring for AF. Settings for screening include various venues in both the community and the clinic, but they must be linked to a pathway for appropriate diagnosis and management for screening to be effective. It is recognized that health resources vary widely between countries and health systems, so the setting for AF screening should be both country-and health system-specific. Based on current knowledge, this white paper provides a strong case for AF screening now while recognizing that large randomized outcomes studies would be helpful to strengthen the evidence base.
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| 3. |
- Kotecha, Dipak, et al.
(författare)
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Integrating new approaches to atrial fibrillation management : the 6th AFNET/EHRA Consensus Conference.
- 2018
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Ingår i: Europace. - : Oxford University Press (OUP). - 1099-5129 .- 1532-2092. ; 20:3, s. 395-407
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Tidskriftsartikel (refereegranskat)abstract
- There are major challenges ahead for clinicians treating patients with atrial fibrillation (AF). The population with AF is expected to expand considerably and yet, apart from anticoagulation, therapies used in AF have not been shown to consistently impact on mortality or reduce adverse cardiovascular events. New approaches to AF management, including the use of novel technologies and structured, integrated care, have the potential to enhance clinical phenotyping or result in better treatment selection and stratified therapy. Here, we report the outcomes of the 6th Consensus Conference of the Atrial Fibrillation Network (AFNET) and the European Heart Rhythm Association (EHRA), held at the European Society of Cardiology Heart House in Sophia Antipolis, France, 17-19 January 2017. Sixty-two global specialists in AF and 13 industry partners met to develop innovative solutions based on new approaches to screening and diagnosis, enhancing integration of AF care, developing clinical pathways for treating complex patients, improving stroke prevention strategies, and better patient selection for heart rate and rhythm control. Ultimately, these approaches can lead to better outcomes for patients with AF.
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| 4. |
- Kumar, Manish, et al.
(författare)
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Global co-occurrences of multi-(emerging)-contaminants in the hotspots of arsenic polluted groundwater : A pattern of menace
- 2023
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Ingår i: Current Opinion in Environmental Science & Health. - : Elsevier BV. - 2468-5844. ; 34
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Forskningsöversikt (refereegranskat)abstract
- Advancements in analytical techniques have resulted in much progress in understanding co-occurrence of environmental con-taminants. We focused on investigating the global pattern of arsenic (As) co-occurrence with inorganic and emerging con-taminants and then explained the governing factors driving the situation. Major co-occurring inorganic contaminants were found in three sets: i) U, F, Fe, Mn, Pb, & Zn; ii) Al, Mo, Cd, Sb, Br, I, and Se; and iii) Ag, Au, Cr, Cu, Hg, Th, V, Ga, and Ba. Co-occurrences were majorly governed by weathering, redox conditions, recharge/pumping, and surface leaching. Several places around the world started to exhibit As presence with contaminants of emerging concerns like pesticides, per-and polyfluoroalkyl sub-stances (PFAS), endocrine disrupting chemicals (EDCs), and others, that needs to be explored further at fundamentally deeper levels. This is probably one of the first attempts to correlate As co -occurrences with contaminants of emerging concern.
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| 6. |
- Sharma, Atul, et al.
(författare)
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Intracellular Locations of Replication Proteins and the Origin of Replication during Chromosome Duplication in the Slowly Growing Human Pathogen Helicobacter pylori
- 2014
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Ingår i: Journal of Bacteriology. - 0021-9193 .- 1098-5530. ; 196:5, s. 999-1011
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Tidskriftsartikel (refereegranskat)abstract
- We followed the position of the replication complex in the pathogenic bacterium Helicobacter pylori using antibodies raised against the single-stranded DNA binding protein (HpSSB) and the replicative helicase (HpDnaB). The position of the replication origin, oriC, was also localized in growing cells by fluorescence in situ hybridization (FISH) with fluorescence-labeled DNA sequences adjacent to the origin. The replisome assembled at oriC near one of the cell poles, and the two forks moved together toward the cell center as replication progressed in the growing cell. Termination and resolution of the forks occurred near midcell, on one side of the septal membrane. The duplicated copies of oriC did not separate until late in elongation, when the daughter chromosomes segregated into bilobed nucleoids, suggesting sister chromatid cohesion at or near the oriC region. Components of the replication machinery, viz., HpDnaB and HpDnaG (DNA primase), were found associated with the cell membrane. A model for the assembly and location of the H. pylori replication machinery during chromosomal duplication is presented.
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| 7. |
- Thakur, Hemant, et al.
(författare)
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Anaerobic co-digestion of food waste, bio-flocculated sewage sludge, and cow dung in CSTR using E(C2)Tx synthetic consortia
- 2023
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Ingår i: Environmental Technology & Innovation. - 2352-1864. ; 32
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Tidskriftsartikel (refereegranskat)abstract
- In the current study, a E(C2)Tx synthetic consortia was tested for anaerobic co-digestion of food waste (FW), bio-flocculated sewage sludge (BFS)/ raw wastewater (RW) and cow dung (CD) at varying proportions in 0.25 L and 6.5 L mesophilic continuously stirred tank reactors. Anaerobic co-digestion of FW with CD and RW at the ratio of 1:1:8 in 0.25 L batch-reactor with E(C2)Tx inoculum resulted in the highest H2 production with least CO2 release. The microbial dynamics of FW:CD:RW samples were studied using 16S metagenomic sequencing which indicated a predominance of hydrolysing microbes at the end point of the digestion cycle. Subsequently, the experiments were scaled up in two continuous digesters, namely, R1 (fed with 50% FW and 50% BFS) and R2 (fed with 2% FW and 98% BFS) with 6.5 L working volume at 2.5 g VS L-1D-1 organic loading rate (OLR) for 120 days. The highest VFA production of 19,183 mg L-1 and 3,265 mg L-1 with maximum bio-methane yield of 142.21-and 225.03-mL CH4g-1 VSadded were recorded in reactors R1 and R2, respectively. In addition, a numerical analysis was conducted to visualize the mixing and temperature distribution within the digesters, and the velocity and temperature profiles were obtained using Ansys Fluent. & COPY; 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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