| 1. |
- Jonzén, Niclas, et al.
(författare)
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Rapid advance of spring arrival dates in long-distance migratory birds
- 2006
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 312:5782, s. 1959-1961
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Tidskriftsartikel (refereegranskat)abstract
- Several bird species have advanced the timing of their spring migration in response to recent climate change. European short-distance migrants, wintering in temperate areas, have been assumed to be more affected by change in the European climate than long-distance migrants wintering in the tropics. However, we show that tong-distance migrants have advanced their spring arrival in Scandinavia more than short-distance migrants. By analyzing a long-term data set from southern Italy, we show that long-distance migrants also pass through the Mediterranean region earlier. We argue that this may reflect a climate-driven evolutionary change in the timing of spring migration.
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| 2. |
- Jonzén, Niclas, et al.
(författare)
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Response to comment on "Rapid advance of spring arrival dates in long-distance migratory birds"
- 2007
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 315:5812, s. 598-598
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Both's comment questions our suggestion that the advanced spring arrival time of long-distance migratory birds in Scandinavia and the Mediterranean may reflect a climate-driven evolutionary change. We present additional arguments to support our hypothesis but underscore the importance of additional studies involving direct tests of evolutionary change.
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| 3. |
- Knudsen, Endre, et al.
(författare)
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Characterizing bird migration phenology using data from standardized monitoring at bird observatories
- 2007
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Ingår i: Climate Research. - : Inter-Research Science Center. - 1616-1572 .- 0936-577X. ; 35:1-2, s. 59-77
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Forskningsöversikt (refereegranskat)abstract
- Long-term data from standardized monitoring programmes at bird observatories are becoming increasingly available. These data are frequently used for detecting changes in the timing of bird migration that may relate to recent climate change. We present an overview of problematic issues in the analysis of these data, and review approaches to and methods for characterizing bird migration phenology and its change over time. Methods are illustrated and briefly compared using autumn data on garden warbler Sylvia borin from a standardized mist-netting programme at Lista bird observatory, southern Norway. Bird migration phenology is usually characterized rather coarsely using a small number of sample statistics such as mean, median and selected quantiles. We present 2 alternative approaches. Smoothing methods describe the within-season pattern in the data at an arbitrary level of detail, while fitting a parametric seasonal distribution curve offers a coarse description of migration phenology relatively robust to sampling effects. Various methods for analyzing linear trends in the timing of bird migration are reviewed and discussed. Exploratory studies using long-term data gathered at bird observatories can yield more detailed insight into the phenomenon of bird migration and how phenologies relate to climate. Methodological advances are needed, particularly in order to better characterize the shape of phenological distributions and separate between sampling effects and 'true' phenology.
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| 4. |
- Sparve, Erik, et al.
(författare)
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Prediction and Modeling of Effects on the QTc Interval for Clinical Safety Margin Assessment, Based on Single-Ascending-Dose Study Data with AZD3839
- 2014
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Ingår i: Journal of Pharmacology and Experimental Therapeutics. - : American Society for Pharmacology & Experimental Therapeutics (ASPET). - 0022-3565 .- 1521-0103. ; 350:2, s. 469-478
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Tidskriftsartikel (refereegranskat)abstract
- Corrected QT interval (QTc) prolongation in humans is usually predictable based on results from preclinical findings. This study confirms the signal from preclinical cardiac repolarization models (human ether-a-go-go-related gene, guinea pig monophasic action potential, and dog telemetry) on the clinical effects on the QTc interval. A thorough QT/QTc study is generally required for bioavailable pharmaceutical compounds to determine whether or not a drug shows a QTc effect above a threshold of regulatory interest. However, as demonstrated in this AZD3839 [(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine hemifumarate] single-ascending-dose (SAD) study, high-resolution digital electrocardiogram data, in combination with adequate efficacy biomarker and pharmacokinetic data and nonlinear mixed effects modeling, can provide the basis to safely explore the margins to allow for robust modeling of clinical effect versus the electrophysiological risk marker. We also conclude that a carefully conducted SAD study may provide reliable data for effective early strategic decision making ahead of the thorough QT/QTc study.
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