| 1. |
- Björklund, Anna, et al.
(författare)
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Energiplanering med strategisk miljöbedömning i Finspång
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport är en del av slutrapporteringen från två av projekten i programmet ”Miljöstrategiska verktyg”. Projekten är Utveckling av verktyg för strategisk miljöbedömning och medborgarmedverkan (MiSt-projekt 1) samt Scenariometoder i strategisk miljöbedömning (MiSt-projekt 7). I samarbete med Finspångs kommun har ett gemensamt projekt utvecklats för att ta fram en ny energiplan i kommunen. Programmet "Miljöstrategiska verktyg", MiSt, är ett tvärvetenskapligt forskningsprogram finansierat av Naturvårdsverket. Programmet leds från Blekinge Tekniska Högskola. I programmet studeras verktyg som kan underlätta miljöbedömning i strategiskt beslutsfattande på olika nivåer, från nationell till lokal. Förståelsen och basen för utveckling av verktyg och rekommendationer om verktyg i olika planerings- och beslutsprocesser baseras på empirisk forskning på fall inom flera sektorer. Målen för MiSt-programmet: • Kritisk undersökning av verktygens funktion • Teoribaserad förståelse av deras verkan • Utveckling av råd om effektiv användning av verktyg och kombinationer avverktyg
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| 3. |
- Dyczynski, Matheus, et al.
(författare)
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Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib
- 2018
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Ingår i: Cancer Letters. - : Elsevier. - 0304-3835 .- 1872-7980. ; 435, s. 32-43
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Tidskriftsartikel (refereegranskat)abstract
- Resistance to chemotherapy is a challenging problem for treatment of cancer patients and autophagy has been shown to mediate development of resistance. In this study we systematically screened a library of 306 known anti-cancer drugs for their ability to induce autophagy using a cell-based assay. 114 of the drugs were classified as autophagy inducers; for 16 drugs, the cytotoxicity was potentiated by siRNA-mediated knock-down of Atg7 and Vps34. These drugs were further evaluated in breast cancer cell lines for autophagy induction, and two tyrosine kinase inhibitors, Sunitinib and Erlotinib, were selected for further studies. For the pharmacological inhibition of autophagy, we have characterized here a novel highly potent selective inhibitor of Vps34, SB02024. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro in monolayer cultures and when grown as multicellular spheroids. Our data suggests that inhibition of autophagy significantly improves sensitivity to Sunitinib and Erlotinib and that Vps34 is a promising therapeutic target for combination strategies in breast cancer.
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| 4. |
- Fallah, Mahsa, 1986-, et al.
(författare)
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Plasminogen is a master regulator and a potential drug candidate for the healing of radiation wounds
- 2020
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Ingår i: Cell Death and Disease. - : Nature Publishing Group. - 2041-4889. ; 11:3
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Tidskriftsartikel (refereegranskat)abstract
- Around 95% of cancer patients undergoing radiotherapy experience cutaneous side effects, and some develop radiation wounds or fibrosis. Currently, there is no effective treatment for these indications. We show here that plasminogen administration enhanced the healing of radiation wounds via pleiotropic effects on gene expression. Using RNA sequencing, we found that plasminogen downregulated the expression of genes in the TLR, TNF, WNT, MAPK, and TGF-β signaling pathways, and enhanced the anti-inflammatory effect of arachidonic acid, leading to significantly decreased inflammation and improved remodeling of granulation tissue compared with placebo treatment. In addition, plasminogen induced metabolic changes, including decreased glycolysis. Importantly, many of the factors downregulated by plasminogen are pro-fibrotic. Therefore, in radiation wounds with excessive inflammation, plasminogen is able to enhance and redirect the healing process, such that it more closely resembles physiological healing with significantly reduced risk for developing fibrosis. This makes plasminogen an attractive drug candidate for the treatment of radiation wounds in cancer patients.
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| 5. |
- Johansson, Nina, et al.
(författare)
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Ameliorating Child poverty through Connecting Economic Services with child health Services (ACCESS) : study protocol for a randomised controlled trial of the healthier wealthier families model in Sweden
- 2022
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Ingår i: BMC Public Health. - : BioMed Central (BMC). - 1471-2458. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundSweden is often held up as an example of a country with low child deprivation; yet, rates of relative deprivation are rising. Every municipality in Sweden is required to provide free, timely and accessible budget and debt counselling under the Social Services Act. The services have been encouraged to perform preventative practice with families; however, this has not been realised. The Healthier Wealthier Families (HWF) model embeds universal screening for economic hardship into child health services and creates a referral pathway to economic support services. Given the universal child health system in Sweden, which is freely available and has excellent coverage of the child population, implementation of the HWF model has potential to support families to access the freely available municipal budget and debt counselling and ultimately improve rates of child deprivation in Sweden.Methods/designWe will conduct a two-arm randomised waitlist-control superiority trial to examine the effectiveness and cost-effectiveness of the HWF model in the Sweden. A longitudinal follow-up with the cohort will explore whether any effects are maintained in the longer-term.DiscussionHWF is a collaborative and sustainable model that could maximise the effectiveness of current services to address child deprivation in Sweden. The study outlined in this protocol is the first effectiveness evaluation of the HWF model in Sweden and is a crucial step before HWF can be recommended for national implementation within the child health services.
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| 6. |
- Stenlund Nilsson Ivner, Jenny, 1976-, et al.
(författare)
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New Tools in Local Energy Planning: Experimenting with Scenarios, Public Participation and Environmental Assessment
- 2010
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Ingår i: Local Environment. - : Informa UK Limited. - 1354-9839 .- 1469-6711. ; 15:2, s. 105-120
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Tidskriftsartikel (refereegranskat)abstract
- This article presents a model for local energy planning and its application in a full-scale experiment in a Swedish municipality. The model is based on legal requirement,research findings and standards of good practice and includes a combination ofanalytical and procedural tools intended to support rational decision-making: external scenarios, a citizens’ panel, life cycle analysis and qualitative environmental assessment (EA). The application of the model indicates that the decision-support tools selected can give several new and valuable inputs to local energy planning, suchas local knowledge and values through citizen dialogue and comprehensive EAs.However, the experiment also shows that there are several challenges involved in applying the tools, for example, it is difficult to get citizens and the industry to participate and that it is complicated to combine several different tools for decision making into a single planning process. Moreover, the experiences from the application suggest that the model for local energy planning show great potential but needs to be improved before it can be used as a standard of good practice.
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