| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Ruthes, Andrea C., et al.
(författare)
-
Comparative Recalcitrance and Extractability of Cell Wall Polysaccharides from Cereal (Wheat, Rye, and Barley) Brans Using Subcritical Water
- 2020
-
Ingår i: ACS Sustainable Chemistry and Engineering. - : American Chemical Society (ACS). - 2168-0485. ; 8:18, s. 7192-7204
-
Tidskriftsartikel (refereegranskat)abstract
- Cereal brans constitute an unexploited source of valuable cell wall polysaccharides and phenolics. Sequential subcritical water extraction (SWE) of wheat, barley, and rye bran enables the isolation of cell wall polysaccharides with targeted molecular structures. The extracts switched from glucan-rich to higher contents of feruloylated arabinoxylan (F-AX) with extraction time, resulting in significant radical scavenging activity. Structurally, wheat and rye F-AXs exhibited mostly single C(O)-3 arabinose substitutions, whereas barley bran F-AX showed a complex substitution pattern. The recalcitrance of the insoluble residues after SWE was revealed by the enrichment of F-AX populations with disubstituted arabinose units and the presence of hydroxycinnamic acids, lignin, and proteins. This study demonstrates the versatility of SWE to extract cell wall polysaccharides from cereal brans with tailored molecular structures and radical scavenging activity for potential use in food and biomedical applications.
|
|
| 5. |
- van Doorn, Ljcv, et al.
(författare)
-
Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes
- 2017
-
Ingår i: Journal of Alzheimers Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 56:2, s. 543-555
-
Tidskriftsartikel (refereegranskat)abstract
- Cerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., A beta(42), total tau (t-tau), and phosphorylated tau (p-tau), is affected by differences in lateral ventricular volume (VV), using CSF biomarker data and magnetic resonance imaging (MRI) scans of 730 subjects, from 13 European Memory Clinics. We developed a Matlab-algorithm for standardized automated segmentation analysis of T1 weighted MRI scans in SPM8 for determining VV, and computed its ratio with total intracranial volume (TIV) as proxy for total CSF volume. The diagnostic power of CSF biomarkers (and their combination), either corrected for VV/TIV ratio or not, was determined by ROC analysis. CSF A beta(42) levels inversely correlated to VV/TIV in the whole study population (A beta(42): r = -0.28; p < 0.0001). For CSF t-tau and p-tau, this association only reached statistical significance in the combined MCI and AD group (t-tau: r = -0.15; p-tau: r = -0.13; both p < 0.01). Correction for differences in VV/TIV improved the differentiation of AD versus controls based on CSF A beta(42) alone (AUC: 0.75 versus 0.81) or in combination with t-tau (AUC: 0.81 versus 0.91). In conclusion, differences in VV may be an important confounder in interpreting CSF A beta(42) levels.
|
|
| 6. |
|
|
| 7. |
- Zumla, A, et al.
(författare)
-
Towards host-directed therapies for tuberculosis
- 2015
-
Ingår i: Nature reviews. Drug discovery. - : Springer Science and Business Media LLC. - 1474-1784 .- 1474-1776. ; 14:8, s. 511-
-
Tidskriftsartikel (refereegranskat)
|
|
| 8. |
- Cumplido-Mayoral, I., et al.
(författare)
-
Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer's disease and neurodegeneration stratified by sex
- 2023
-
Ingår i: Elife. - 2050-084X. ; 12
-
Tidskriftsartikel (refereegranskat)abstract
- Brain--age can be inferred from structural neuroimaging and compared to chronological age (brain--age delta) as a marker of biological brain aging. Accelerated aging has been found in neurodegenerative disorders like Alzheimer's disease (AD), but its validation against markers of neurodegeneration and AD is lacking. Here, imaging--derived measures from the UK Biobank dataset (N=22,661) were used to predict brain--age in 2,314 cognitively unimpaired (CU) individuals at higher risk of AD and mild cognitive impaired (MCI) patients from four independent cohorts with available biomarker data: ALFA+, ADNI, EPAD, and OASIS. Brain-age delta was associated with abnormal amyloid-ss, more advanced stages (AT) of AD pathology and APOE-e4 status. Brain--age delta was positively associated with plasma neurofilament light, a marker of neurodegeneration, and sex differences in the brain effects of this marker were found. These results validate brain--age delta as a non-invasive marker of biological brain aging in non--demented individuals with abnormal levels of biomarkers of AD and axonal injury.
|
|
| 9. |
|
|
| 10. |
- Rudjito, Reskandi C., et al.
(författare)
-
Feruloylated Arabinoxylans from Wheat Bran : Optimization of Extraction Process and Validation at Pilot Scale
- 2019
-
Ingår i: ACS Sustainable Chemistry and Engineering. - : American Chemical Society (ACS). - 2168-0485. ; 7:15, s. 13167-13177
-
Tidskriftsartikel (refereegranskat)abstract
- The extraction of feruloylated arabinoxylan (AX) from wheat bran was optimized in terms of the pretreatments prior to subcritical water extraction and then validated at the pilot scale. Destarching of wheat bran was critical to improve the yields and purity of the extracted AX. Time evolution profiles from sequential extractions revealed differences in the extractability of different polysaccharides, whereby beta-D-glucans were first extracted followed by AX. At longer extraction times, the AX population was more substituted and more uniform in terms of molar mass distribution. Validation of the process at pilot scale (with a scaling factor of 33) resulted in AXs with similar molecular characteristics as in the laboratory scale. Both solid to liquid ratio and extraction time were essential in improving the yields. Our study demonstrated scalability of the process, opening opportunities for the further development of multifunctional food and material products from the extracted AXs.
|
|
