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1.	Moore, K, et al. (author) A modified Camel and Cactus Test detects presymptomatic semantic impairment in genetic frontotemporal dementia within the GENFI cohort 2022 In: Applied neuropsychology. Adult. - : Informa UK Limited. - 2327-9109 .- 2327-9095. ; 29:1, s. 112-119 Journal article (peer-reviewed)
2.	Sudre, CH, et al. (author) White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study 2019 In: NeuroImage. Clinical. - : Elsevier BV. - 2213-1582. ; 24, s. 102077- Journal article (peer-reviewed)
3.	Iriondo, A., et al. (author) Cerebrospinal Fluid 7-Ketocholesterol Level is Associated with Amyloid-beta(42) and White Matter Microstructure in Cognitively Healthy Adults 2020 In: Journal of Alzheimers Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 76:2, s. 643-656 Journal article (peer-reviewed)abstract Background: Abnormal cholesterol metabolism changes the neuronal membrane and may promote amyloidogenesis. Oxysterols in cerebrospinal fluid (CSF) are related to Alzheimer's disease (AD) biomarkers in mild cognitive impairment and dementia. Cholesterol turnover is important for axonal and white matter (WM) microstructure maintenance. Objective: We aim to demonstrate that the association of oxysterols, AD biomarkers, and WM microstructure occurs early in asymptomatic individuals. Methods: We studied the association of inter-individual variability of CSF 24-hydroxycholesterol (24-OHC), 27-hydroxycholesterol (27-OHC), 7-ketocholesterol (7-KC), 7 beta-hydroxycholesterol (7 beta-OHC), amyloid-beta(42) (A beta(42)), total-tau (t-tau), phosphorylated-tau (p-tau), neurofilament (NfL), and WM microstructure using diffusion tensor imaging, generalized linear models and moderation/mediation analyses in 153 healthy adults. Results: Higher 7-KC levels were related to lower A beta(42), indicative of greater AD pathology (p = 0.041). Higher 7-KC levels were related to lower fractional anisotropy (FA) and higher mean (MD), axial (AxD), and radial (RD) diffusivity. 7-KC modulated the association between AxD and NfL in the corpus callosum splenium (B = 39.39, p = 0.017), genu (B = 68.64, p = 0.000), and fornix (B = 10.97, p = 0.000). Lower A beta(42) levels were associated to lower FA and higher MD, AxD, and RD in the fornix, corpus callosum, inferior longitudinal fasciculus, and hippocampus. The association between AxD and A beta(42) was moderated by 7K-C (p = 0.048). Conclusion: This study adds clinical evidence to support the role of 7K-C on axonal integrity and the involvement of cholesterol metabolism in the A beta(42) generation process.
4.	Ecay-Torres, M, et al. (author) Increased CAIDE dementia risk, cognition, CSF biomarkers, and vascular burden in healthy adults 2018 In: Neurology. - 1526-632X. ; 91:3, s. E217-E226 Journal article (peer-reviewed)

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Type of publication: journal article (4)

Type of content: peer-reviewed (4)

Author/Editor: Heller, C. (2); Vandenberghe, R (2); Padovani, A (2); Bargallo, N (2); Andersson, C (2); Mitchell, S (2); show more...; Levin, J (2); Freedman, M (2); Giaccone, G (2); Tagliavini, F (2); Santiago, B. (2); Graff, C (2); Jelic, V (2); Butler, C. (2); Rossi, G (2); Masellis, M (2); Gauthier, S (2); Otto, M. (2); Rosa-Neto, P. (2); Premi, E. (2); Gazzina, S. (2); Gasparotti, R. (2); Borroni, B. (2); Galimberti, D (2); Scarpini, E (2); Rohrer, JD (2); Rossor, MN (2); Rowe, JB (2); Archetti, S (2); Fenoglio, C (2); Ferreira, CB (2); Fox, NC (2); Mead, S (2); Moreno, F (2); Sánchez-Valle, R (2); van Swieten, J (2); Zulaica, M (2); de Mendonça, A (2); Bender, B (2); Verdelho, A (2); Greaves, C (2); Bocchetta, M (2); Ducharme, S (2); Finger, E (2); Fumagalli, G (2); Synofzik, M (2); Cash, DM (2); Tartaglia, MC (2); Tiraboschi, P (2); Santana, I (2); show less...

University: Karolinska Institutet (3); University of Gothenburg (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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