| 1. |
- Bremer, Hanna, et al.
(författare)
-
Disease patterns and incidence of immune-mediated disease in insured Swedish Nova Scotia Duck Tolling Retrievers
- 2015
-
Ingår i: Veterinary Record. - : Wiley. - 0042-4900 .- 2042-7670. ; 177
-
Tidskriftsartikel (refereegranskat)abstract
- In this study, morbidity in insured Nova Scotia Duck Tolling Retriever (NSDTR) dogs from Sweden was investigated and compared with all other breeds and other retriever breeds. In addition to describing common morbidities in NSDTRs, the hypotheses that NSDTRs are predisposed to lymphoma, immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA) were tested. Included in the study were 445,336 dogs; of which, 2890 were NSDTRs that had been covered by veterinary insurance from the Agria Insurance Company (Stockholm, Sweden) at some point during the years 1995-2006. Incidences of various health problems were calculated using the number of veterinary visits as the numerator and the exact time at risk as the denominator. Overall, morbidity was higher in NSDTRs compared with all other breeds, but similar compared with other retriever breeds. The most common causes of veterinary visits in NSDTRs were injuries, gastrointestinal disease and locomotor disorders, with NSDTRs at increased risk of these compared with all other breeds. The incidences for IMRD, SRMA and lymphoma were significantly higher in NSDTRs than in all other dog breeds and all other retriever breeds. The study describes morbidity in NSDTRs, and identifies several disorders to which the breed is predisposed.
|
|
| 2. |
- Vilson, Åsa, et al.
(författare)
-
Disease patterns in 32,486 insured German shepherd dogs in Sweden: 1995-2006
- 2013
-
Ingår i: Veterinary Record. - : Wiley. - 0042-4900 .- 2042-7670. ; 173
-
Tidskriftsartikel (refereegranskat)abstract
- The aims of this retrospective study were to describe the morbidity and mortality in German shepherd dogs (GSD) in Sweden, based on insurance data, and to test the hypothesis that GSDs are predisposed to immune-related diseases. Morbidity was defined as incidence rates and based on veterinary care events. Mortality was defined as mortality rates and based on life insurance data. The study included 445,336 dogs, 7.3 per cent GSDs, covered by both veterinary care and life insurance between 1995 and 2006 in the Swedish insurance company Agria (Agria Insurance Company, Stockholm, Sweden). For veterinary care events (morbidity) GSDs were most over-represented for immunological disease, with a relative risk (RR) of 2.7, compared with the risk in all other breeds combined. The most common disease category (morbidity) in GSDs was skin disorders with an incidence rate of 346.8 cases per 10,000 dog years at risk. The highest RR for cause of death in GSDs compared with all other breeds was for skin conditions (RR=7.8). Locomotor disorders were the most common cause of death in GSDs. The GSD is predisposed to immune-related disorders, such as allergies, circumanal fistulae and exocrine pancreatic atrophy, with significantly increased risk compared with all other breeds.
|
|
| 3. |
|
|
| 4. |
- Vilson, Åsa
(författare)
-
Immunity, microbiota & immune-related disorders in German shepherd dogs
- 2016
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In an epidemiological study based on insurance data we described a breed-specific pattern of diseases in German Shepherd dogs (GSD) and confirmed that this breed is predisposed to immune-related disorders. A prospective study was performed in order to further investigate immunological changes in the GSD using a large number of dogs, 30 bitches and their litters, from the same kennel under well controlled natural conditions. Changes in fecal and serum immunoglobulins were followed from birth to young adult age and possible relationships between these parameters in dams and their offspring were identified. We also described the composition of gut microbiome in dogs and how it changes in different life stages including pregnancy, lactation and growth. The levels of serum IgE, serum IgA and fecal IgA increased from seven weeks of age and were then stabilized at one year of age, there was no relationship in immunoglobulin concentrations between bitches and their 7 weeks old puppies. Dogs with high fecal IgA had a better vaccine response indicating a favorable systemic immune status. We found profound differences in the gut microbiome between mothers and young dogs. Litter mates had a more similar fecal microbiome compared to unrelated dogs. The 7 weeks old puppies were no more similar to the mothers than to unrelated bitches at partum. However, the fecal microbiome of the puppies were significantly more similar to their mothers than to unrelated bitches at 7 weeks postpartum. We observed a change in the relative abundance of different bacteria during lactation, and an increase of diversity from pregnancy to end of lactation. We also found that the diversity of fecal microbiome was affected by living environment but we were unable to demonstrate an effect of pre- and postnatal exposure to the chosen strain of probiotics. Our results provide information to an area within canine microbiology and immunology which is not studied before -this is the first study to describe the gut microbiome as well as immunoglobulins (and their relation to each other) in pregnant and lactating bitches and their offspring. This information is a needed foundation for further research on the relationship between the microbiome at an early age and immune function later in life and of value for the evaluation of interventions.
|
|
| 5. |
|
|
