| 1. |
- Bushby, Katharine, et al.
(författare)
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Ataluren treatment of patients with nonsense mutation dystrophinopathy.
- 2014
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Ingår i: Muscle & nerve. - : Wiley. - 1097-4598 .- 0148-639X. ; 50:4, s. 477-87
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Tidskriftsartikel (refereegranskat)abstract
- Dystrophinopathy is a rare, severe muscle disorder, and nonsense mutations are found in 13% of cases. Ataluren was developed to enable ribosomal readthrough of premature stop codons in nonsense mutation (nm) genetic disorders.
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| 2. |
- Reinhold, Ingo, 1981-, et al.
(författare)
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A hybrid approach combining 3D and conductive inkjet printing for the generation of linear ion traps for mass spectrometry applications
- 2014
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Ingår i: International Conference on Digital Printing Technologies. - : Society for Imaging Science and Technology. ; , s. 133-136, s. 133-136
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Konferensbidrag (refereegranskat)abstract
- Printed conductors have attracted strong interest in academia as well as the industry. While first applications using printed conductors on flat as well as curved surfaces are establishing in the market, extensive research still is conducted on the postprocessing technologies needed for high-volume fabrication of solution processed conductors. With regards to the potential low-cost, high-throughput manufacturing of conductors on inexpensive polymeric foils, new applications start to evolve that call for an even more elaborate investigation of the printing and post-processing steps included. This paper assesses the potential of inkjet-printed conductors for the use in low-pressure environments, such as linear ion-traps for mass spectrometry. In these environments remainders of trapped air or organic solvents affect the performance and lifetime of the getter pump systems used. Additionally, high frequency characteristics of the processed conductors are investigated as these are essential for the sensitivity of an ion trap. In this contribution we establish the framework for the application of conductive Inkjet printing on curved surfaces for sensing application in low-pressure environments. Inkjet-deposited nanoparticle inks were investigated with respect to their characteristics under vacuum conditions. The deposits on polymeric foils as well as on DLP processed three-dimensional semi-finished parts were subjected to thermal post-processing and measured with respect to their electrical characteristics as well as their outgassing behavior.
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| 3. |
- Reinhold, Ingo, et al.
(författare)
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Inkjet printing of phase-change materials with Xaar1001 printheads
- 2010
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Ingår i: NIP & Digital Fabrication Conference, 2010 International Conference on Digital Printing Technologies. - 9780892082933 ; , s. 319-322
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Konferensbidrag (refereegranskat)abstract
- Inkjet printing of phase-change or hot melt materials allows to produce etch masks by digital and additive processing, thus enabling highly efficient fabrication of printed circuit boards, solar cells etc. Previously the binary inkjet printing with drop volumes of 50 pL was demonstrated with Xaarl26 end-shooter printheads.[1] The present work describes new results on printing with XaarlOOl printheads. These printheads offer both, grayscale printing with a subdrop volume of 6 pL and excellent reliability by way of their unique'true throughflow' capability, respectively. While the advantage of grayscale printing for high-resolution patterning is obvious and straight forward, the complexity lies in the recirculating ink systems that provide the constant ink flow through the printhead channels. A narrow temperature range has to be established throughout the total ink path, which avoids hot spots that would damage the inks as well as cold spots that counteract the ink flow rate. Print results with Sunjet Crystal HEP9520, operating between 80 °C and 90 °C, clearly show good droplet formation for 7 distinct gray levels spanning a range from 5 to 37 pL with increments of 5.3 pL at a frequency of 5 kHz.
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| 4. |
- Voit, W., et al.
(författare)
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Application of inkjet technology for the deposition of magnetic nanoparticles to form micron-scale structures
- 2003
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Ingår i: IEE Proceedings - Science Measurement and Technology. - : Institution of Engineering and Technology (IET). - 1350-2344 .- 1359-7094. ; 150:5, s. 252-256
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Tidskriftsartikel (refereegranskat)abstract
- Inkjet printing technique has been applied to the production of magnetic layers and structures consisting of nanosized magnetic particles. These magnetic particles were synthesised by chemical methods and dispersed in suitable fluidic systems. The rheological parameters of the fluids were adjusted for inkjet printing. The resulting micron-scale pattern were obtained with a high reproducibility and structure control. The magnetic local structure of the patterns has been studied by using a new local 'in-plane' susceptibility measurement system as well as magnetic force microscopy. The deposited structures reveal a chain-like self-alignment of the magnetic particles. Potential applications of this fast and versatile process are the production of low- and medium-density magnetic mass storage patterns on almost any kind of substrate and for magnetic character recognition purposes. Printed patterns with minimal structure dimensions in the range of 50-100 mum are discussed. Work is in progress to decrease these dimensions by an order of magnitude by volume reduction of the deposited ink droplets.
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| 5. |
- Andersson, C, et al.
(författare)
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Preparation and incorporation of microcapsules in functional coatings for self-healing of packaging board
- 2009
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Ingår i: Packaging technology & science. - 0894-3214 .- 1099-1522. ; 22:5, s. 275-291
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Tidskriftsartikel (refereegranskat)abstract
- The replacement of flexible polyolefin barrier layers with novel, thin, functional polymer coatings in the production of paperboard packaging involves the risk of deteriorated barrier and mechanical properties during the converting process. Local defects or cracks in the protective barrier layer can arise because of the stress induced in creasing and folding operations. In this study, the incorporation of microencapsulated self-healing agents in coating formulations applied both by spot- and uniform-coating techniques was studied. The preparation process of microcapsules with a hydrophobic core surrounded by a hydrophobically modified polysaccharide membrane in aqueous suspension was developed to obtain capsules fulfilling both the criteria of small capsule size and reasonably high solids content to match the requirements set on surface treatment of paperboard for enhancement of packaging functionality. The survival of the microcapsules during application and their effectiveness as self-healing agents were investigated. The results showed a reduced tendency for deteriorated barrier properties and local termination of cracks formed upon creasing. The self-healing mechanism involves the rupture of microcapsules local to the applied stress, with subsequent release of the core material. Crack propagation is hindered by plasticization of the underlying coating layer, while the increased hydrophobicity helps to maintain the barrier properties.
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| 6. |
- Campbell, C., et al.
(författare)
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Meta-analyses of ataluren randomized controlled trials in nonsense mutation Duchenne muscular dystrophy
- 2020
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Ingår i: Journal of Comparative Effectiveness Research. - : Becaris Publishing Limited. - 2042-6305 .- 2042-6313. ; 9:14
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Tidskriftsartikel (refereegranskat)abstract
- Aim:Assess the totality of efficacy evidence for ataluren in patients with nonsense mutation Duchenne muscular dystrophy (nmDMD).Materials & methods:Data from the two completed randomized controlled trials (ClinicalTrials.gov: NCT00592553; NCT01826487) of ataluren in nmDMD were combined to examine the intent-to-treat (ITT) populations and two patient subgroups (baseline 6-min walk distance [6MWD] >= 300-<400 or <400 m). Meta-analyses examined 6MWD change from baseline to week 48.Results:Statistically significant differences in 6MWD change with ataluren versus placebo were observed across all three meta-analyses. Least-squares mean difference (95% CI): ITT (n = 342), +17.2 (0.2-34.1) m, p = 0.0473; >= 300-<400 m (n = 143), +43.9 (18.2-69.6) m, p = 0.0008; <400 m (n = 216), +27.7 (6.4-49.0) m, p = 0.0109.Conclusion:These meta-analyses support previous evidence for ataluren in slowing disease progression versus placebo in patients with nmDMD over 48 weeks. Treatment benefit was most evident in patients with a baseline 6MWD >= 300-<400 m (the ambulatory transition phase), thereby informing future trial design.
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| 7. |
- Haghighi, Mona, et al.
(författare)
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A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper demonstrates the value of using rule-based analysis methods that can identify subgroups with heterogeneous risk profiles in a population without imposing assumptions on the subgroups or method. The rules define the risk pattern of subsets of individuals by not only considering the interactions between the risk factors but also their ranges. We compared the rule-based analysis results with the results from a logistic regression model in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Both methods detected a similar suite of risk factors, but the rule-based analysis was superior at detecting multiple interactions between the risk factors that characterize the subgroups. A further investigation of the particular characteristics of each subgroup may detect the special health needs of the subgroup and lead to tailored interventions.
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| 8. |
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| 9. |
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| 10. |
- Kim, D. K., et al.
(författare)
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Synthesis and characterization of surfactant-coated superparamagnetic monodispersed iron oxide nanoparticles
- 2001
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Ingår i: Journal of Magnetism and Magnetic Materials. - 0304-8853 .- 1873-4766. ; 225:02-jan, s. 30-36
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Tidskriftsartikel (refereegranskat)abstract
- Synthesis and coating of superparamagnetic monodispersed iron oxide nanoparticles was carried out by chemical solution method. Controlled co-precipitation technique was used to prevent undesirable critical oxidation of Fe2+. The obtained Fe3O4 nanoparticles were coated with sodium oleate. Low-held AC susceptibility and SQUID measurement show superparamagnetism with a blocking temperature around 150K, and almost immeasurable remanence and coercivity.
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