| 1. |
- Abou-Hamad, E., et al.
(författare)
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Structural properties of carbon nanotubes derived from (13)C NMR
- 2011
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - College Park, Md. : American Physical Society. - 1098-0121 .- 1550-235X. ; 84:16, s. 165417-
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Tidskriftsartikel (refereegranskat)abstract
- We present a detailed experimental and theoretical study on how structural properties of carbon nanotubes can be derived from 13C NMR investigations. Magic angle spinning solid state NMR experiments have been performed on single-and multiwalled carbon nanotubes with diameters in the range from 0.7 to 100 nm and with number of walls from 1 to 90. We provide models on how diameter and the number of nanotube walls influence NMR linewidth and line position. Both models are supported by theoretical calculations. Increasing the diameter D, from the smallest investigated nanotube, which in our study corresponds to the inner nanotube of a double-walled tube to the largest studied diameter, corresponding to large multiwalled nanotubes, leads to a 23.5 ppm diamagnetic shift of the isotropic NMR line position d. We show that the isotropic line follows the relation d = 18.3/D + 102.5 ppm, where D is the diameter of the tube and NMR line position d is relative to tetramethylsilane. The relation asymptotically tends to approach the line position expected in graphene. A characteristic broadening of the line shape is observed with the increasing number of walls. This feature can be rationalized by an isotropic shift distribution originating from different diamagnetic shielding of the encapsulated nanotubes together with a heterogeneity of the samples. Based on our results, NMR is shown to be a nondestructive spectroscopic method that can be used as a complementary method to, for example, transmission electron microscopy to obtain structural information for carbon nanotubes, especially bulk samples.
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| 2. |
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| 3. |
- Rikard, S. Michaela, et al.
(författare)
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Mathematical Model Predicts that Acceleration of Diabetic Wound Healing is Dependent on Spatial Distribution of VEGF-A mRNA (AZD8601)
- 2021
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Ingår i: Cellular and Molecular Bioengineering. - : Springer. - 1865-5025 .- 1865-5033. ; 14:4, s. 321-338
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Pharmacologic approaches for promoting angiogenesis have been utilized to accelerate healing of chronic wounds in diabetic patients with varying degrees of success. We hypothesize that the distribution of proangiogenic drugs in the wound area critically impacts the rate of closure of diabetic wounds. To evaluate this hypothesis, we developed a mathematical model that predicts how spatial distribution of VEGF-A produced by delivery of a modified mRNA (AZD8601) accelerates diabetic wound healing. Methods We modified a previously published model of cutaneous wound healing based on coupled partial differential equations that describe the density of sprouting capillary tips, chemoattractant concentration, and density of blood vessels in a circular wound. Key model parameters identified by a sensitivity analysis were fit to data obtained from an in vivo wound healing study performed in the dorsum of diabetic mice, and a pharmacokinetic model was used to simulate mRNA and VEGF-A distribution following injections with AZD8601. Due to the limited availability of data regarding the spatial distribution of AZD8601 in the wound bed, we performed simulations with perturbations to the location of injections and diffusion coefficient of mRNA to understand the impact of these spatial parameters on wound healing. Results When simulating injections delivered at the wound border, the model predicted that injections delivered on day 0 were more effective in accelerating wound healing than injections delivered at later time points. When the location of the injection was varied throughout the wound space, the model predicted that healing could be accelerated by delivering injections a distance of 1-2 mm inside the wound bed when compared to injections delivered on the same day at the wound border. Perturbations to the diffusivity of mRNA predicted that restricting diffusion of mRNA delayed wound healing by creating an accumulation of VEGF-A at the wound border. Alternatively, a high mRNA diffusivity had no effect on wound healing compared to a simulation with vehicle injection due to the rapid loss of mRNA at the wound border to surrounding tissue. Conclusions These findings highlight the critical need to consider the location of drug delivery and diffusivity of the drug, parameters not typically explored in pre-clinical experiments, when designing and testing drugs for treating diabetic wounds.
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| 4. |
- Rundlöf, M., et al.
(författare)
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Application of the JKR method to the measurement of adhesion to Langmuir-Blodgett cellulose surfaces
- 2000
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Ingår i: Journal of Colloid and Interface Science. - : Elsevier BV. - 0021-9797 .- 1095-7103. ; 230:2, s. 441-447
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Tidskriftsartikel (refereegranskat)abstract
- The JKR method has been applied for studying adhesion between poly(dimethylsiloxane) (PDMS) caps and Langmuir-Blodgett cellulose surfaces including the substrate, hydrophobized mica, and two flat mineral surfaces, bare mica and glass, The self-adhesion of PDMS caps and oxidized PDMS caps are included as a reference to compare with literature data. The results of the measurements have been compared with previous studies using the surface force apparatus and similar systems. A satisfactory agreement is obtained for simple systems showing no, or very limited, hysteresis between loading and unloading curves, In several cases, however, a large hysteresis is found between loading and unloading curves, with a larger adhesion measured from the pull-off force than from the JKR-curve determined on loading. This is, for instance, the case for PDMS against cellulose. The situation is analogous to that found in wetting studies showing a large hysteresis between advancing and receding contact angles.
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| 5. |
- Wågberg, Thomas, et al.
(författare)
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Selective synthesis of the C3v-isomer of C60H18
- 2005
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Ingår i: Organic Letters. - : American Chemical Society (ACS). - 1523-7060 .- 1523-7052. ; 7:25, s. 5557-60
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Tidskriftsartikel (refereegranskat)abstract
- C60H18 has been produced by hydrogenation of C-60 at 100 bar H-2 pressure and 673 K for 10 h. We have investigated the crude material without any purification by use of H-1 NMR, C-13 NMR, and IR spectroscopy and Fourier transform ion cyclotron resonance mass spectrometry. We show that the crude material consists of 95% of the C-3v isomer of C60H18.
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| 6. |
- Abou-Hamad, E., et al.
(författare)
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NMR strategies to study the local magnetic properties of carbon nanotubes
- 2012
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Ingår i: Physica. B, Condensed matter. - Amsterdam : Elsevier. - 0921-4526 .- 1873-2135. ; 407:4, s. 740-742
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Tidskriftsartikel (refereegranskat)abstract
- The local magnetic properties of the one dimensional inner space of the nanotubes are investigated using C-13 nuclear magnetic resonance spectroscopy of encapsulated fullerene molecules inside single walled carbon nanotubes. Isotope engineering and magnetically purified nanotubes have been advantageously used on our study to discriminate between the different diamagnetic and paramagnetic shifts of the resonances. Ring currents originating from the pi electrons circulating on the nanotube, are found to actively screen the applied magnetic field by -36.9 ppm. Defects and holes in the nanotube walls cancel this screening locally. What is interesting, that at high magnetic fields, the modifications of the NMR resonances of the molecules from free to encapsulated can be exploited to determine some structural characteristics of the surrounding nanotubes, never observed experimentally. (C) 2011 Elsevier B.V. All rights reserved.
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| 7. |
- Acciaro, Roberta, et al.
(författare)
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Investigation of the formation, structure and release characteristics of self-assembled composite films of cellulose nanofibrils and temperature responsive microgels
- 2011
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Ingår i: Soft Matter. - : Royal Society of Chemistry (RSC). - 1744-683X .- 1744-6848. ; 7:4, s. 1369-1377
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Tidskriftsartikel (refereegranskat)abstract
- The possibility of forming self-organized films using charge-stabilized dispersions of cellulose I nanofibrils and microgel beads of poly-(N-isopropylacrylamide-co-acrylic acid) copolymer is presented. The build-up behavior and the properties of the layer-by-layer (LbL)-constructed films were studied using quartz crystal microbalance with dissipation (QCM-D) and ellipsometry. The morphology of the formed films was also characterized using atomic force microscopy (AFM) imaging. The applied methods clearly demonstrated the successful LbL-assembly of the monodisperse microgels and nanofibrils. The in situ QCM-D measurements also revealed that contrary to the polyelectrolyte bound microgel particles, the nanofibrils-bound gel beads preserve their highly swollen state and do not suffer a partial collapse due to the lack of interdigitation of the oppositely charged components. To probe the accessibility of the gel beads in the formed films, the room temperature (similar to 25 degrees C) loading and release of a fluorescent dye (FITC) was also investigated. The incorporation of the cellulose nanofibrils into the multilayer resulted in an open structure that was found easily penetrable for the dye molecules even at constant room temperature, which is in sharp contrast with previously reported systems based on synthetic polyelectrolytes. The amount of dye released from the multilayer films could be fine-tuned with the number of bilayers. Finally, the thermoresponsivity of the films was also shown by triggering the burst release of the loaded dye when the film was collapsed.
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| 8. |
- Bouhrara, M., et al.
(författare)
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Electromagnetic Properties of Inner Double Walled Carbon Nanotubes Investigated by Nuclear Magnetic Resonance
- 2013
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Ingår i: Journal of Nanomaterials. - : Hindawi Publishing Corporation. - 1687-4110 .- 1687-4129. ; 2013, s. 713475-
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Tidskriftsartikel (refereegranskat)abstract
- The nuclear magnetic resonance (NMR) analytical technique was used to investigate the double walled carbon nanotubes (DWNTs) electromagnetic properties of inner walls. The local magnetic and electronic properties of inner nanotubes in DWNTs were analyzed using 25% (13) C enriched C-60 by which the effect of dipolar coupling could be minimized. The diamagnetic shielding was determined due to the ring currents on outer nanotubes in DWNTs. The NMR chemical shift anisotropy (CSA) spectra and spin-lattice relaxation studies reveal the metallic properties of the inner nanotubes with a signature of the spin-gap opening below 70 K.
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| 9. |
- Bouhrara, M., et al.
(författare)
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High-resolution (13)C nuclear magnetic resonance evidence of phase transition of Rb,Cs-intercalated single-walled nanotubes
- 2011
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Ingår i: Journal of Applied Physics. - Woodbury, N.Y. : American Institute of Physics. - 0021-8979 .- 1089-7550. ; 110:5, s. 054306-
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Tidskriftsartikel (refereegranskat)abstract
- We present 13 C high-resolution magic-angle-turning (MAT) and magic angle spinning nuclear magnetic resonance data of Cs and Rb intercalated single walled carbon nanotubes. We find two distinct phases at different intercalation levels. A simple charge transfer is applicable at low intercalation level. The new phase at high intercalation level is accompanied by a hybridization of alkali (s) orbitals with the carbon (sp2) orbitals of the single walled nanotubes, which indicate bundle surface sites is the most probable alkali site.
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| 10. |
- Carlsson, Linn, et al.
(författare)
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Modification of cellulose model surfaces by cationic polymer latexes prepared by RAFT-mediated surfactant-free emulsion polymerization
- 2014
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Ingår i: Polymer Chemistry. - : Royal Society of Chemistry. - 1759-9954 .- 1759-9962. ; 5:20, s. 6076-6086
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the successful surface modification of a model cellulose substrate by the preparation and subsequent physical adsorption of cationic polymer latexes. The first part of the work introduces novel charged polymer nanoparticles constituted of amphiphilic block copolymers based on cationic poly(N,N-dimethylaminoethyl methacrylate-co-methacrylic acid) (P(DMAEMA-co-MAA)) as the hydrophilic segment, and poly(methyl methacrylate) (PMMA) as the hydrophobic segment. First, RAFT polymerization of N,N-dimethylaminoethyl methacrylate (DMAEMA) in water was performed at pH 7, below its pKa. The simultaneous hydrolysis of DMAEMA led to the formation of a statistical copolymer incorporating mainly protonated DMAEMA units and some deprotonated methacrylic acid units at pH 7. The following step was the RAFT-mediated surfactant-free emulsion polymerization of methyl methacrylate (MMA) using P(DMAEMA-co-MAA) as a hydrophilic macromolecular RAFT agent. During the synthesis, the formed amphiphilic block copolymers self-assembled into cationic latex nanoparticles by polymerization-induced self-assembly (PISA). The nanoparticles were found to increase in size with increasing molar mass of the hydrophobic block. The cationic latexes were subsequently adsorbed to cellulose model surfaces in a quartz crystal microbalance equipment with dissipation (QCM-D). The adsorbed amount, in mg m-2, increased with increasing size of the nanoparticles. This approach allows for physical surface modification of cellulose, utilizing a water suspension of particles for which both the surface chemistry and the surface structure can be altered in a well-defined way.
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