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| 2. |
- Nordlund, Jessica, et al.
(författare)
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Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia
- 2013
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Ingår i: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X. ; 14:9, s. r105-
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND:Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have not been comprehensively determined in all subtypes of ALL on a genome-wide scale. The relationship between DNA methylation, cytogenetic background, drug resistance and relapse in ALL is poorly understood.RESULTS:We surveyed the DNA methylation levels of 435,941 CpG sites in samples from 764 children at diagnosis of ALL and from 27 children at relapse. This survey uncovered four characteristic methylation signatures. First, compared with control blood cells, the methylomes of ALL cells shared 9,406 predominantly hypermethylated CpG sites, independent of cytogenetic background. Second, each cytogenetic subtype of ALL displayed a unique set of hyper- and hypomethylated CpG sites. The CpG sites that constituted these two signatures differed in their functional genomic enrichment to regions with marks of active or repressed chromatin. Third, we identified subtype-specific differential methylation in promoter and enhancer regions that were strongly correlated with gene expression. Fourth, a set of 6,612 CpG sites was predominantly hypermethylated in ALL cells at relapse, compared with matched samples at diagnosis. Analysis of relapse-free survival identified CpG sites with subtype-specific differential methylation that divided the patients into different risk groups, depending on their methylation status.CONCLUSIONS:Our results suggest an important biological role for DNA methylation in the differences between ALL subtypes and in their clinical outcome after treatment.
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| 3. |
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Allan Rostvik den 22 mars 1990 : En hyllningsskrift
- 1990
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Innehåll:"Aktuella problem inom nordisk namnforskning" av Thorsten Andersson"Till frågan om det gamla namnet på Västerdalälven" av Erik Olof Bergfors"Emund Slema" av Eva Brylla"Dillö" av Lennart Elmevik"Bykåka. Ett gammalt arbetsgille" av Gösta Franzén"Inkongurens av typen Sverige är beredd att.. och arkivet är ansvarig..." av Lennart Hagåsen"Ösmo — ett vantolkat sockennamn. Med en avslutande notis om medeltida kronolandbor och forntida karlar" av Lars Hellberg"Tornsvala eller tornseglare? Ansatsen till ornitologisk beteckningsreform" av Lars-Gunnar Larsson"Kyndelsmässknax och Matsmässgrav" av Helge Lindberg"Fasma" av Lennart Moberg"Har vi fått en 'ny' ortnamnsvård?" av Leif Nilsson"Det västgötska sockennamnet Undenäs" av Eva Nyman "Personbinamn i ortnamnsbelysning" av Svante Strandberg"Om ordet spjäll i svenska ägonamn" av Mats Wahlberg"Några kristna konstnamn" av Anders Öberg
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| 4. |
- Andersson, Marcus, et al.
(författare)
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Interfering signals and attenuation : potential problems with communication via the power grid
- 2006
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Ingår i: Proceedings of Nordic Distribution and Asset Management Conference.
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Konferensbidrag (refereegranskat)abstract
- This paper will give a general overview of the potential problems associated with remote-meter reading via the power grid and describe some of the technologies available. A comparison will be made between the power grid as a communication channel and other, dedicated and shared, channels. Examples will be given of practical cases in which the communication channel does not function in the intended way.
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| 5. |
- Andersson, Sören, et al.
(författare)
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A Study of Adaptive Arrays for Mobile Communication Systems
- 1990
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The application of adaptive antenna techniques to increase the channel capacity in mobile radio communication is discussed. Directional sensitivity is obtained by using an antenna array at the base station, possibly both in receiving and transmitting mode. A scheme for separating several signals at the same frequency is proposed. The method is based on high-resolution direction finding following by optimal combination of the antenna outputs. Comparisons to a method based on reference signals are made. Computer simulations are carried out to test the applicability of the technique to scattering scenarios that typically arise in urban areas. The proposed scheme is found to have great potential in rejecting cochannel interference, albeit at the expense of high computational requirements.
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| 6. |
- Andersson, Sören, et al.
(författare)
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An adaptive array for mobile communication systems
- 1991
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Ingår i: IEEE Transactions on Vehicular Technology. - Toronto, Ont, Can : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9545 .- 1939-9359. ; 40:1 pt 2, s. 230-236, s. 3289-3292
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Tidskriftsartikel (refereegranskat)abstract
- The use of adaptive antenna techniques to increase the channel capacity is discussed. Directional sensitivity is obtained by using an antenna array at the base station, possibly both in receiving and transmitting modes. A scheme for separating several signals at the same frequency is proposed. The method is based on high-resolution direction-finding followed by optimal combination of the antenna outputs. Comparison with a method based on reference signals is made. Computer simulations are carried out to test the applicability of the technique to scattering scenarios that typically arise in urban areas. The proposed scheme is found to have great potential in rejecting cochannel interference, albeit at the expense of high computational requirements.
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| 7. |
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| 8. |
- Baresel, Christian, et al.
(författare)
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Läkemedelsrester och andra skadliga ämnen i avloppsreningsverk - koncentrationer, kvantifiering, beteende och reningsalternativ
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Många läkemedelsrester och andra prioriterade substanser passerar igenom dagens avloppsreningsverk (ARV) och hamnar antingen i slammet eller i recipienten, ibland i nivåer som kan påverka vattenlevande organismer. Substanser som släpps ut via avlopps-reningsverk kan också anrikas i den akvatiska näringskedjan och orsaka effekter i högre organismer såsom fiskätande fåglar eller däggdjur, inklusive människor. Studier har också visat att antibiotika som hamnar i miljön kan bidra till uppkomsten av antibiotikaresistenta gener i bakterier, vilket är ett allvarligt globalt hot mot möjligheten att bota livshotande sjukdomar. Eftersom nuvarande vattenreningstekniker har utvecklats främst för att avlägsna partikulärt material samt kväve och fosfor är de oftast inte anpassade för att rena bort mikrobiellt stabila kemiska föroreningar. Utvärderingar av effektiviteten hos olika behandlingstekniker för avlägsnande av sådana ämnen baseras vanligtvis på analyser av förekomst av ett ämne i inkommande och utgående vatten från reningsverket. Det finns dock problem med detta tillvägagångssätt eftersom vissa ämnen metaboliseras till potentiellt mer skadliga substanser, som då inte automatiskt fångas i analysen. Dessutom kan vissa ämnen spontant bildas i reningsverken, vilket kan resultera i högre nivåer i utgående än i inkommande vatten. Ett ytterligare problem är att de utgående koncentrationerna ibland kan vara lägre än detektions-gränserna, men trots det ändå vara högre än eller nära etablerade risknivåer. This report is only available in Swedish.
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| 9. |
- Baresel, Christian, et al.
(författare)
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Pharmaceutical residues and other emerging substances in the effluent of sewage treatment plants
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Pharmaceutical residues and other emerging substances pass through modern sewage treatment plants (STPs) and end up in the receiving waters and sludge. In several studies, recipient concentrations have been detected with expected effects on aquatic organisms. Chemicals released via STPs may also enter the aquatic food-web and cause effects in higher organisms such as fish-eating birds or mammals including humans. Studies have also shown that antibiotics in the environment may contribute to the increase of antibiotic resistant genes in bacteria, which is a serious threat to our possibility to cure life-threatening diseases on the global scale. Current STP treatment technologies are usually not fit to remove microbial stable chemical pollutants and the evaluation of the removal efficiency of the STP systems applied today, is not complete. The evaluation of the removal efficiency of the substances in the STP systems is usually based on chemical analysis of the presence of certain substances in influent and effluent waters. However, there are difficulties associated with this approach, e.g. since some substances are metabolized into potentially more harmful substances which are not captured in the analysis unless they are actively sought for. Furthermore, some substances are formed in the STPs, resulting in higher levels in effluents than in influents. In addition, effluent concentrations may sometimes be lower than the analytical detection limits, yet still higher than or close to established risk concentrations emphasizing the need for developments of the analytical methods.
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| 10. |
- Bollen, Math, et al.
(författare)
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A wind park emitting characteristic and non-characteristic harmonics
- 2010
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Ingår i: 2010 14th International Power Electronics and Motion Control Conference (EPE/PEMC 2010). - Piscataway, NJ : IEEE Communications Society. - 9781424478569 ; , s. S14-22-S14-26
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Konferensbidrag (refereegranskat)abstract
- This paper shows measurements of the emission of harmonics by a small windpark. The spectrum consists of the characteristic harmonics associated with six-pulse converters and a broadband spectrum covering frequencies at which emission normally is not present. These frequencies are caused by the switching pattern of the power-electronics converters. Similar spectra have been reported by other authors and for other types of modern converters. Whereas the actual emission is small, the presence of emission at non-characteristic frequencies could result in voltage distortion limits being exceeded.
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