| 1. |
- King, Carina, et al.
(författare)
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COVID-19—a very visible pandemic
- 2020
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Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 396:10248, s. 15-15
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Robins Wahlin, Tarja-Brita, et al.
(författare)
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Episodic Learning and Memory in Prodromal Huntington’s Disease : The Role of Multimodal Encoding and Selective Reminding
- 2015
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Ingår i: International Journal of Clinical Medicine. - : Scientific Research Publishing, Inc.. - 2158-284X .- 2158-2882. ; 6:11, s. 876-886
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Tidskriftsartikel (refereegranskat)abstract
- This study investigated episodic memory in prodromal HD. Three groups were compared (N=70): mutation carriers with less than 12.5 years to disease onset (n=16), mutation carriers with 12.5 or more years to disease onset (n=16), and noncarriers (n=38). Episodic memory was assessed using the Fuld Object Memory Evaluation, which includes multimodal presentation and selective reminding, and the Claeson-Dahl Learning Test which includes verbal repeated presentation and recall trials. Both carrier groups demonstrated deficient episodic memory compared to noncarriers. The results suggest deficient episodic memory in prodromal HD, and that inconsistent retrieval contributes to these deficits. Multimodal presentation attenuates the deficits.
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| 3. |
- Robins Wahlin, Tarja-Brita, et al.
(författare)
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Non-verbal and verbal fluency in prodromal Huntington’s disease
- 2015
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Ingår i: Dementia and Geriatric Cognitive Disorders Extra. - : S. Karger AG. - 1664-5464. ; 5:3, s. 517-529
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Tidskriftsartikel (refereegranskat)abstract
- Background: This study examines nonverbal (design) and verbal (phonemic and semantic) fluency in prodromal Huntington’s disease (HD). An accumulating body of research indicates subtle deficits in cognitive functioning among prodromal mutation carriers for HD. Methods: Performance was compared between 32 mutation carriers and 38 noncarriers in order to examine the magnitude of impairment across fluency tasks. The Predicted Years To Onset (PYTO) in mutation carriers was calculated by a regression equation and used to divide the group according to whether onset was predicted less than 12.75 years (HD+CLOSE; n=16) or greater than 12.75 years (HD+DISTANT; n=16). Results: The results indicate that both nonverbal and verbal fluency are sensitive to subtle impairment in prodromal HD. HD+CLOSE group produced fewer items in all assessed fluency tasks compared to noncarriers. HD+DISTANT produced fewer drawings than noncarriers in the nonverbal task. PYTO correlated significantly with all measures of nonverbal and verbal fluency. Conclusion: The pattern of results indicates that subtle cognitive deficits exist in prodromal HD, and that less structured tasks with high executive demands are the most sensitive in detecting divergence from the normal range of functioning. These selective impairments can be attributed to the early involvement of frontostriatal circuitry and frontal lobes.
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| 4. |
- Wahlin, Åke, et al.
(författare)
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Longitudinal evidence of the impact of normal thyroid stimulating hormone variations on cognitive functioning in very old age.
- 2005
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Ingår i: Psychoneuroendocrinology. - : Elsevier BV. - 0306-4530. ; 30:7, s. 625-637
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to examine longitudinal associations among thyroid stimulating hormone (TSH) levels and cognitive performance. Data collected at the first three assessment times, approximately 3 years apart, are reported for the survivors (nZ45) from a previously published cross-sectional study. Participants were aged 75–93 years at baseline, and data reported were collected in the Kungsholmen Project, a longitudinal project investigating aging and dementia. Analyses revealed that although declining verbal fluency and visuospatial abilities were accompanied by simultaneously declining TSH levels, the pattern of crosssectional and longitudinal results are interpreted such that declining TSH levels may have caused episodic memory deficits later on. These results were obtained in the examination of 6-year but not 3-year change, and after removal of the cognitive variation associated with depressive mood symptoms.
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| 5. |
- Wahlin, Åke, et al.
(författare)
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Vitamin B Status and Cognitive Performance in Preclinical and Clinical Alzheimer’s Disease : Data from the Kungsholmen Project
- 2008
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Ingår i: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 25:1, s. 23-31
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Tidskriftsartikel (refereegranskat)abstract
- Background/Aims: The impact of vitamin B status on cognitive functioning in Alzheimer’s disease (AD) is disputed. Using a population-based sample, we examined the associations of vitamin B12 and folate with cognitive functioning in clinical (n = 44) and preclinical (n = 39) AD. Methods: The groups were subdivided in terms of low (<200 pmol/l) versus normal levels of B12 and low (<13 nmol/l) versus normal folate levels. Participants were administered tests of verbal and nonverbal episodic memory, visuospatial abilities and verbal fluency. Results: As expected, the preclinical AD group performed better than the AD group across most cognitive tests. More interestingly, the effects of low vitamin B12 and folate levels were negligible across all cognitive tests in clinical and preclinical AD. Conclusion: These findings suggest that the influence of vitamin B deficiency on cognitive functioning is overshadowed by the neurodegenerative processes associated with AD.
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| 6. |
- Airaksinen, Eija, et al.
(författare)
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Cognitive and social functioning in recovery from depression: Results from a population-based three-year follow-up
- 2006
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Ingår i: Journal of Affective Disorders. - : Elsevier BV. - 0165-0327. ; 96:1-2, s. 107-110
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Tidskriftsartikel (refereegranskat)abstract
- Background: This study prospectively examined cognitive and social functioning in recovery from depression using participants sampled from the general population. Method: Seventy-six depressed persons fulfilling (n=41) and not fulfilling (n=35) the criteria for DSM-IV depression at a threeyear follow-up were compared with respect to episodic memory performance and social functioning at baseline (T1), at follow-up (T2) and change across time. Results: The groups did not differ in episodic memory performance either at T1, T2 or in residual change. However, the groups differed in social functioning at T2 and in residual change indicating improved social functioning in the recovered group. Limitation: The absence of a healthy control group at follow-up. Conclusion: Despite the symptomatic improvement and improved social functioning, cognitive functioning does not follow this general recovery trend, at least not in the three-year interval examined.
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| 7. |
- Airaksinen, Eija, et al.
(författare)
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Low episodic memory performance as a premorbid marker of depression: : Evidence from a 3-year follow-up
- 2007
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Ingår i: Acta Psychiatrica Scandinavica. ; 115:6, s. 458-465
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Objective: To examine low episodic memory scores as a potential risk factor for depression.Method: A population-based sample of non-depressed individuals (20–64 years) were re-examined 3 years after an initial screening (n ¼ 708). At baseline, information on episodic memory scores, demographic and socioeconomic factors, alcohol use and anxiety diagnoses was collected. The data for depression diagnoses were collected at both baseline and follow-up.Results: Logistic regressions, conducted on three separate study groups that were defined according to three assessments of episodic memory (i.e. free + cued recall, free recall, cued recall) among individuals who scored in the 25 lowest or highest percentiles in the memory tests, revealed that low episodic memory performance defined as the sum of free and cued recalls of organizable words constitutes a risk of depression diagnosis 3 years later.Conclusion: Low episodic memory performance predated depressive diagnosis and might be considered as a premorbid marker of depression.
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| 8. |
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| 9. |
- Broström, Anders, et al.
(författare)
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Sex-Specific Associations Between Self-reported Sleep Duration, Cardiovascular Disease, Hypertension, and Mortality in an Elderly Population
- 2018
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Ingår i: Journal of Cardiovascular Nursing. - : Lippincott Williams & Wilkins. - 0889-4655 .- 1550-5049. ; 33:5, s. 422-428
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Both short and long sleep durations have been associated to increased mortality. Knowledge about sex-specific differences among elderly regarding associations between sleep duration, cardiovascular health, and mortality is sparse.OBJECTIVE: The aims of this study are to examine the association between self-reported sleep duration and mortality and to investigate whether this association is sex specific and/or moderated by cardiovascular morbidity, and also to explore potential mediators of sleep duration effects on mortality.METHODS: A population-based, observational, cross-sectional design with 6-year follow-up with mortality as primary outcome was conducted. Self-rated sleep duration, clinical examinations, echocardiography, and blood samples (N-terminal fragment of proBNP) were collected. A total of 675 persons (50% women; mean age, 78 years) were divided into short sleepers (≤6 hours; n = 231), normal sleepers (7-8 hours; n = 338), and long sleepers (≥9 hours; n = 61). Data were subjected to principal component analyses. Cardiovascular disease (CVD) and hypertension factors were extracted and used as moderators and as mediators in the regression analyses.RESULTS: During follow-up, 55 short sleepers (24%), 68 normal sleepers (20%), and 21 long sleepers (34%) died. Mediator analyses showed that long sleep was associated with mortality in men (hazard ratio [HR], 1.8; P = .049), independently of CVD and hypertension. In men with short sleep, CVD acted as a moderator of the association with mortality (HR, 4.1; P = .025). However, when using N-terminal fragment of proBNP, this effect became nonsignificant (HR, 3.1; P = .06). In woman, a trend to moderation involving the hypertension factor and short sleep was found (HR, 4.6; P = .09).CONCLUSION: Short and long sleep duration may be seen as risk markers, particularly among older men with cardiovascular morbidity.
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| 10. |
- Broström, Anders, et al.
(författare)
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Sex-specific associations between self-reported sleep duration, depression, anxiety, fatigue and daytime sleepiness in an older community-dwelling population
- 2018
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Ingår i: Scandinavian Journal of Caring Sciences. - : John Wiley & Sons. - 0283-9318 .- 1471-6712. ; :1, s. 290-298
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The purpose of this study was to explore whether associations between self-reported sleep duration, depressive symptoms, anxiety, fatigue and daytime sleepiness differed in older community-dwelling men and women. Design: Cross-sectional.Methods: A community-dwelling sample of 675 older men and women (mean age 77.7 years, SD 3.8 years) was used. All participants underwent a clinical examination by a cardiologist. Validated questionnaires were used to investigate sleep duration, depressive symptoms, anxiety, fatigue and daytime sleepiness. Subjects were divided into short sleepers (≤6 hours), n = 231; normal sleepers (7-8 hours), n = 338; and long sleepers (≥9 hours), n = 61. ancovas were used to explore sex-specific effects.Results: Depressive symptoms were associated with short sleep in men, but not in women. Fatigue was associated with both short and long sleep duration in men. No sex-specific associations of sleep duration with daytime sleepiness or anxiety were found.Conclusion: Nurses investigating sleep duration and its correlates, or effects, in clinical practice need to take sex into account, as some associations may be sex specific. Depressive symptoms and fatigue can be used as indicators to identify older men with sleep complaints.
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