| 1. |
- Bengtsson, Hans, et al.
(författare)
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V2331 Cygni is an Algol Variable With Deep Eclipses
- 2013
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Ingår i: The Journal of the American Association of Variable Star Observers. - 2380-3606. ; 41:2, s. 264-266
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Tidskriftsartikel (refereegranskat)abstract
- We report the discovery that V2331 Cygni is not an L star but an eclipsing variable with deep minima, and present a determination of the elements of the star: Epoch = HJD 2456184.296 ±0.001 and Period = 1.3886 ± 0.0001 days.
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| 2. |
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| 3. |
- Dvorak, Dominik, et al.
(författare)
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Curriculum Making and Subject Traditions : Curriculum Reforms in Social Studies and Physics and the Concept of Knowledge
- 2019
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Ingår i: Presented at ECER 2019.
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Konferensbidrag (refereegranskat)abstract
- In Sweden, a knowledge debate was initiated in the early 1990s through the official report School for Bildung (SOU 1992:94). The purpose of the report was two-fold: to widen the concept of knowledge from a one-sided cognitive meaning and to offer ‘new’ concepts of knowledge adapted to a performance model (Bernstein 2000) of school curriculum. Since this official investigation in the early 1990s, a new grading system and a standards-based and subject-based model of curriculum with prescribed ‘knowledge requirements’, have been implemented, but the knowledge base in the first part of the curriculum has remained the same. Two overarching issues are addressed in this paper: i) The transnational influence on educational knowledge concepts and ii) the transnational influence on curriculum structure resulting in standards-based curriculum. Both aspects are explored in relation to the implications for the subject of social science (civics). Thus, we especially examine what education is for (Biesta 2011) in social science, as it is expressed within the Swedish framework of curriculum. The purpose of this paper is to analyse the Swedish ‘hybrid’ curriculum, composed of a content- and subject based idea on the one hand and an idea of a result-focused, ability-centered curriculum on the other hand, in relation to social science. In the study, the following research questions, focused on curriculum making, are explored: How is knowledge in civics expressed in the Swedish curricula for compulsory and upper secondary school? What are the implications of transnational influences of the concepts of standards and competences for the subject of civics? Theoretical framework and method In the theoretical framework, we draw on Bernstein’s (2000) two pedagogical models, as well as his understanding of horizontal and vertical knowledge in order to relate the Swedish curricula Lgr 11 (compulsory school) and Lgy 11 (upper secondary school) to a theoretical model of curriculum. Following Deng & Luke (2008), we explore the character of the knowledge concept in the school subject of civics. The dominating knowledge discourse is related to a typology of civics (Barr; Barth & Shermis 1977; Englund 1997; Wahlström 2014). We specifically discuss the assessment practice and its consequences for how the knowledge in the subject is understood (Adolfsson 2018, Vogt 2017). In the analysis, we illustrate the subject tradition of social sciences in Sweden, as representative for the Nordic countries, as well as the subject’s current dilemmas in a standards-based curriculum.
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| 4. |
- Johnsson, Jesper, et al.
(författare)
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Functional outcomes associated with varying levels of targeted temperature management after out-of-hospital cardiac arrest — An INTCAR2 registry analysis
- 2020
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Ingår i: Resuscitation. - : Elsevier BV. - 0300-9572 .- 1873-1570. ; 146, s. 229-236
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) has been recommended in international guidelines since 2005. The TTM-trial published in 2013 showed no difference in survival or neurological outcome for patients randomised to 33 °C or 36 °C, and many hospitals have changed practice. The optimal utilization of TTM is still debated. This study aimed to analyse if a difference in temperature goal was associated with outcome in an unselected international registry population. Methods: This is a retrospective observational study based on a prospective registry — the International Cardiac Arrest Registry 2. Patients were categorized as receiving TTM in the lower range at 32–34 °C (TTM-low) or at 35–37 °C (TTM-high). Primary outcome was good functional status defined as cerebral performance category (CPC) of 1–2 at hospital discharge and secondary outcome was adverse events related to TTM. A logistic regression model was created to evaluate the independent effect of temperature by correcting for clinical and demographic factors associated with outcome. Results: Of 1710 patients included, 1242 (72,6%) received TTM-low and 468 (27,4%) TTM-high. In patients receiving TTM-low, 31.3% survived with good outcome compared to 28.8% in the TTM-high group. There was no significant association between temperature and outcome (p = 0.352). In analyses adjusted for baseline differences the OR for a good outcome with TTM-low was 1.27, 95% CI (0.94–1.73). Haemodynamic instability leading to discontinuation of TTM was more common in TTM-low. Conclusions: No significant difference in functional outcome at hospital discharge was found in patients receiving lower- versus higher targeted temperature management.
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| 5. |
- Karlsson, Thomas, et al.
(författare)
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50 Forgotten Miras
- 2016
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Ingår i: Journal of the American Association of Variable Star Observers. - Cambridge. - 0271-9053 .- 2380-3606. ; 44:2, s. 156-163
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Tidskriftsartikel (refereegranskat)abstract
- We report the results of 4 years observing of 50 poorly studied Mira stars. 247 maxima and 241 minima together with current period elements, ranges, and color indices for the stars are presented. “50 forgotten Miras” is an ongoing observing program run by the Variable star section of the Association of Swedish Amateur Astronomers (SAAF/V) that started in 2012.
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| 6. |
- Lundmark, Robert, et al.
(författare)
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A joint training of healthcare line managers and health and safety representatives in facilitating occupational health interventions: a feasibility study protocol for the Co-pilot project
- 2024
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Ingår i: Frontiers in Psychology. - : Frontiers Media S.A.. - 1664-1078. ; 15
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Tidskriftsartikel (refereegranskat)abstract
- Healthcare employees are experiencing poor wellbeing at an increasing rate. The healthcare workforce is exposed to challenging tasks and a high work pace, a situation that worsened during and after the COVID-19 pandemic. In turn, exposure to these high demands contributes to poor health, increased turnover, reduced job satisfaction, reduced efficacy, and reduced patient satisfaction and safety. Therefore, it is imperative that we identify measures to mitigate this crisis. One piece of this puzzle is how to implement sustainable tools and processes to improve the work environment of healthcare organizations. In this paper, we present the study protocol for the outlining and piloting of a joint training for pairs of healthcare line managers and their associated health and safety representatives in a Swedish healthcare organization. The objective of the training is to aid and advance the implementation of interventions to improve the work environment at the unit level. Following recommendations in the literature, the training is based on a stepwise approach that considers the specific context and focuses on the involvement of employees in creating interventions based on their needs. A central component of the training is the development of the pairs’ collaboration in prioritizing, developing, implementing, and evaluating the interventions. The training is based on an on-the-job train-the-trainer approach in which participants are progressively trained during four workshops in the steps of a participatory intervention process. Between these workshops, the pairs follow the same progressive steps together with their employees to develop and implement interventions at their unit. The pilot will involve four pairs (i.e., eight participants) representing different parts and functions of the organization and will be conducted over a period of three months. We will use a mixed method design to evaluate preconditions, the process, and proximal transfer and implementation outcome factors of the training. The overall aim of the pilot is to appraise its feasibility and be able to adjust the training before a potential scale-up.
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| 7. |
- Opoku, Robert Ankomah, et al.
(författare)
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Online communication of brand personality : a study of MBA programs of top business schools
- 2009
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Ingår i: Journal of General Management. - : SAGE Publications. - 0306-3070 .- 1759-6106. ; 35:1, s. 47-64
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Tidskriftsartikel (refereegranskat)abstract
- Brand personality has often been considered from the perspective of products, corporate brands or countries, but rarely among service offerings. Moreover, there remains the consideration of how these entities are communicated online. This article explores the brand personality dimensions that business schools communicate and whether they differ in putting across clear and distinctive brand personalities in cyberspace. Three clusters from the Financial Times' top 100 full-time global MBA programs in 2005 are used to undertake a combination of computerised content and correspondence analyses. The content analysis was structured using Aaker's five-dimensional framework whilst the positioning maps were produced by examining the data using correspondence analysis. Results indicate that some schools have clear brand personalities while others fail to communicate their brand personalities in a distinct way. This study also illustrates a powerful, but simple and relatively inexpensive way for organisations and brand researchers to study the brand personalities actually being communicated.
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| 8. |
- Sjöland, Wilhelm, et al.
(författare)
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Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid composition
- 2023
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Ingår i: Clinical Science. - 0143-5221. ; 137:13, s. 995-1011
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Tidskriftsartikel (refereegranskat)abstract
- Mice with deletion of Cyp2c70 have a human-like bile acid composition, display age-and sex-dependent signs of hepatobiliary disease and can be used as a model to study interactions between bile acids and the gut microbiota in cholestatic liver disease. In the present study, we rederived Cyp2c70-/- mice as germ-free (GF) and colonized them with a human or a mouse microbiota to investigate whether the presence of a microbiota can be protective in cholangiopathic liver disease associated with Cyp2c70-deficiency. GF Cyp2c70-/- mice showed reduced neonatal survival, liver fibrosis, and distinct cholangiocyte proliferation. Colonization of germ-free breeding pairs with a human or a mouse microbiota normalized neonatal survival of the offspring, and particularly colonization with mouse microbiota from a conventionally raised mouse improved the liver phenotype at 6-10 weeks of age. The improved liver phenotype in conventionalized (CD) Cyp2c70-/- mice was associated with increased levels of tauro-ursodeoxycholic acid (TUDCA) and UDCA, resulting in a more hydrophilic bile acid profile compared with GF and humanized Cyp2c70-/- mice. The hydrophobicity index of biliary bile acids of CD Cyp2c70-/- mice was associated with changes in gut microbiota, liver weight, liver transaminases, and liver fibrosis. Hence, our results indicate that neonatal survival of Cyp2c70-/- mice seems to depend on the establishment of a gut microbiota at birth, and the improved liver phenotype in CD Cyp2c70-/- mice may be mediated by a larger proportion of TUDCA/UDCA in the circulating bile acid pool and/or by the presence of specific bacteria.
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| 9. |
- Truedson, Petra, et al.
(författare)
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Serious adverse drug events associated with psychotropic treatment of bipolar or schizoaffective disorder : a 17-year follow-up on the LiSIE retrospective cohort study
- 2024
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Ingår i: Frontiers in Psychiatry. - : Frontiers Media S.A.. - 1664-0640. ; 15
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Mood stabilisers and other psychotropic drugs can lead to serious adverse drug events (ADEs). However, the incidence remains unknown. We aimed to (a) determine the incidence of serious ADEs in patients with bipolar or schizoaffective disorders, (b) explore the role of lithium exposure, and (c) describe the aetiology.Methods: This study is part of the LiSIE (Lithium—Study into Effects and Side Effects) retrospective cohort study. Between 2001 and 2017, patients in the Swedish region of Norrbotten, with a diagnosis of bipolar or schizoaffective disorder, were screened for serious ADEs to psychotropic drugs, having resulted in critical, post-anaesthesia, or intensive care. We determined the incidence rate of serious ADEs/1,000 person-years (PY).Results: In 1,521 patients, we identified 41 serious ADEs, yielding an incidence rate of 1.9 events per 1,000 PY. The incidence rate ratio (IRR) between ADEs with lithium present and causally implicated and ADEs without lithium exposure was significant at 2.59 (95% CI 1.20–5.51; p = 0.0094). The IRR of ADEs in patients <65 and ≥65 years was significant at 3.36 (95% CI 1.63–6.63; p = 0.0007). The most common ADEs were chronic lithium intoxication, oversedation, and cardiac/blood pressure-related events.Discussion: Serious ADEs related to treatment of bipolar (BD) or schizoaffective disorder (SZD) were uncommon but not rare. Older individuals were particularly at risk. The risk was higher in individuals exposed to lithium. Serum lithium concentration should always be checked when patients present with new or unclear somatic symptoms. However, severe ADEs also occurred with other mood stabilisers and other psychotropic drugs.
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| 10. |
- Wahlström, Jan, et al.
(författare)
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Identification of HLA-DR-bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis
- 2007
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Ingår i: Journal of Clinical Investigation. - 0021-9738 .- 1558-8238. ; 117:11, s. 3576-3582
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Tidskriftsartikel (refereegranskat)abstract
- Sarcoidosis is an inflammatory disease of unknown etiology, most commonly affecting the lungs. Activated CD4(+) T cells accumulate in the lungs of individuals with sarcoidosis and are considered to be of central importance for inflammation. We have previously shown that Scandinavian sarcoidosis patients expressing the HLADR allele DRB1*0301 are characterized by large accumulations in the lungs of CD4(+) T cells expressing the TCR AV2S3 gene segment. This association afforded us a unique opportunity to identify a sarcoidosis-specific antigen recognized by AV2S3(+) T cells. To identify candidates for the postulated sarcoidosis-specific antigen, lung cells from 16 HLA-DRB1*0301(pos) patients were obtained by bronchoalveolar lavage. HLA-DR molecules were affinity purified and bound peptides acid eluted. Subsequently, peptides were separated by reversed-phase HPLC and analyzed by liquid chromatography-mass spectrometry. We identified 78 amino acid sequences from self proteins presented in the lungs of sarcoidosis patients, some of which were well-known autoantigens such as vimentin and ATP synthase. For the first time, to our knowledge, we have identified HLA-bound peptides presented in vivo during an inflammatory condition. This approach can be extended to characterize HLA-bound peptides in various autoimmune settings.
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