| 1. |
- Brütt, Katharina, et al.
(författare)
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Competition and moral behavior: A meta-analysis of forty-five crowd-sourced experimental designs
- 2023
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Ingår i: Proceedings of the National Academy of Sciences - PNAS. - : National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 120:23
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Tidskriftsartikel (refereegranskat)abstract
- Does competition affect moral behavior? This fundamental question has been debated among leading scholars for centuries, and more recently, it has been tested in experimental studies yielding a body of rather inconclusive empirical evidence. A potential source of ambivalent empirical results on the same hypothesis is design heterogeneity-variation in true effect sizes across various reasonable experimental research protocols. To provide further evidence on whether competition affects moral behavior and to examine whether the generalizability of a single experimental study is jeopardized by design heterogeneity, we invited independent research teams to contribute experimental designs to a crowd-sourced project. In a large-scale online data collection, 18,123 experimental participants were randomly allocated to 45 randomly selected experimental designs out of 95 submitted designs. We find a small adverse effect of competition on moral behavior in a meta-analysis of the pooled data. The crowd-sourced design of our study allows for a clean identification and estimation of the variation in effect sizes above and beyond what could be expected due to sampling variance. We find substantial design heterogeneity-estimated to be about 1.6 times as large as the average standard error of effect size estimates of the 45 research designs-indicating that the informativeness and generalizability of results based on a single experimental design are limited. Drawing strong conclusions about the underlying hypotheses in the presence of substantive design heterogeneity requires moving toward much larger data collections on various experimental designs testing the same hypothesis.
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| 2. |
- Galimshina, Alina, 1993, et al.
(författare)
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High-resolution and localized parametric embodied impact calculator of PV systems
- 2023
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Ingår i: IOP Conference Series: Earth and Environmental Science. - 1755-1307 .- 1755-1315. ; 1196:1
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Konferensbidrag (refereegranskat)abstract
- Buildings are responsible for a large amount of greenhouse gas emissions in the world. In order to decarbonize the electricity grid and reduce the environmental impact of the building stock, photovoltaic panels can be installed. However, in order to assess the environmental impact of PVs, the whole life cycle has to be considered including embodied emissions. Several options for photovoltaics exist on the market or are under development including silicon-based panels, thin films, and third generation panels. Currently, many configurations of the panels exist making it difficult to estimate the embodied impact. The goal of this paper is to close this gap by providing a parametric PV carbon calculator for designers and decision-makers. In this study, the embodied impact of different PV types and configurations is assessed. First, the life cycle inventories data and bill of quantities for different generations' panel types are gathered. Second, life cycle impact assessment is performed. The results of the analysis are presented in a form of a software application allowing users to select the panel's composition, e.g., frame and glass type, cell type, encapsulant, etc. The developed application will assist in understanding the impact of choices made in regards to PV systems and will support engineers and architects in the selection of the photovoltaic panels from embodied impact perspective.
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| 3. |
- Gispert, Suzana, et al.
(författare)
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The modulation of Amyotrophic Lateral Sclerosis risk by Ataxin-2 intermediate polyglutamine expansions is a specific effect
- 2012
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Ingår i: Neurobiology of Disease. - : Elsevier. - 0969-9961 .- 1095-953X. ; 45:1, s. 356-361
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Tidskriftsartikel (refereegranskat)abstract
- Full expansions of the polyglutamine domain (polyQ >= 34) within the polysome-associated protein ataxin-2 (ATXN2) are the cause of a multi-system neurodegenerative disorder, which usually presents as a Spino-Cerebellar Ataxia and is therefore known as SCA2, but may rarely manifest as Levodopa-responsive Parkinson syndrome or as motor neuron disease. Intermediate expansions (27 <= polyQ <= 33) were reported to modify the risk of Amyotrophic Lateral Sclerosis (ALS). We have now tested the reproducibility and the specificity of this observation. In 559 independent ALS patients from Central Europe, the association of ATXN2 expansions (30 <= polyQ <= 35) with ALS was highly significant. The study of 1490 patients with Parkinson's disease (PD) showed an enrichment of ATXN2 alleles 27/28 in a subgroup with familial cases, but the overall risk of sporadic PD was unchanged. No association was found between polyQ expansions in Ataxin-3 (ATXN3) and ALS risk. These data indicate a specific interaction between ATXN2 expansions and the causes of ALS, possibly through altered RNA-processing as a common pathogenic factor. (C) 2011 Elsevier Inc. All rights reserved.
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| 4. |
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| 5. |
- McCarty, Justin, et al.
(författare)
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Do we need a saw? Carbon-based analysis of facade BIPV performance under partial shading from nearby trees
- 2023
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Ingår i: Journal of Physics: Conference Series. - 1742-6588 .- 1742-6596. ; 2600:4
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Konferensbidrag (refereegranskat)abstract
- Building integrated photovoltaics (BIPV) are becoming more common in urban spaces. The impact of shading from nearby trees on BIPV performance and the potential conflict between the carbon sequestration benefits of trees and the carbon mitigation benefits of BIPV is not well documented in research. Therefore, this paper investigates the cost-benefit relationship of the carbon storage potential of trees vs. their shading effects on a nearby BIPV facade from the perspective of a life cycle assessment (LCA) using a high-resolution BIPV model and temporally sensitive tree growth model. The study is based on a typical Swiss residential building with adjacent vegetation and includes various BIPV facade permutations with different cell types, module orientations, inverter types, facade azimuths, grid emissions profiles, and tree planting scenarios. The results indicate that the removal of trees does not necessarily influence the overall carbon balance when considering LCA to the same degree as other features of the model space such as the grid carbon intensity or the configuration of the BIPV array. Furthermore the parametric-based analysis enables reporting on which BIPV configurations operate with the highest system efficiency under partial shading.
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| 6. |
- Weishaupt, Jochen H, et al.
(författare)
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A novel optineurin truncating mutation and three glaucoma-associated missense variants in patients with familial amyotrophic lateral sclerosis in Germany
- 2013
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Ingår i: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 34:5, s. 1516.e9-1516.e15
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Tidskriftsartikel (refereegranskat)abstract
- Mutations in the optineurin (OPTN) gene have been associated with normal tension glaucoma and with amyotrophic lateral sclerosis (ALS). Here, we screened German familial ALS cases for OPTN mutations to gain additional insight into the spectrum and pathogenic relevance of this gene for ALS. One hundred familial German ALS cases and 148 control subjects were screened for OPTN mutations by sequence analysis of the complete OPTN coding sequence, and phenotypes of OPTN mutant patients were described. We identified a novel heterozygous truncating OPTN mutation p.Lys440Asnfs*8 in 1 ALS family with an aggressive ALS disease phenotype. This mutation abolishes protein domains crucial for nuclear factor kappa B signaling. Moreover, we detected 3 different nonsynonymous sequence variants, which have been described previously as risk factors for primary retinal ganglion cell degeneration in normal tension glaucoma. Two of them were detected on the same allele in a family that also carries a p.Asn352Ser disease mutation in the ALS gene TARDBP. All OPTN mutant patients presented with typical spinal onset ALS. Taken together, we detected a novel truncating OPTN mutation associated with an aggressive form of ALS and confirmed that OPTN mutations are a rare cause of ALS. In addition our data suggest that in some cases plausibly more than 1 mutation in OPTN or another ALS gene might be needed to cause ALS. Finally, our findings show that motoneurons and retinal ganglion cells, which are both projecting central nervous system neurons, might share common susceptibility factors. (C) 2013 Elsevier Inc. All rights reserved.
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