| 1. |
|
|
| 2. |
|
|
| 3. |
- Vujasinovic, M, et al.
(författare)
-
Risk of Developing Pancreatic Cancer in Patients with Chronic Pancreatitis
- 2020
-
Ingår i: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 9:11
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Patients with chronic pancreatitis (CP) have an increased risk of developing pancreatic ductal adenocarcinoma (PDAC). We present data on PDAC in one of the most extensive European single-centre cohort studies of patients with CP. Methods: Retrospective analysis of prospectively collected data of patients with CP was performed. Aetiology of CP was determined according to the M-ANNHEIM classification system and only patients with definite CP > 18 years at data analysis were included. The final dataset included 581 patients with definite CP diagnosed between 2003 and 2018. Results: At CP diagnosis, there were 371 (63.9%) males and 210 (36.1%) females (median age 57 years, range 2–86). During 3423 person-years of observation, six pancreatic cancers were diagnosed (0.2% year). The mean time between diagnosis of CP and the occurrence of PDAC was 5.0 years (range 2.7–8.6). None of the cancer patients had a family history of PDAC. Diabetes mellitus (DM) was present in five of six (83.3%) patients with PDAC: in three patients before and in two after CP diagnosis. Clinical/laboratory signs of pancreatic exocrine insufficiency (PEI) were present in five of six (83.3%) patients with PDAC: in two at diagnosis of CP and in three after diagnosis. The mean survival time was 4 months after the diagnosis of PDAC (range 0.5–13). PDAC occurred significantly more often (p < 0.001) in two groups of patients without previous acute pancreatitis (AP): 2 of 20 patients (10%) with low body mass index (BMI) and PEI and in 3 of 10 (30%) patients with high BMI and DM at diagnosis of CP. Conclusions: Patients with CP have a high risk of developing PDAC, although risk is low in absolute terms. Our data suggest the possibility of defining subgroups of patients with a particularly elevated risk of PDAC. Such a possibility would open a path to personalised decision making on initiation of PDAC surveillance of patients with no previous episode of AP, (i) with low BMI and PEI, or (ii) elevated BMI and DM.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Hansson, MR, et al.
(författare)
-
BIMODAL ERCP, A NEW WAY OF SEEING THINGS
- 2019
-
Ingår i: GASTROINTESTINAL ENDOSCOPY. - : Elsevier BV. - 0016-5107. ; 89:6, s. AB249-AB250
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
|
|
| 7. |
- Valente, R, et al.
(författare)
-
Conservative Treatment of Chronic Pancreatitis: A Practical Approach
- 2020
-
Ingår i: Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society. - : SAGE Publications. - 1799-7267. ; 109:1, s. 59-68
-
Tidskriftsartikel (refereegranskat)abstract
- Chronic pancreatitis is a long-standing, inflammatory condition of the pancreas that leads to the progressive damage and loss of function of pancreatic parenchyma and to the development of possible locoregional and systemic medical complications. Materials and methods: In this review, we tried to summarize the current evidence on non-surgical treatment trying to suggest a practical approach to the management of chronic pancreatitis. Results: Besides the unclear pathophysiological mechanism and a poorly unknown epidemiology, chronic pancreatitis is a complex syndrome that displays different possible challenges for physicians. Despite being traditionally considered as a benign disease, chronic pancreatitis encompasses 10-year mortality rates which are superior to the ones reported for some of the most common cancers. Conclusions: Chronic pancreatitis encompasses the management of multiple and complex medical co-morbidities that needs to be understood and addressed in a multidisciplinary specialist context.
|
|
| 8. |
- Waldthaler, A, et al.
(författare)
-
Endoscopic and Conservative Management of Chronic Pancreatitis and Its Complications
- 2019
-
Ingår i: Visceral medicine. - : S. Karger AG. - 2297-4725 .- 2297-475X. ; 35:2, s. 98-108
-
Tidskriftsartikel (refereegranskat)abstract
- Chronic pancreatitis is a progressive inflammatory disease of the pancreas potentially giving rise to several complications. For this reason, patients need long-term care and treatment by medical, interventional, and sometimes surgical measures. This article reviews current state-of-the-art strategies and guidelines for treating chronic pancreatitis with conventional and endoscopic measures.
|
|
| 9. |
|
|
| 10. |
- Waldthaler, A, et al.
(författare)
-
Radiation dose in cone beam CT guided ERCP
- 2020
-
Ingår i: European journal of radiology. - : Elsevier BV. - 1872-7727 .- 0720-048X. ; 123, s. 108789-
-
Tidskriftsartikel (refereegranskat)
|
|
