| 1. |
- Hollmark, Malin, et al.
(författare)
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A comparison of radiobiological models for light ion therapy
- 2007
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Ingår i: The 11th Workshop of Ion Beams in Biology and Medicine, 25-29 September 2007, Heidelberg, Germany, ISSN 1013-4506, p. 47 (2007).
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Konferensbidrag (populärvet., debatt m.m.)abstract
- Treatment planning for light ion therapy requires development of radiobiological models describing the effects of light ion irradiation on cellular survival. The aim of this work is to compare some of these radiobiological models currently in use. The benchmark cell line used in these studies is an AA human melanoma cell line, irradiated in vitro under aerobic conditions by 60Co and 10B5+ ions of different values of linear energy transfer (40, 80, 125 and 160 keV/μm). The models used to analyze the data were: the standard linear-quadratic (LQ) model, the repairable-conditionally repairable (RCR) model, the probabilistic two-stage (P2S) model, Katz’s cellular track structure theory (TST), and the local effect model (LEM).
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| 2. |
- Grzanka, Leszek, et al.
(författare)
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THE ROLE OF PARTICLE SPECTRA IN MODELING THE RELATIVE BIOLOGICAL EFFECTIVENESS OF PROTON RADIOTHERAPY BEAMS
- 2019
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Ingår i: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 0144-8420 .- 1742-3406. ; 183:1-2, s. 251-254
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Tidskriftsartikel (refereegranskat)abstract
- Radiotherapy beams of protons or heavier ions generate secondary particles through nuclear interactions over different patient tissues. The resulting particle spectra depend on the tissue composition and on charge and energy of the primary beam ions. In proton radiotherapy, predictive radiobiological models usually apply dose-averaged linear energy transfer (LET). Microdosimetry-based models for proton or heavier ion primary beams also rely on dose-averaged quantities, the values of which depend on whether the produced secondaries are included or excluded in the calculation. In turn, this will affect the results of calculations of the relative biological effectiveness (RBE) of these beams. In this brief note, we study quantitatively the influence of the secondary radiation spectra on the averaged expectation values of LET and their impact on predictions of RBE. It is noted that for microdosimetry-based quantities and for corresponding LET-based parameters the trends are similar and that fluence-averaged quantities should be studied more closely.
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| 3. |
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| 4. |
- Waligórski, Michael P R, et al.
(författare)
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Cellular parameters and RBE-LET dependences for modelling heavy-ion radiotherapy.
- 2004
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Ingår i: Radiother Oncol. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 73:Supplement 2, s. S173-175
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Tidskriftsartikel (refereegranskat)abstract
- Sets of four parameters (m, Eo, ~o and •) of the cellular track structure model of Katz have been fitted to recently published dataconcerning human melanoma (AA) and mammalian (V79) cells exposed to a variety of lighter ions and to mixed ion-Co60 and ionionirradiation. We discuss the predictive capability of this model and propose standards in reporting cellular radiobiology data forapplication in modelling heavy ion beam radiotherapy.
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