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- Botvinik-Nezer, Rotem, et al.
(författare)
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Variability in the analysis of a single neuroimaging dataset by many teams
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 582, s. 84-88
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Tidskriftsartikel (refereegranskat)abstract
- Data analysis workflows in many scientific domains have become increasingly complex and flexible. Here we assess the effect of this flexibility on the results of functional magnetic resonance imaging by asking 70 independent teams to analyse the same dataset, testing the same 9 ex-ante hypotheses(1). The flexibility of analytical approaches is exemplified by the fact that no two teams chose identical workflows to analyse the data. This flexibility resulted in sizeable variation in the results of hypothesis tests, even for teams whose statistical maps were highly correlated at intermediate stages of the analysis pipeline. Variation in reported results was related to several aspects of analysis methodology. Notably, a meta-analytical approach that aggregated information across teams yielded a significant consensus in activated regions. Furthermore, prediction markets of researchers in the field revealed an overestimation of the likelihood of significant findings, even by researchers with direct knowledge of the dataset(2-5). Our findings show that analytical flexibility can have substantial effects on scientific conclusions, and identify factors that may be related to variability in the analysis of functional magnetic resonance imaging. The results emphasize the importance of validating and sharing complex analysis workflows, and demonstrate the need for performing and reporting multiple analyses of the same data. Potential approaches that could be used to mitigate issues related to analytical variability are discussed. The results obtained by seventy different teams analysing the same functional magnetic resonance imaging dataset show substantial variation, highlighting the influence of analytical choices and the importance of sharing workflows publicly and performing multiple analyses.
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| 2. |
- Broekman, Maarten J. E., et al.
(författare)
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Evaluating expert-based habitat suitability information of terrestrial mammals with GPS-tracking data
- 2022
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Ingår i: Global Ecology and Biogeography. - : Wiley. - 1466-822X .- 1466-8238. ; 31:8, s. 1526-1541
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Tidskriftsartikel (refereegranskat)abstract
- Aim: Macroecological studies that require habitat suitability data for many species often derive this information from expert opinion. However, expert-based information is inherently subjective and thus prone to errors. The increasing availability of GPS tracking data offers opportunities to evaluate and supplement expert-based information with detailed empirical evidence. Here, we compared expert-based habitat suitability information from the International Union for Conservation of Nature (IUCN) with habitat suitability information derived from GPS-tracking data of 1,498 individuals from 49 mammal species.Location: Worldwide.Time period: 1998-2021.Major taxa studied: Forty-nine terrestrial mammal species.Methods: Using GPS data, we estimated two measures of habitat suitability for each individual animal: proportional habitat use (proportion of GPS locations within a habitat type), and selection ratio (habitat use relative to its availability). For each individual we then evaluated whether the GPS-based habitat suitability measures were in agreement with the IUCN data. To that end, we calculated the probability that the ranking of empirical habitat suitability measures was in agreement with IUCN's classification into suitable, marginal and unsuitable habitat types.Results: IUCN habitat suitability data were in accordance with the GPS data (> 95% probability of agreement) for 33 out of 49 species based on proportional habitat use estimates and for 25 out of 49 species based on selection ratios. In addition, 37 and 34 species had a > 50% probability of agreement based on proportional habitat use and selection ratios, respectively.Main conclusions: We show how GPS-tracking data can be used to evaluate IUCN habitat suitability data. Our findings indicate that for the majority of species included in this study, it is appropriate to use IUCN habitat suitability data in macroecological studies. Furthermore, we show that GPS-tracking data can be used to identify and prioritize species and habitat types for re-evaluation of IUCN habitat suitability data.
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| 3. |
- Margaryan, Lusine
(författare)
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Commercialization of nature through tourism
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation contributes to developing knowledge on the commercialization of natural resources through tourism. This is achieved by means of understanding the main avenues through which natural resources are commercialized, and analyzing the operational setting of tourism firms. The focal area is nature-based tourism– a type of tourism, taking place incomparatively unmodified natural areas, which has emerged as a powerful gravitational force, integrating an increasing variety of natural resources into the commercial domain. The point of departure is the assumption that fornature-based tourism firms, nature is simultaneously the main object of commercialization and the operational setting, where this commercialization happens. The attention here is, therefore, on the supply side, i.e. on the smalland micro firms, acting as the agents of commercialization. The empirical data come primarily from a nation-wide survey among the nature-based tourism firms in Sweden, generating the most comprehensive information about this sector to date. Additional data come from in-depth interviews and observations among the nature-based tourism firms in Sweden, as well assecondary sources (official statistics on natural resources and a survey in Norway).This is a compilation thesis, i.e. it consists of a cover essay and five individual papers. The cover essay offers a bird’s eye view on all the papers, frames them theoretically and synthesizes all the findings into a coherent contribution. Papers I and II create the foundation, necessary for understanding the processes of nature commercialization and the operational setting of naturebased tourism firms, while Papers III, IV and V provide supplementary insights into these areas of inquiry. Paper I starts by building on existing knowledge in outdoor recreation to approach nature-based tourism. Paper II focuses on the operational setting, conceptualizes and explores its dimensions. Building on this, Paper III looks at how the presence of various amenities in the operational setting can explain the localization patterns of the firms on various geographical levels. Paper IV focuses on the operational setting dimensions omitted in the previous papers, i.e. the continuous efforts of the firms to negotiate the inherent uncertainty within the setting. Finally, Paper V looks at various characteristics of nature-based tourism firms to understand the specifics of sustainability strategies.The main findings in these five papers demonstrate that the nature-basedtourism is an active integrator of a wide variety of natural resources into the commercial domain, and approaching them from the supply perspective provides an additional understanding of the sector. This approach suggests that the nature-based tourism supply could be understood not only from the perspectives of tourist activities offered, but also from the perspective of operational setting preferences (e.g., the axes of high-low specialization, and high-low dependence on specific setting features), providing a new insight into the ways of nature commercialization through tourism. The operational setting itself becomes an important resource, being simultaneously part of the supply and the environment of a tourism system, bringing together a multitude of dimensions and actors. The resources nature-based tourism depends on defy ‘commercialization-friendly’ criteria, creating a context of uncertainty and demanding higher levels of creativity and agency on behalf of the firms. Commercialized nature experiences become important not only for specialized, skill- and equipment-intensive activities, but also for rather simple and relaxed ones, on both international and domestic markets. This suggests the growing importance of commercial nature-based tourism, linked to growing sustainability challenges. The sustainable resource use within the Scandinavian nature-based tourism context, however, is deeply entrenched inunique local specifics, and the entrepreneurial characteristics are not always compatible with market-based sustainability policies, suggesting the need for more fine-tuned approaches.
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| 4. |
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| 5. |
- Trovik, Clement, et al.
(författare)
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The Scandinavian Sarcoma Group Central Register: 6,000 patients after 25 years of monitoring of referral and treatment of extremity and trunk wall soft-tissue sarcoma
- 2017
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Ingår i: Acta Orthopaedica. - : TAYLOR & FRANCIS LTD. - 1745-3674 .- 1745-3682. ; 88:3, s. 341-347
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Tidskriftsartikel (refereegranskat)abstract
- Purpose - We wanted to examine the potential of the Scandinavian Sarcoma Group (SSG) Central Register, and evaluate referral and treatment practice for soft-tissue sarcomas in the extremities and trunk wall (STS) in the Nordic countries. Background - Based on incidence rates from the literature, 8,150 (7,000-9,300) cases of STS of the extremity and trunk wall should have been diagnosed in Norway, Finland, Iceland, and Sweden from 1987 through 2011. The SSG Register has 6,027 cases registered from this period, with 5,837 having complete registration of key variables. 10 centers have been reporting to the Register. The 5 centers that consistently report treat approximately 90% of the cases in their respective regions. The remaining centers have reported all the patients who were treated during certain time periods, but not for the entire 25-year period. Results - 59% of patients were referred to a sarcoma center untouched, i.e. before any attempt at open biopsy. There was an improvement from 52% during the first 5 years to 70% during the last 5 years. 50% had wide or better margins at surgery. Wide margins are now achieved less often than 20 years ago, in parallel with an increase in the use of radiotherapy. For the centers that consistently report, 97% of surviving patients are followed for more than 4 years. Metastasis-free survival (MFS) increased from 67% to 73% during the 25-year period. Interpretation - The Register is considered to be representative of extremity and trunk wall sarcoma disease in the population of Scandinavia, treated at the reporting centers. There were no clinically significant differences in treatment results at these centers.
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| 6. |
- Williams, David J., et al.
(författare)
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Comparability : Manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015
- 2016
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Ingår i: Regenerative Medicine. - : Future Medicine Ltd. - 1746-0751 .- 1746-076X. ; 11:5, s. 483-492
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Tidskriftsartikel (refereegranskat)abstract
- This paper summarizes the proceedings of a workshop held at Trinity Hall, Cambridge to discuss comparability and includes additional information and references to related information added subsequently to the workshop. Comparability is the need to demonstrate equivalence of product after a process change; a recent publication states that this 'may be difficult for cell-based medicinal products'. Therefore a well-managed change process is required which needs access to good science and regulatory advice and developers are encouraged to seek help early. The workshop shared current thinking and best practice and allowed the definition of key research questions. The intent of this report is to summarize the key issues and the consensus reached on each of these by the expert delegates.
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