| 1. |
- Hoffland, Ellis, et al.
(författare)
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The role of fungi in weathering
- 2004
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Ingår i: Frontiers in Ecology and Environment. - 1540-9295 .- 1540-9309. ; 2:5, s. 258-264
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Tidskriftsartikel (refereegranskat)abstract
- No rock at the Earth’s surface escapes weathering. This process is the primary source of all the essential elements for organisms, except nitrogen and carbon. Since the onset of terrestrial life, weathering has been accelerated under the influence of biota. The study of biological weathering started at the end of the 19th century. Although the role of bacteria (Eubacteria, Archaea) has attracted a lot of interest, until recently the role of fungi has largely been neglected. More recently, however, fungal weathering has become an increasingly important focus of biogeochemical research.
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| 2. |
- Nilsson, Anna G, 1968, et al.
(författare)
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Type 2 Diabetes Mellitus is Associated with Better Bone Microarchitecture But Lower Bone Material Strength and Poorer Physical Function in Elderly Women - a Population-Based Study.
- 2017
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Ingår i: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. - : Wiley. - 1523-4681. ; 32:5
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Tidskriftsartikel (refereegranskat)abstract
- Type 2 diabetes mellitus (T2DM) is associated with an increased risk of fractures according to several studies. The underlying mechanisms remain unclear, although small case-control studies indicate poor quality of the cortical bone. We have studied a population-based sample of women aged 75-80 in Gothenburg, randomly invited from the population registry. Areal bone mineral density (aBMD) was measured by dual energy x-ray absorptiometry (Hologic Discovery A), bone microarchitecture by high-resolution peripheral quantitative computed tomography (HR-pQCT; ExtremeCT from Scanco Medical AG), and reference point indentation was performed with Osteoprobe (Active Life Scientific). Women with T2DM (n=99) had higher aBMD compared to controls (n=954). Ultradistal tibial and radial trabecular bone volume fraction (+11% and +15%, respectively), distal cortical volumetric BMD (+1.6% and +1.7%), cortical area (+11.5% and +9.3%), and failure load (+7.7% and +12.9%) were higher in diabetics than in controls. Cortical porosity was lower (mean±SD: 1.5±1.1 vs 2.0±1.7%, p=0.001) in T2DM in the distal radius but not in the ultradistal radius or the tibia. Adjustment for covariates (age, body mass index, glucocorticoid treatment, smoking, physical activity, calcium intake, bone-active drugs) eliminated the differences in aBMD but not in HR-pQCT bone variables. However, bone material strength index (BMSi) by reference point indentation was lower in T2DM (74.6±7.6 vs 78.2±7.5, p<0.01), also after adjustment, and women with T2DM performed clearly worse in measures of physical function (one leg standing: -26%, 30s chair-stand test: -7%, timed up and go: +12%, walking speed: +8%; p<0.05-0.001) compared to controls. In conclusion, we observed a more favorable bone microarchitecture but no difference in adjusted aBMD in elderly women with T2DM in the population compared to non-diabetics. Reduced BMSi and impaired physical function may explain the increased fracture risk in T2DM. This article is protected by copyright. All rights reserved.
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| 3. |
- Wallander, Karin, et al.
(författare)
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Sensitive Detection of Cell-Free Tumour DNA Using Optimised Targeted Sequencing Can Predict Prognosis in Gastro-Oesophageal Cancer
- 2023
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 15:4, s. 1160-
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Tidskriftsartikel (refereegranskat)abstract
- Simple Summary Cancer in the stomach and oesophagus is deadly when discovered at a late stage. There are no good biomarkers for its detection or for making a prognostic prediction. In this study, we evaluate the analysis of cell-free DNA as a prognostic cancer biomarker. Cell-free DNA is DNA released from any tissue to a body fluid. When there is a tumour in the body, some of the cell-free DNA will come from that tumour, and it can be detected in a blood sample. We show that the detection of cell-free DNA from the cancer correlates to a worse prognosis than when no tumour DNA is detected. We also show that the method of analysis is important. Either a tissue biopsy must be included as a validation of the genetic variants detected or analysis of the blood cells or another blood sample after tumour resection needs to be analysed to improve detection. In this longitudinal study, cell-free tumour DNA (a liquid biopsy) from plasma was explored as a prognostic biomarker for gastro-oesophageal cancer. Both tumour-informed and tumour-agnostic approaches for plasma variant filtering were evaluated in 47 participants. This was possible through sequencing of DNA from tissue biopsies from all participants and cell-free DNA from plasma sampled before and after surgery (n = 42), as well as DNA from white blood cells (n = 21) using a custom gene panel with and without unique molecular identifiers (UMIs). A subset of the plasma samples (n = 12) was also assayed with targeted droplet digital PCR (ddPCR). In 17/31 (55%) diagnostic plasma samples, tissue-verified cancer-associated variants could be detected by the gene panel. In the tumour-agnostic approach, 26 participants (59%) had cancer-associated variants, and UMIs were necessary to filter the true variants from the technical artefacts. Additionally, clonal haematopoietic variants could be excluded using the matched white blood cells or follow-up plasma samples. ddPCR detected its targets in 10/12 (83%) and provided an ultra-sensitive method for follow-up. Detectable cancer-associated variants in plasma correlated to a shorter overall survival and shorter time to progression, with a significant correlation for the tumour-informed approaches. In summary, liquid biopsy gene panel sequencing using a tumour-agnostic approach can be applied to all patients regardless of the presence of a tissue biopsy, although this requires UMIs and the exclusion of clonal haematopoietic variants. However, if sequencing data from tumour biopsies are available, a tumour-informed approach improves the value of cell-free tumour DNA as a negative prognostic biomarker in gastro-oesophageal cancer patients.
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| 4. |
- Andersson, Rasmus, et al.
(författare)
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Klimat- och energieffekter vid renoverings- och ombyggnadsprojekt : Stöd för utvärdering och beslut baserat på sammantagna klimatmässiga effekter
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Byggnaders klimatpåverkan har lyfts fram mer och mer under de senaste decennierna. Med en större förståelse för en byggnads klimatpåverkan har det inom nyproduktion blivit enklare att sätta mål för att minska byggskedets klimatpåverkan. Detta baserat på mer kunskap och erfarenhet från genomförda klimatberäkningar samt större tillgång till offentliga resultat för såväl typiska som mer innovativa byggprojekt. För klimatpåverkan från renoverings- och ombyggnationsprojekt är kunskapsläget lägre än för nyproduktion. Livscykelanalyser och klimatberäkningar är inte lika vanliga och det saknas tillgång till offentliga resultat att jämföra sig med. Då renoverings- och ombyggnationsprojekt även innebär utsläpp av växthusgaser finns här ett behov av ökad kunskap.Vid renovering och ombyggnation är det inte ovanligt att en byggnads energiprestanda förändras som följd av projektet. Den förändrade energianvändningen resulterar i lägre eller högre klimatutsläpp under kommande drift. Byggnadens energianvändning blir därmed en viktig parameter vid bedömning av klimatnyttan av ett renoverings- eller ombyggnationsprojekt. För att fatta bra klimatbeslut och bättre kunna beakta klimatpåverkan vid renoverings- och ombyggnationsprojekt behöver kunskapen öka. Denna rapport avser att bidra till denna kunskapsökning bland annat genom publicering av resultat från genomförda klimatberäkningar. Detta tillsammans med ökad kunskap om hur förändrad energianvändning kan inkluderas vid bedömning av genomförda åtgärder.
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| 5. |
- Bahr, Adam, et al.
(författare)
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Growth of ectomycorrhizal fungal mycelium along a Norway spruce forest nitrogen deposition gradient and its effect on nitrogen leakage
- 2013
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Ingår i: Soil Biology and Biochemistry. - : Elsevier BV. - 0038-0717 .- 1879-3428. ; 59, s. 38-48
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Tidskriftsartikel (refereegranskat)abstract
- Almost all boreal and temperate forest tree species live in symbiosis with ectomycorrhizal fungi (EMF); the trees transfer carbon (C) to the fungi in exchange for nutrients and water. Several studies have shown that experimental application of inorganic nitrogen (N) represses production of EMF extramatrical mycelia (EMM), but studies along N deposition gradients are underrepresented. Other environmental variables than N may influence EMM production and in this study we included 29 thoroughly monitored Norway spruce stands from a large geographical region in Sweden in order to evaluate the importance of N deposition on EMM growth and N leaching in a broader context. It was concluded that N deposition was the most important factor controlling EMM production and that the amounts typically deposited in boreal and boreo-nemoral regions can be sufficient to reduce EMM growth. Other factors, such as phosphorus status and pH, were also correlated with EMM production and should be considered when predicting EMM growth and N leaching. We also showed that EMM production substantially contributed to the C sequestration (320 kg ha(-1) yr(-1)), suggesting that it should be included in C cycle modelling. Furthermore, EMF are probably important for the N retention capacity since high N leaching coincided with low EMM growth. However, it was not possible to differentiate between the effects of EMF and the direct effect of N deposition on N leaching in the present study.
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| 6. |
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| 7. |
- Cea Soriano, Lucía, et al.
(författare)
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The continuation rates of long-acting reversible contraceptives in UK general practice using data from The Health Improvement Network
- 2015
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Ingår i: Pharmacoepidemiology and Drug Safety. - : Wiley. - 1053-8569 .- 1099-1557. ; 24:1, s. 52-58
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The purpose of this study was to determine the continuation rates of new users of long-acting reversible contraceptive (LARC) methods in the UK, using data from general practice.METHODS: We conducted an observational study using a general practitioner (GP) database, The Health Improvement Network (THIN). The methods studied were copper intrauterine devices (Cu-IUDs), levonorgestrel-releasing intrauterine system (LNG-IUS), progestogen-only implants and progestogen-only injections. The study population comprised women in THIN aged 18-44 years during the period 2004-2009 who had been registered with their GP for at least 5 years, with a computerized prescription history of at least 1 year. Using computer algorithms, the database was searched for the Read and Multilex codes for each LARC method. New LARC users were identified and followed until there was a record indicating termination of use or the study period ended.RESULTS: The proportion of women who discontinued use during the same year of administration was 7.5% for Cu-IUDs, 10.6% for LNG-IUS, 13.2% for progestogen-only implants and 54.4% for progestogen-only injections. By the end of the study, a higher proportion of Cu-IUD and LNG-IUS users (21.1 and 18.6%, respectively) undertook consecutive use of the same method than progestogen-only implant users (10.7%). Manual review of computerized profiles demonstrated the validity of this approach.CONCLUSIONS: In the UK, the continuation rates of LARCs are high, and approximately one fifth of women chose to have a second intrauterine device fitted after expiry of the first device. A validation step demonstrated the reliability of the methodology and computer algorithms used.
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| 8. |
- Cea Soriano, Lucía, et al.
(författare)
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Use of long-acting reversible contraceptives in the UK from 2004 to 2010 : Analysis using The Health Improvement Network Database
- 2014
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Ingår i: European journal of contraception & reproductive health care. - : Informa UK Limited. - 1362-5187 .- 1473-0782. ; 19:6, s. 439-447
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Tidskriftsartikel (refereegranskat)abstract
- Objectives To determine the use of long-acting reversible contraceptives (LARCs) in the UK over the period 2004 to 2010, using the general practice database The Health Improvement Network (THIN).Methods Women in THIN, aged 18 to 44 years during 2004 to 2010, who had been registered with their general practitioner for at least five years, with a prescription history of at least one year were included. THIN was searched using the Read and MULTILEX codes for: copper intrauterine devices (Cu-IUDs), the levonorgestrel releasing-intrauterine system (LNG-IUS), progestogen-only implants, and progestogen-only injections.Results The prevalence of progestogen-only implant use rose from 0.5 to 3.4%, and that of the LNG-IUS from 3.1 to 5.2%. The annual incidence and prevalence of progestogen-only implant use increased for all age groups but was most marked in younger women, whereas the use of the LNG-IUS augmented with increasing age. For all women, there was a small decrease in the prevalence of use of Cu-IUDs (from 5.4 to 4.8%) and progestogen-only injections (from 3.6 to 3.2%).Conclusions Uptake of progestogen-only implants and the LNG-IUS increased over the period 2004 to 2010 in the UK, but LARC use in young women remains low.
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| 9. |
- Dahlby, Malin, et al.
(författare)
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Parent-child interaction: Relationship between pause duration and infant vocabulary at 18 months
- 2011
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Ingår i: Proceedings from Fonetik 2011. - Stockholm. ; , s. 101-104
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Studies of child language development have shown that children from an early age are aware of turn-taking patterns in interaction. The aim of this study is to investigate if there is a relationship between turn-taking pauses in parent-child interaction and child vocabulary at 18 months of age. Analysis of pause duration is conducted on recordings from the SPRINT language intervention project and pause duration is found to correlate with child vocabulary size. Different possible reasons for this correlation are discussed.
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| 10. |
- Ekblad, Alf, et al.
(författare)
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Production and turnover of ectomycorrhizal extramatrical mycelial biomass and necromass under elevated CO2 and nitrogen fertilization
- 2016
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Ingår i: New Phytologist. - Hoboken, USA : Wiley. - 0028-646X .- 1469-8137. ; 211:3, s. 874-885
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Tidskriftsartikel (refereegranskat)abstract
- Extramatrical mycelia (EMM) of ectomycorrhizal fungi are important in carbon (C) and nitrogen (N) cycling in forests, but poor knowledge about EMM biomass and necromass turnovers makes the quantification of their role problematic. We studied the impacts of elevated CO2 and N fertilization on EMM production and turnover in a Pinus taeda forest. EMM C was determined by the analysis of ergosterol (biomass), chitin (total bio- and necromass) and total organic C (TOC) of sand-filled mycelium in-growth bags. The production and turnover of EMM bio- and necromass and total C were estimated by modelling. N fertilization reduced the standing EMM biomass C to 57% and its production to 51% of the control (from 238 to 122 kg C ha-1 yr-1), whereas elevated CO2 had no detectable effects. Biomass turnover was high (~13 yr-1) and unchanged by the treatments. Necromass turnover was slow and was reduced from 1.5 yr-1 in the control to 0.65 yr-1 in the N-fertilized treatment. However, TOC data did not support an N effect on necromass turnover. An estimated EMM production ranging from 2.5 to 6% of net primary production stresses the importance of its inclusion in C models. A slow EMM necromass turnover indicates an importance in building up forest humus.
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