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- Fick, Jerker, et al.
(författare)
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Antiviral Oseltamivir is not removed or degraded in normal sewage water treatment : Implications for development of resistance by influenza A virus
- 2007
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 2:10, s. e986-
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Tidskriftsartikel (refereegranskat)abstract
- Oseltamivir is the main antiviral for treatment and prevention of pandemic influenza. The increase in oseltamivir resistance reported recently has therefore sparked a debate on how to use oseltamivir in non pandemic influenza and the risks associated with wide spread use during a pandemic. Several questions have been asked about the fate of oseltamivir in the sewage treatment plants and in the environment. We have assessed the fate of oseltamivir and discuss the implications of environmental residues of oseltamivir regarding the occurrence of resistance. A series of batch experiments that simulated normal sewage treatment with oseltamivir present was conducted and the UV-spectra of oseltamivir were recorded. Findings: Our experiments show that the active moiety of oseltamivir is not removed in normal sewage water treatments and is not degraded substantially by UV light radiation, and that the active substance is released in waste water leaving the plant. Our conclusion is that a ubiquitous use of oseltamivir may result in selection pressures in the environment that favor development of drug-resistance.
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- Potter, Richard, et al.
(författare)
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An evaluation of Substance Painter and Mari as visualisation methods using the Piraeus Lion and its runic inscriptions as a case study
- 2023
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Ingår i: Heritage Science. - 2050-7445. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- This paper explores the effectiveness in the use of texture painting software packages, which are more commonly used in the film and game industries, as a method for detecting and recording carvings on non-planar surfaces. This new approach is demonstrated through a case study of the Piraeus Lion, a sculpture in Venice which has documented engravings that are subtle and have proven difficult to fully recorded and interpret using traditional approaches. Through the creation of a new digital documentation of the Piraeus Lion using Structure from Motion, the model was processed using existing methods and other experimental visualisation techniques. The outputs from these were then compared to the those from two software, Substance Painter and Mari. These software packages helped to visualise the carvings and showed that the method has potential for a wide range of uses, both within epigraphy and other fields of study relating to carvings on stone including rock art and runology. The presented method is intended to be used alongside existing digital and analogue methods as a tool for annotating, evaluating, and discovering new carvings in their original context. In particular, Substance Painter offers a repeatable, easy to use, and intuitive solution to creating easily distributable visualisations and annotated models.
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