| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Ahlm, Clas, 1956-, et al.
(författare)
-
Serologic evidence of Puumala virus infection in wild moose in northern Sweden
- 2000
-
Ingår i: American Journal of Tropical Medicine and Hygiene. - : American Society of Tropical Medicine and Hygiene. - 0002-9637 .- 1476-1645. ; 62:1, s. 106-111
-
Tidskriftsartikel (refereegranskat)abstract
- Puumala (PUU) virus is the causative agent of nephropathia epidemica, the Scandinavian form of hemorrhagic fever with renal syndrome. The infection is acquired by airborne transmission of PUU virus from its rodent reservoir, the bank vole. Besides serologic data indicating that the virus may spread also to heterologous rodents, there is little information on the susceptibility of wild living animals to PUU virus. We studied the occurrence of antibodies to PUU virus in serum samples from 427 wild-living moose, of which 260 originated from the PUU virus-endemic northern and central parts of Sweden and 167 originated from the southern, nonendemic part of Sweden. Samples from 5 animals showed reactivity in an ELISA for recombinant PUU virus nucleocapsid protein, an immunofluorescent assay, and a neutralization test. These 5 animals all originated from the PUU virus-endemic northern part of Sweden. In conclusion, 5 of 260 moose from the endemic region showed convincing serologic evidence of past PUU virus infection. The seroprevalence was low, suggesting that the moose is subjected to endstage infection rather than being part of an enzootic transmission cycle.
|
|
| 6. |
|
|
| 7. |
- Almqvist, Fredrik, et al.
(författare)
-
Spirobicyclo[2.2.2]octane derivatives: mimetics of baccatin III and paclitaxel (Taxol)
- 2004
-
Ingår i: Organic & Biomolecular Chemistry. - : Royal Society of Chemistry (RSC). - 1477-0520 .- 1477-0539. ; 2:21, s. 3085-3090
-
Tidskriftsartikel (refereegranskat)abstract
- The formylated spirobyclic alcohol 8a was computer modeled to be a mimetic of paclitaxel. In this model, the formyl group was used as a truncated paclitaxel side chain in order to reduce the computational work. Compound 8c, carrying the paclitaxel side chain, was synthesized in six steps from optically active 1,3-diketone 12. Microtubule stabilization was not observed for 8c, indicating that the model needs to be adjusted.
|
|
| 8. |
- Almqvist, Fredrik, et al.
(författare)
-
Spirobicyclo[2.2.2]octane derivatives: mimetics of baccatin III and paclitaxel (Taxol)
- 2004
-
Ingår i: Organic and Biomolecular Chemistry. - 1477-0539. ; 2:21, s. 3085-3090
-
Tidskriftsartikel (refereegranskat)abstract
- The formylated spirobyclic alcohol 8a was computer modeled to be a mimetic of paclitaxel. In this model, the formyl group was used as a truncated paclitaxel side chain in order to reduce the computational work. Compound 8c, carrying the paclitaxel side chain, was synthesized in six steps from optically active 1,3-diketone 12. Microtubule stabilization was not observed for 8c, indicating that the model needs to be adjusted.
|
|
| 9. |
- Almqvist, Fredrik, et al.
(författare)
-
Spirobicyclo[2.2.2]octane derivatives: mimetics of baccatin III and paclitaxel (Taxol)
- 2004
-
Ingår i: ORGANIC & BIOMOLECULAR CHEMISTRY. - : Royal Society of Chemistry (RSC). - 1477-0520 .- 1477-0539. ; 2:21, s. 3085-90
-
Tidskriftsartikel (refereegranskat)abstract
- The formylated spirobyclic alcohol 8a was computer modeled to be a mimetic of paclitaxel. In this model, the formyl group was used as a truncated paclitaxel side chain in order to reduce the computational work. Compound 8c, carrying the paclitaxel side chain, was synthesized in six steps from optically active 1,3-diketone 12. Microtubule stabilization was not observed for 8c, indicating that the model needs to be adjusted.
|
|
| 10. |
- Arroyo, Carlos, 1977, et al.
(författare)
-
Experimental and Numerical Investigation of an Aggressive Intermediate Turbine Duct: Part 2−Flowfield under Off-Design Inlet Conditions
- 2008
-
Ingår i: Collection of Technical Papers - AIAA Applied Aerodynamics Conference. - Reston, Virigina : American Institute of Aeronautics and Astronautics. - 1048-5953.
-
Konferensbidrag (refereegranskat)abstract
- Intermediate turbine ducts (ITD’s) are annular S-shaped channels used in turbofan engines to guide the flow between the small-radius high-pressure turbine and the large-radius lowpressureturbine. This paper is the second part of a two-part paper presenting the results of acombined experimental and computational investigation of the flow in an aggressiveintermediate turbine duct. The first part of the paper focused on the flowfield under the ITDdesign conditions. This second part of the paper presents and analyses the flowfield andperformance under two off-design conditions (i.e. lower and higher turbine load). The focus ison the changes of the flowfield for these conditions as the inlet flow angles differ from thedesign values (e.g. flow separation occurs in the duct for the lower turbine load case) and theeffect of this change on the duct performance. Total pressure losses are seen to increase forboth off-design cases, especially for the case with flow separation (lower turbine load). Thestatic pressure recovery is also found to be lower for the case with flow separation while for thehigher turbine load tested it remains almost unchanged. In addition, differences foundbetween the measured and predicted performance parameters are discussed. The experimentalstudy was performed in a large-scale, low-speed turbine facility. The CFD computations wereperformed for the same flow conditions and used boundary conditions based on the measuredinlet plane.
|
|
