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| 2. |
- Kao-Walter, Sharon, et al.
(författare)
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A Comparison of 2-zone and 3-zone Models in Tearing based on Essential Work of Fracture
- 2009
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Konferensbidrag (refereegranskat)abstract
- Two different models (2-zone and 3-zone) for describing the deformation and fracture behavior of tearing ligament was compared and discussed based on the experimental results made by Kim et al. The models are based on the Essential Work of Fracture approach for predicting the specific total work of fracture along the tear path across plastic zones. The experiment and analysis were based on 2-leg trousers tear specimen. The materials chosen in this work were PET (0.508 mm). The results showed that the accuracy of 3-zone model was higher than 2-zone model. It was found that this difference is because the 2-zone model did not consider the plastic deformation caused by loading prior to tearing. Also a finite element model was created to simulate the behavior around the crack tip.
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| 3. |
- Kao-Walter, Sharon, et al.
(författare)
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Acoustic imaging internal microstructure of a packaging material
- 2008
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Konferensbidrag (refereegranskat)abstract
- Microstructure of a paper-based packaging material was studied by acoustic microscopy method. The laminate structure of the packaging material contains paperboard, polymer and aluminium, which are widely used for aseptic liquid food package. The method has also been used to detect delaminations inside the material. The results show the possibility to study the micro structural features of paperboard, polymer and aluminium foil layered materials by applying the high-resolution ultrasonic acoustic microscopy. The potential for visualization defects in the body of this kind of materials is discussed in order to further develop the Non-Destructive Testing (NDT) method in food packaging industries.
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| 4. |
- Kao-Walter, Sharon, et al.
(författare)
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Tearing and Delaminating of a Polymer Laminate
- 2011
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Ingår i: Key Engineering Materials. - : @scientific.net. - 1013-9826. ; 465, s. 169-174
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Tidskriftsartikel (refereegranskat)abstract
- The fracture behaviour of laminated materials was studied in this work. The materials used in this work were low-density polyethylene (LDPE) laminated on polyethylene (PET). The thickness of the LDPE was 27 μm and the PET was 100 μm. Experiments were performed by using a 2-leg trousers specimen to analyse the tearing behaviour of the laminate in relation to the delamination. A clear delamination zone was observed during the crack propagation by tearing. Furthermore, a finite element calculation was performed to simulate the behavior around the crack tip during the tearing. A correlation between adhesion and crack propagation was discussed. Finally, the theory of Essential Work of Fracture (EWF) was used for predicting the specific total work of fracture along the tear path across the plastic zones.
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| 5. |
- Kao-Walter, Sharon, et al.
(författare)
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Tensile and Tearing Fracture Behaviour of Food Packaging Laminate
- 2007
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Fracture behaviour of laminated food packaging materials is studied. The materials used in this work were the single layer of Aluminium foil (Al-foil), Low density polyethylene (LDPE) and the lamination of these single layers. Experiments were performed by applying the centred crack specimen as well as the 2-leg trousers specimen. It was observed that the load carrying capacity increased for the tensile and decreased for the tearing specimen when the two layers are laminated together. It was also found that in the case of tearing the crack growth was not only initiated by shear stress but also by normal stress. A modified strip yield model and the essential work of fracture theory were used to analyze the deformation and the fracture behaviour. The initial crack growth of the single layers and the laminate during the tensile and tearing were compared and investigated.
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| 6. |
- Adamo, Christin S., et al.
(författare)
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EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis
- 2022
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Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297. ; 109:12, s. 2230-2252
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Tidskriftsartikel (refereegranskat)abstract
- EMILIN1 (elastin-microfibril-interface-located-protein-1) is a structural component of the elastic fiber network and localizes to the interface between the fibrillin microfibril scaffold and the elastin core. How EMILIN1 contributes to connective tissue integrity is not fully understood. Here, we report bi-allelic EMILIN1 loss-of-function variants causative for an entity combining cutis laxa, arterial tortuosity, aneurysm formation, and bone fragility, resembling autosomal-recessive cutis laxa type 1B, due to EFEMP2 (FBLN4) deficiency. In both humans and mice, absence of EMILIN1 impairs EFEMP2 extracellular matrix deposition and LOX activity resulting in impaired elastogenesis, reduced collagen crosslinking, and aberrant growth factor signaling. Collagen fiber ultrastructure and histopathology in EMILIN1- or EFEMP2-deficient skin and aorta corroborate these findings and murine Emilin1-/- femora show abnormal trabecular bone formation and strength. Altogether, EMILIN1 connects elastic fiber network with collagen fibril formation, relevant for both bone and vascular tissue homeostasis.
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| 7. |
- Allum, F., et al.
(författare)
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A localized view on molecular dissociation via electron-ion partial covariance
- 2022
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Ingår i: Communications Chemistry. - : Springer Science and Business Media LLC. - 2399-3669. ; 5:1
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Tidskriftsartikel (refereegranskat)abstract
- Inner-shell photoelectron spectroscopy provides an element-specific probe of molecular structure, as core-electron binding energies are sensitive to the chemical environment. Short-wavelength femtosecond light sources, such as Free-Electron Lasers (FELs), even enable time-resolved site-specific investigations of molecular photochemistry. Here, we study the ultraviolet photodissociation of the prototypical chiral molecule 1-iodo-2-methylbutane, probed by extreme-ultraviolet (XUV) pulses from the Free-electron LASer in Hamburg (FLASH) through the ultrafast evolution of the iodine 4d binding energy. Methodologically, we employ electron-ion partial covariance imaging as a technique to isolate otherwise elusive features in a two-dimensional photoelectron spectrum arising from different photofragmentation pathways. The experimental and theoretical results for the time-resolved electron spectra of the 4d(3/2) and 4d(5/2) atomic and molecular levels that are disentangled by this method provide a key step towards studying structural and chemical changes from a specific spectator site. Coincidence experiments at free-electron lasers enable time resolved site-specific investigations of molecular photochemistry at high signal rates, but isolating individual dissociation processes still poses a considerable technical challenge. Here, the authors use electron-ion partial covariance imaging to isolate otherwise elusive chemical shifts in UV-induced photofragmentation pathways of the prototypical chiral molecule 1-iodo-2-methylbutane.
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| 8. |
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| 9. |
- Armstrong, Andrew J, et al.
(författare)
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Assessment of the bone scan index in a randomized placebo-controlled trial of tasquinimod in men with metastatic castration-resistant prostate cancer (mCRPC).
- 2014
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Ingår i: Urologic oncology. - : Elsevier BV. - 1873-2496. ; 32:8, s. 1308-1316
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Tidskriftsartikel (refereegranskat)abstract
- Drug development and clinical decision making for patients with metastatic prostate cancer (PC) have been hindered by a lack of quantitative methods of assessing changes in bony disease burden that are associated with overall survival (OS). Bone scan index (BSI), a quantitative imaging biomarker of bone tumor burden, is prognostic in men with metastatic PC. We evaluated an automated method for BSI calculation for the association between BSI over time with clinical outcomes in a randomized double-blind trial of tasquinimod (TASQ) in men with metastatic castration-resistant PC (mCRPC).
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| 10. |
- Bednarska, Olga, et al.
(författare)
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Neurotransmittor Concentration in Pregenual ACC in Stool Consistency Patient Subgroups With IBS
- 2014
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Konferensbidrag (refereegranskat)abstract
- IntroductionThe Anterior Cingulate Cortex (ACC) is a key region of the central autonomic brain network. Irritable Bowel Syndrome (IBS) is characterized abdominal pain and bowel habit disturbances. Autonomic dysregulation has been reported in IBS as well as altered ACC activation in pregenual ACC during visceral stimulation 1 2. Glutamate is the major excitatory and Gamma-aminobutyric acid (GABA) the major inhibitory neurotransmitter in the brain.Aim & MethodsWe aimed to measure neurotransmitter concentration in the pregenual ACC, in stool consistency subgroups with IBS by using quantitative neurotransmitter Magnetic Resonance Spectroscopy (qMRS)Seven patients with IBS-mixed (6 women) and five patients with IBS -diarrhea (4 women) according to Rome 3 were included. Mean age was 34.2 years (SD 5.3) with no significant difference between subgroups. Patients completed symptom severity score (IBS-SSS). Quantitative MRS was measured in a 3T MRI scanner. A water-suppressed MEGA-PRESS sequence (TR 2.0 s, TE 68 ms) was used with the editing pulses placed at 1.90 ppm (‘ON-dynamics’) and at 7.46 ppm (‘OFF-dynamics’) with a voxel (3x3x3 cm3) placed in the pACC. Each MEGA-PRESS measurement resulted in a sequence of 40 OFF- and ON-dynamics, where each was computed by 8 phase cycles. Directly after each water-suppressed MEGA-PRESS measurement, a shorter 2-dynamic unsuppressed water MEGA-PRESS measurement was performed within the same voxel, which was used to obtain the concentrations in physically well-defined units of [mM]. The GABA concentrations were computed by averaging the difference spectra obtained by subtracting each OFF-dynamic from subsequent ON-dynamic and using LCModel (Version 6.3) for the final quantification. The Glutamate concentrations were obtained by only averaging the OFF-dynamics, which were not affected by the editing pulses. Additionally, all dynamics were phase and frequency corrected prior to the averaging. For group comparison unpaired T-tests were used.ResultsPatients had moderate to severe symptoms with IBS-SSS of 367 (SD 79.7). There was no significant difference between IBS subgroups in terms of IBS-SSS. Mean pACC GABA concentration was 1.66 (SD 0.17) mM in IBS-M and 1.65 (SD 0.27) mM in IBS-D. There was no significant difference between groups (p=0.9). Mean pACC Glutamate concentration was 4.54 (0.35) mM in IBS-M and 5.13 (SD 0.64) mM in IBS-D. There was no significant difference between groups, although a trend with p=0.06 was observed.ConclusionFurther qMRS data have to be collected in IBS patients as well as healthy controls to evaluate if IBS subgroups demonstrate alterations in pACC glutamate and GABA concentrations
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