| 1. |
- Wang, Zhaoming, et al.
(författare)
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Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
- 2014
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
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| 2. |
- Weinstein, John N., et al.
(författare)
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The cancer genome atlas pan-cancer analysis project
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:10, s. 1113-1120
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Forskningsöversikt (refereegranskat)abstract
- The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
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| 3. |
- Cai, Xiaoping, et al.
(författare)
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Fabrication of Highly Porous CuAl Intermetallic by Thermal Explosion Using NaCl Space Holder
- 2018
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Ingår i: JOM. - : The Minerals, Metals, and Materials Society. - 1047-4838 .- 1543-1851. ; 70:10, s. 2173-2178
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Tidskriftsartikel (refereegranskat)abstract
- A high-porosity CuAl-based intermetallic compound with composition Cu-50 at.% Al has been successfully prepared by thermal explosion (TE) using NaCl as space holder. The results showed that the NaCl particles were completely removed from the green compact by water leaching. The temperature of the specimen during the TE and the evolution of the porous microstructure were investigated. The TE was ignited at 560°C, and the specimen temperature increased to 775°C in 3 s, resulting in formation of intermetallic CuAl and CuAl2 phases in the final product. A porous CuAl-based intermetallic compound with up to 62 vol.% open porosity was produced when adding 60 vol.% NaCl. The compound exhibited a bimodal pore size structure, including large pores (200 μm to 300 μm) that replicated the NaCl particles and small pores (5 μm to 10 μm) interspersed in the pore walls. Moreover, the large pores were interconnected by channels and formed an open CuAl-based intermetallic cellular structure, having great potential for use in heat exchange and filtration applications.
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| 4. |
- Cai, Xiaoping, et al.
(författare)
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Oxidation Resistance of Highly Porous Fe-Al Foams Prepared by Thermal Explosion
- 2018
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Ingår i: Metallurgical and Materials Transactions. A. - : Springer. - 1073-5623 .- 1543-1940. ; 49A:8, s. 3683-3691
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Tidskriftsartikel (refereegranskat)abstract
- Open-cell Fe-Al intermetallic foams were successfully prepared by a simple and energy-saving thermal explosion (TE) process. The effects of the Fe/Al molar ratio (Fe-(40–50) at. pct Al) and thermal treatment temperature on the TE temperature profile, phase composition, pore characteristics, and oxidation resistance of the prepared foams were investigated. The results showed that the Al content significantly influenced the ignition (Tig) and combustion (Tc) temperatures of the TE process; in particular, as the Al content decreased, Tig increased gradually from 623 °C to 636 °C and Tc decreased from 1059 °C to 981 °C. FeAl was identified as the dominant phase in the thermally treated foams. The Fe-Al intermetallic foams displayed an open porosity of 60 vol pct, with pores connected with each other to form an open pore structure. The formation of the pores was attributed to the expansion of interparticle pores in the pressed body during the TE reaction. X-ray photoelectron spectroscopy analysis of the Fe-50Al foam showed that the Al 2p and O 1s binding energies were 74.5 eV and at 531.4 eV, respectively. The formation of a surface alumina layer in the early stages of the oxidation process resulted in the parabolic oxidation rate law, and the Fe-50Al foams exhibited an excellent resistance to oxidation at 650 °C in air. These results suggest that the synthesized Fe-Al foams represent promising materials for applications involving an oxidizing environment and high temperatures.
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| 5. |
- Xiaoping, Cai, et al.
(författare)
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Preparation of Porous NiAl Intermetallic with Controllable Shape and Pore Structure by Rapid Thermal Explosion with Space Holder
- 2021
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Ingår i: Metals and Materials International. - : Springer. - 1598-9623 .- 2005-4149. ; 27:10, s. 4216-4224
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Tidskriftsartikel (refereegranskat)abstract
- Due to the high exothermic characteristic of NiAl during the reaction synthesis process from Ni–Al elemental powders, the NiAl intermetallic melts frequently, and the specimens are difficult to maintain their original shape, which leads to the inhomogeneity of the pore size and morphology. To tackle this problem, porous NiAl intermetallic monolith with controllable shape and pore structure was prepared through thermal explosion (TE) using NaCl as space holder. The TE behavior was recorded, and the effect of the volume fraction of NaCl on the phase composition, macroscopic feature, pore morphology and open porosity were investigated. The results showed that NiAl was the main phase in the products, and the specimen was free from cracking or deforming when NaCl content reached 30 vol%. The interconnected channel and pore windows were formed, and the open porosity was improved greatly to 63% by adding 50 vol% NaCl. The leachable space holder route provides a simple way to control the shape, pore structure and open porosity of the synthesized porous NiAl intermetallic.
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| 6. |
- Abel, Martin, et al.
(författare)
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Collision-induced absorption by supermolecular complexes from a new potential energy and induced dipole surface, suited for calculations up to thousands of kelvin
- 2010
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Ingår i: 20th International Conference on Spectral Line Shapes. - Melville, NY : American Institute of Physics (AIP). - 9780735408456 ; , s. 251-257
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Konferensbidrag (refereegranskat)abstract
- Absorption by pairs of H2 molecules is an important opacity source in the atmospheres of the outer planets, and thus of special astronomical interest. The emission spectra of cool white dwarf stars differ significantly from the expected blackbody spectra, amongst other reasons due to absorption by H2-H2, H2-He, and H2-H collisional complexes in the stellar atmospheres. To model the radiative processes in these atmospheres, which have temperatures of several thousand kelvin, one needs accurate knowledge of the induced dipole (ID) and potential energy surfaces (PES) of such collisional complexes. These come from quantum-chemical calculations with the H2 bonds stretched or compressed far from equilibrium. Laboratory measurements of collision-induced (CI) absorption exist only at much lower temperature. For H2 pairs at room temperature, the calculated spectra of the rototranslational band, the fundamental band, and the first overtone match the experimental data very well. In addition, with the newly obtained IDS it became possible to reproduce the measurements in the far blue wing of the rototranslational spectrum of H2 at 77.5 K, as well as at 300 K. Similarly good agreement between theory and measurement is seen in the fundamental band of molecular deuterium at room temperature. Furthermore, we also show the calculated absorption spectra of H2-He at 600 K and of H2-H2 at 2,000 K, for which there are no experimental data for comparison
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| 7. |
- Beaumont, Robin N, et al.
(författare)
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Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth.
- 2023
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Ingår i: Nature genetics. - 1546-1718 .- 1061-4036. ; 55:11, s. 1807-19
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Tidskriftsartikel (refereegranskat)abstract
- A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n=65,405), maternal (n=61,228) and paternal (n=52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.
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| 8. |
- Chen, Jiguang, et al.
(författare)
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FEA of helmet-head injury protection based on motorcycle accident reconstruction
- 2013
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Ingår i: Proceedings - 2013 5th Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2013. - 9780769549323 ; , s. 570-573
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Konferensbidrag (refereegranskat)abstract
- Head impact usually causes fatalities of riders in motorcycle accidents. The use of helmet can protect head effectively and the study of head injury mechanism is useful in safety helmet design and head injury risk decrease. A real motorcycle-passenger car accident was reconstructed in order to simulate and analyze the motion, impact velocity, impact angle in the collision. In order to study the dynamic response of helmeted head during the accident impact processing, an effective helmet model was constructed and validated. Coupling with the finite element model of human head, the injury mechanism of head and relevant parameters of biomechanics were studied and the protection ability of helmet was analyzed. It was found that the presence of helmet reduces the probility of head injury.
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| 9. |
- Dai, Bing, et al.
(författare)
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A study on throw distance of electric bicycle and cyclist based on accident reconstruction
- 2013
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Ingår i: Proceedings - 2013 5th Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2013. - 9780769549323 ; , s. 135-138
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Konferensbidrag (refereegranskat)abstract
- This paper aims to determine the correlation of the throw distance of cyclist and electric bicycle in traffic accidents with throw vehicle impact speed. A total of 22 vehicle-electric bicycle accidents were sampled from IVAC database, China. The selected accidents were reconstructed by using PC-Crash and Madymo programs. The relationship between throw distance and vehicle impact velocity was analyzed by using logistic regression model The relationship curves were obtained based on the calculated parameters. With increasing of the vehicle impact velocity, an increase of throw distance was observed. When the vehicle impact velocity was above 30km/h, the throw distance of electric bicycle was larger than that of cyclist. By comparing of results from the PC-Crash and MADYMO simulations with observations from in-depth accident investigation, the feasibility of the reconstruction method and the validity of the numerical model were evaluated. This research could provide a basis for further study on the dynamic response and injury prevention of cyclist.
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| 10. |
- Ding, Huaiyi, et al.
(författare)
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Maximizing Integrated Optical and Electrical Properties of a Single ZnO Nanowire through Native Interfacial Doping
- 2014
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Ingår i: Advanced Materials. - : Wiley. - 0935-9648 .- 1521-4095. ; 26:19, s. 3035-3041
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Tidskriftsartikel (refereegranskat)abstract
- A native interfacial doping layer introduced in core-shell type ZnO nanowires by a simple vapor phase re-growth procedure endows the produced nanowires with both excellent electrical and optical performances compared to conventional homogeneous ZnO nanowires. The unique Zn-rich interfacial structure in the core-shell nanowires plays a crucial role in the outstanding performances.
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