| 1. |
|
|
| 2. |
- Kristan, Matej, et al.
(författare)
-
The Ninth Visual Object Tracking VOT2021 Challenge Results
- 2021
-
Ingår i: 2021 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW 2021). - : IEEE COMPUTER SOC. - 9781665401913 ; , s. 2711-2738
-
Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2021 is the ninth annual tracker benchmarking activity organized by the VOT initiative. Results of 71 trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in recent years. The VOT2021 challenge was composed of four sub-challenges focusing on different tracking domains: (i) VOT-ST2021 challenge focused on short-term tracking in RGB, (ii) VOT-RT2021 challenge focused on "real-time" short-term tracking in RGB, (iii) VOT-LT2021 focused on long-term tracking, namely coping with target disappearance and reappearance and (iv) VOT-RGBD2021 challenge focused on long-term tracking in RGB and depth imagery. The VOT-ST2021 dataset was refreshed, while VOT-RGBD2021 introduces a training dataset and sequestered dataset for winner identification. The source code for most of the trackers, the datasets, the evaluation kit and the results along with the source code for most trackers are publicly available at the challenge website(1).
|
|
| 3. |
- Zhao, Sen, et al.
(författare)
-
Expanding the mutation and phenotype spectrum of MYH3-associated skeletal disorders
- 2022
-
Ingår i: NPJ genomic medicine. - : Nature Publishing Group. - 2056-7944. ; 7:1
-
Tidskriftsartikel (refereegranskat)abstract
- Pathogenic variants in MYH3 cause distal arthrogryposis type 2A and type 2B3 as well as contractures, pterygia and spondylocarpotarsal fusion syndromes types 1A and 1B. These disorders are ultra-rare and their natural course and phenotypic variability are not well described. In this study, we summarize the clinical features and genetic findings of 17 patients from 10 unrelated families with vertebral malformations caused by dominant or recessive pathogenic variants in MYH3. Twelve novel pathogenic variants in MYH3 (NM_002470.4) were identified: three of them were de novo or inherited in autosomal dominant way and nine were inherited in autosomal recessive way. The patients had vertebral segmentation anomalies accompanied with variable joint contractures, short stature and dysmorphic facial features. There was a significant phenotypic overlap between dominant and recessive MYH3-associated conditions regarding the degree of short stature as well as the number of vertebral fusions. All monoallelic variants caused significantly decreased SMAD3 phosphorylation, which is consistent with the previously proposed pathogenic mechanism of impaired canonical TGF-β signaling. Most of the biallelic variants were predicted to be protein-truncating, while one missense variant c.4244T>G,p.(Leu1415Arg), which was inherited in an autosomal recessive way, was found to alter the phosphorylation level of p38, suggesting an inhibition of the non-canonical pathway of TGF-β signaling. In conclusion, the identification of 12 novel pathogenic variants and overlapping phenotypes in 17 affected individuals from 10 unrelated families expands the mutation and phenotype spectrum of MYH3-associated skeletal disorders. We show that disturbances of canonical or non-canonical TGF-β signaling pathways are involved in pathogenesis of MYH3-associated skeletal fusion (MASF) syndrome.
|
|
| 4. |
- Gao, Haixiao, et al.
(författare)
-
RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors
- 2007
-
Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 129:5, s. 929-941
-
Tidskriftsartikel (refereegranskat)abstract
- During translation termination, class II release factor RF3 binds to the ribosome to promote rapid dissociation of a class I release factor (RF) in a GTP-dependent manner. We present the crystal structure of E. coli RF3•GDP, which has a three-domain architecture strikingly similar to the structure of EF-Tu•GTP. Biochemical data on RF3 mutants show that a surface region involving domains II and III is important for distinct steps in the action cycle of RF3. Furthermore, we present a cryo-electron microscopy (cryo-EM) structure of the posttermination ribosome bound with RF3 in the GTP form. Our data show that RF3•GTP binding induces large conformational changes in the ribosome, which break the interactions of the class I RF with both the decoding center and the GTPase-associated center of the ribosome, apparently leading to the release of the class I RF.
|
|
| 5. |
- Su, Wenyan, et al.
(författare)
-
13.4 % Efficiency from All-Small-Molecule Organic Solar Cells Based on a Crystalline Donor with Chlorine and Trialkylsilyl Substitutions
- 2021
-
Ingår i: ChemSusChem. - : Wiley. - 1864-5631 .- 1864-564X. ; 14:17, s. 3535-3543
-
Tidskriftsartikel (refereegranskat)abstract
- How to simultaneously achieve both high open-circuit voltage (Voc) and high short-circuit current density (Jsc) is a big challenge for realising high power conversion efficiency (PCE) in all-small-molecule organic solar cells (all-SM OSCs). Herein, a novel small molecule (SM)-donor, namely FYSM−SiCl, with trialkylsilyl and chlorine substitutions was designed and synthesized. Compared to the original SM-donor FYSM−H, FYSM−Si with trialkylsilyl substitution showed a decreased crystallinity and lower highest occupied molecular orbital (HOMO) level, while FYSM−SiCl had an improved crystallinity, more ordered packing arrangement, significantly lower HOMO level, and predominant “face-on” orientation. Matched with a SM-acceptor Y6, the FYSM−SiCl-based all-SM OSCs exhibited both high Voc of 0.85 V and high Jsc of 23.7 mA cm−2, which is rare for all-SM OSCs and could be attributed to the low HOMO level of FYSM−SiCl donor and the delicate balance between high crystallinity and suitable blend morphology. As a result, FYSM−SiCl achieved a high PCE of 13.4 % in all-SM OSCs, which was much higher than those of the FYSM−H- (10.9 %) and FYSM−Si-based devices (12.2 %). This work demonstrated a promising method for the design of efficient SM-donors by a side-chain engineering strategy via the introduction of trialkylsilyl and chlorine substitutions.
|
|
| 6. |
- Wang, Zhenhua, et al.
(författare)
-
A numerical study of radiative heat transfer in a cylindrical furnace by using finite volume method
- 2016
-
Ingår i: Heat Transfer in Energy Systems; Thermophysical Properties; Theory and Fundamentals in Heat Transfer; Nanoscale Thermal Transport; Heat Transfer in Equipment; Heat Transfer in Fire and Combustion; Transport Processes in Fuel Cells and Heat Pipes; Boiling and Condensation in Macro, Micro and Nanosystems. - 9780791850329 ; 1
-
Konferensbidrag (refereegranskat)abstract
- In designing industrial cylindrical furnaces, it is important to predict the radiative heat flux on the wall with high accuracy. In this study, we consider CO2 and H2O which have strong absorption in the infrared range. The absorption coefficients of the gases are calculated by using the statistical narrow band (SNB) model. The spectrum is divided into 15 bands to cover all the absorption regions of the two non-gray gases. The radiative transfer equation is solved by the finite volume method (FVM) in cylindrical coordinates. To make the FVM more accurate, we discretize the solid angle into 80 directions with the S8 approximation which is found to be both efficient and less time consuming. Based on the existing species and temperature fields, which were modeled by the FLUENT commercial code, the radiative heat transfer in a cylinder combustor is simulated by an in-house code. The results show that the radiative heat flux plays a dominant part of the heat flux to the wall. Meanwhile, when the gas is considered as nongray, the computational time is very huge. Therefore, a parallel algorithm is also applied to speed up the computing process.
|
|
| 7. |
- Wang, Zhenhua, et al.
(författare)
-
Numerical analysis of radiative heat transfer in an inhomogeneous and non-isothermal combustion system considering H2O/CO2/CO and soot
- 2017
-
Ingår i: International Journal of Numerical Methods for Heat and Fluid Flow. - 0961-5539. ; 27:9, s. 1967-1985
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose - H2O, CO2 and CO are three main species in combustion systems which have high volume fractions. In addition, soot has strong absorption in the infrared band. Thus, H2O, CO2, CO and soot may take important roles in radiative heat transfer. To provide calculations with high accuracy, all of the participating media should be considered non-gray media. Thus, the purpose of this paper is to study the effect of non-gray participating gases and soot on radiative heat transfer in an inhomogeneous and non-isothermal system. Design/methodology/approach - To solve the radiative heat transfer, the fluid flow as well as the pressure, temperature and species distributions were first computed by FLUENT. The radiative properties of the participating media are calculated by the Statistical Narrow Band correlated Kdistribution (SNBCK), which is based on the database of EM2C. The calculation of soot properties is based on the Mie scattering theory and Rayleigh theory. The radiative heat transfer is calculated by the discrete ordinate method (DOM). Findings - Using SNBCK to calculate the radiative properties and DOM to calculate the radiative heat transfer, the influence of H2O, CO2, CO and soot on radiation heat flux to the wall in combustion system was studied. The results show that the global contribution of CO to the radiation heat flux on the wall in the kerosene furnace was about 2 per cent, but that it can reach up to 15 per cent in a solid fuel gasifier. The global contribution of soot to the radiation heat flux on the wall was 32 per cent. However, the scattering of soot has a tiny influence on radiation heat flux to the wall. Originality/value - This is the first time H2O, CO2, CO and the scattering of soot were all considered simultaneously to study the radiation heat flux in combustion systems.
|
|
| 8. |
- Yang, Zhen, et al.
(författare)
-
Elevated Serum Chemokine CXC Ligand 5 Levels Are Associated with Hypercholesterolemia But Not a Worsening of Insulin Resistance in Chinese People.
- 2010
-
Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 95, s. 3926-3932
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: Recent study showed high chemokine CXC ligand 5 (CXCL5) is thought to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between serum CXCL5 level and metabolic phenotypes is scarce. Here we sought to evaluate serum CXCL5 distribution and its association with metabolic phenotypes among middle-aged and older Chinese. Research Design and Methods: We evaluated serum CXCL5 in a cross-sectional sample of 3225 Chinese aged from 50 to 88 yr in a Shanghai downtown district by ELISA. Glucose, insulin, lipid profile, inflammatory marker, and adipokine were also measured. Results: The crude mean of serum CXCL5 concentrations were 1493.31 pg/ml for men and 2059.42 pg/ml for women (P < 0.001), respectively. After multiple adjustment, the odds ratios were substantially higher for hypercholesterolemia (odds ratio 3.26, 95% confidence interval 2.36-4.51) in the highest CXCL5 quartile compared with those in the lowest quartile. These associations remained significant after further adjustment for body mass index, body fat, inflammatory marker, and adipokine. However, serum resistin CXCL5 was not associated with body mass index, percent body fat, fasting glucose, insulin levels, and homeostasis model assessment index-insulin resistance (r = 0.01, 0.01, 0.01, 0.04, and 0.03, respectively; all P > 0.05). Conclusions: Elevated circulating CXCL5 concentrations were associated with higher risk of hypercholesterolemia in middle-aged and elderly Chinese independent of obesity, inflammation, adipokines, and other risk factors but not insulin resistance.
|
|
| 9. |
- Zhao, Zhihong, et al.
(författare)
-
Impact of stress on solute transport in a fracture network : A comparison study
- 2013
-
Ingår i: Journal of Rock Mechanics and Geotechnical Engineering. - : Chinese Academy of Sciences. - 1674-7755. ; 5:2, s. 110-123
-
Tidskriftsartikel (refereegranskat)abstract
- This paper compares numerical modeling of the effect of stress on solute transport (advection and matrix diffusion) in fractured rocks in which fracture apertures are correlated with fracture lengths. It is mainly motivated by the performance and safety assessments of underground radioactive waste repositories. Five research teams used different approaches to model stress/deformation, flow and transport processes, based on either discrete fracture network or equivalent continuum models. The simulation results derived by various teams generally demonstrated that rock stresses could significantly influence solute transport processes through stress-induced changes in fracture apertures and associated changes in permeability. Reasonably good agreement was achieved regarding advection and matrix diffusion given the same fracture network, while some observed discrepancies could be explained by different mechanical or transport modeling approaches.
|
|
| 10. |
|
|
