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- Chappell, Stacie, et al.
(författare)
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A required GVV ethics course : Conscripting ethical conversations
- 2011
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Ingår i: Journal of Business Ethics Education. - 1649-5195 .- 2044-4559. ; 8:1, s. 308-319
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Tidskriftsartikel (refereegranskat)abstract
- Business schools around the globe are seeking effective ways of incorporating business ethics into their programs (Melé 2008, Swanson 2004). Indications from both the market and accrediting bodies suggest best-practice programs will include ethics education. However, the debate continues as to whether meaningful learning is best achieved through stand-alone ethics experiences or via an integrated theme across the program of study (Tesfayohannes & Driscoll 2010, Wilhelm 2005). While many examples of required ethics-experiences can be found, to date, there is only one business school that we are aware of that has implemented a required full-term post-graduate ethics course based on the Giving Voice To Values (GVV) (Gentile 2008) philosophy and content. The purpose of this article is to share the tacit knowledge gained in the authors' experience of implementing such a course at the University of Western Australia's Business School.
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- Chappell, Stacie, et al.
(författare)
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Sustaining voices : Applying giving voice to values to sustainability issues
- 2013
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Ingår i: Journal of Business Ethics Education. - : Philosophy Documentation Center. - 1649-5195 .- 2044-4559. ; 10:1, s. 211-230
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Tidskriftsartikel (refereegranskat)abstract
- We apply an action-oriented approach to business ethics education, Giving Voice to Values (GVV), to the topic of sustainability. The increasingly problematic impact of unsustainable economic activity is demanding actionable responses from business. However, traditional business ethics education has focussed on awareness and decision-making and neglected action-oriented methods. The GVV curriculum offers an applied and process-driven ethics approach that complements more analytical ethics pedagogies. Because of its focus on action and expressing personal values, GVV can be thought of as largely applicable to the micro-level of interpersonal interactions. This paper illustrates GVV's potential for much broader application by presenting two caselettes spanning the micro-level of workplace refurbishment to the global-level of the mass dumping of electronic waste. Ways of crafting conversations around these sustainability issues are presented and implications of the GVV approach for both the teaching and practice of sustainability ethics are discussed.
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- Hillier, Ladeana W, et al.
(författare)
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Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
- 2004
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 432:7018, s. 695-716
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Tidskriftsartikel (refereegranskat)abstract
- We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.
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- Nakayasu, Ernesto S, et al.
(författare)
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Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity
- 2023
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Ingår i: Cell Reports Medicine. - 2666-3791. ; 4:7
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Tidskriftsartikel (refereegranskat)abstract
- Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study to identify biomarkers predictive of T1D development. Untargeted proteomics of 2,252 samples from 184 individuals identify 376 regulated proteins, showing alteration of complement, inflammatory signaling, and metabolic proteins even prior to autoimmunity onset. Extracellular matrix and antigen presentation proteins are differentially regulated in individuals who progress to T1D vs. those that remain in autoimmunity. Targeted proteomics measurements of 167 proteins in 6,426 samples from 990 individuals validate 83 biomarkers. A machine learning analysis predicts if individuals would remain in autoimmunity or develop T1D 6 months before autoantibody appearance, with areas under receiver operating characteristic curves of 0.871 and 0.918, respectively. Our study identifies and validates biomarkers, highlighting pathways affected during T1D development.
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