| 1. |
- Jia, Shi, et al.
(author)
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2 x 300 Gbit/s Line Rate PS-64QAM-OFDM THz Photonic-Wireless Transmission
- 2020
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In: Journal of Lightwave Technology. - : Institute of Electrical and Electronics Engineers (IEEE). - 0733-8724 .- 1558-2213. ; 38:17, s. 4715-4721
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Journal article (peer-reviewed)abstract
- The proliferation of wireless broadband services have significantly raised the demand for high data rates. Due to the limited bandwidth of radio frequency (RF) bands that are currently in use for communication purposes, the choice of the 'Terahertz (THz) frequency region' (0.3-10 THz) is getting favored thanks to its merits of bringing together wireless and optical communications with photonics technologies. We report on an experimental demonstration of a hybrid THz photonic-wireless transmission based on a THz orthogonal polarization dual-antenna scheme. Probabilistic shaped 64-ary quadrature amplitude modulation based orthogonal frequency division multiplexing (64QAM-OFDM) modulation format is used to realize high transmission rate. A potential total system throughput of 612.65 Gbit/s (around 2 x 300 Gbit/s line rate) with an average net spectral efficiency of 4.445 bit/s/Hz per antenna is successfully achieved.
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| 2. |
- Liu, Fang, et al.
(author)
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Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor B signaling pathway
- 2017
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In: Oncotarget. - : IMPACT JOURNALS LLC. - 1949-2553. ; 8:13, s. 22059-22075
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Journal article (peer-reviewed)abstract
- Gastric cancer is one of the most common cancers in Asian countries. Searching for reliable biomarkers involving the development of gastric cancer is important for clinical practice. Quantitative proteomics has become an important method contributed to the discovery of novel diagnostic or therapeutic targets for the management of cancer. Here, we identified differently expressed proteins in gastric cancer and normal gastric tissues by using the high resolution mass spectrometer. Among the total of 2280 identified proteins, 87 were differentially expressed between gastric cancer and normal gastric tissues. Notably, several significant proteins are in the PDGF-B signaling pathway, including peroxiredoxin5 (PRDX5), S100A6, calreticulin (CALR) and cathepsin D (CTSD), which were validated by western blot. Furthermore, upstream regulators including PDGF-B, PDGFR-beta, Akt, eIF4E and p70s6K were found significantly increased in the gastric cancer tissues. In addition, silencing of PRDX5 and PDGF-B suppressed the proliferation of gastric cancer cells in vitro. The administration of exogenous PDGF-BB recovered the reduced expression of PDGF-B signaling pathway in PDGF-B knockdown cells. Taken together, our findings suggested that PDGF-B signaling pathway plays an important role in the regulation of gastric cancer proliferation and the inhibition of this pathway may be a potential approach for treatment of gastric cancer.
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| 3. |
- Liu, Kexin, et al.
(author)
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100 Gbit/s THz Photonic Wireless Transmission in the 350-GHz Band With Extended Reach
- 2018
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In: IEEE Photonics Technology Letters. - : Institute of Electrical and Electronics Engineers (IEEE). - 1041-1135 .- 1941-0174. ; 30:11, s. 1064-1067
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Journal article (peer-reviewed)abstract
- In this letter, we experimentally demonstrate terahertz (THz) photonic wireless transmission of high-speed quadrature-phase-shift-keying (QPSK) and 16 quadrature amplitude modulation (16-QAM) signals in the 350-GHz band, with an effort to extend the wireless reach of ultrafast 100 Gbit/s. In the experiment, a narrowband unitraveling-carrier photodiode (UTC-PD) is used for heterodyne generation of THz communication signals, which is transparent to optical modulation formats. Experimental results show that 30 GBd/s QPSK (60 Gbit/s) and 25 GBd/s 16-QAM signals (100 Gbit/s) are successfully transmitted over a 350-GHz wireless link with an extended distance of 2 m. This enhancement is enabled by combining the techniques of employing cutting-edge narrowband UTC-PD as the photomixing THz emitter, spectrally efficient modulation format and advanced digital signal processing algorithms. The achievement makes 100 Gbit/s THz wireless communication systems promising for future smart wireless services.
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| 4. |
- Liu, Kexin, et al.
(author)
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Enhanced Accessibility of 350 GHz 100 Gbit/s 16-QAM Photonic Wireless Link
- 2018
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In: Proceedings 11th UK-Europe-China Workshop on Millimetre-Waves and Terahertz Technologies (UCMMT) Vol 1. - : Institute of Electrical and Electronics Engineers (IEEE).
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Conference paper (peer-reviewed)abstract
- We experimentally demonstrate an ultrafast terahertz (THz) photonic wireless communication link in the 350 GHz band with up to 100 Gbit/s data rate, with an emphasis on extending its wireless reach. By combining the techniques of using a cutting-edge narrow-band uni-traveling-carrier photodiode (UTC-PD) as the THz photo-mixing emitter, spectrally efficient modulation formats and advanced digital signal processing (DSP) algorithms, we successfully transmit 25 GBaud/s 16-quadrature amplitude modulation (16-QAM) signals (overall 100 Gbit/s data rate) over a 350 GHz wireless link with an extended distance of 2 m. This achievement pushes the accessibility of ultrafast 100 Gbit/s wireless communication beyond the state-of-the-art, and makes 100 Gbit/s ultrafast THz wireless communication systems promising for future smart high speed wireless access services.
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| 5. |
- Qiao, Mengyao, et al.
(author)
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60 Gbit/s PAM-4 wireless transmission in the 310 GHz band with nonlinearity tolerant signal processing
- 2021
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In: Optics Communications. - : Elsevier BV. - 0030-4018 .- 1873-0310. ; 492
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Journal article (peer-reviewed)abstract
- We experimentally demonstrate a terahertz (THz) photonic wireless transmission system in the 310 GHz band with four-level pulse amplitude modulation (PAM-4) signals. A zero-bias diode is used as a simple direct detection receiver, which is cost-effective compared to a conventional coherent receiver. Moreover, we comprehensively investigate the system performance by applying linear and nonlinear equalization schemes. The experimental results show that Volterra nonlinear filtering can significantly improve the system capacity by around 90%, and transmissions of up to 60 Gbit/s PAM-4 signals over a 3 m wireless link are successfully achieved. The advantageous features of this make it promising for high-speed THz wireless communications.
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| 6. |
- Shi, Xiaodan, et al.
(author)
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MetaTraj : Meta-Learning for Cross-Scene Cross-Object Trajectory Prediction
- 2023
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In: IEEE transactions on intelligent transportation systems (Print). - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1524-9050 .- 1558-0016.
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Journal article (peer-reviewed)abstract
- Long-term pedestrian trajectory prediction in crowds is highly valuable for safety driving and social robot navigation. The recent research of trajectory prediction usually focuses on solving the problems of modeling social interactions, physical constraints and multi-modality of futures without considering the generalization of prediction models to other scenes and objects, which is critical for real-world applications. In this paper, we propose a general framework that makes trajectory prediction models able to transfer well across unseen scenes and objects by quickly learning the prior information of trajectories. The trajectory sequences are closely related to the circumstance setting (e.g. exits, roads, buildings, entries etc.) and the objects (e.g. pedestrians, bicycles, vehicles etc.). We argue that those trajectory information varying across scenes and objects makes a trained prediction model not perform well over unseen target data. To address it, we introduce MetaTraj that contains carefully designed sub-tasks and meta-tasks to learn prior information of trajectories related to scenes and objects, which then contributes to accurate long-term future prediction. Both sub-tasks and meta-tasks are generated from trajectory sequences effortlessly and can be easily integrated into many prediction models. Extensive experiments over several trajectory prediction benchmarks demonstrate that MetaTraj can be applied to multiple prediction models and enables them generalize well to unseen scenes and objects.
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| 7. |
- Wang, Shiwei, et al.
(author)
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26.8-m THz wireless transmission of probabilistic shaping 16-QAM-OFDM signals
- 2020
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In: APL Photonics.. - : AIP Publishing. - 2378-0967. ; 5:5
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Journal article (peer-reviewed)abstract
- Recently, remarkable efforts have been made in developing wireless communication systems at ultrahigh data rates, with radio frequency (RF) carriers in the millimeter wave (30-300 GHz) and/or in the terahertz (THz, >300 GHz) bands. Converged technologies combining both the electronics and the photonics show great potential to provide feasible solutions with superior performance compared to conventional RF technologies. However, technical challenges remain to be overcome in order to support high data rates with considerably feasible wireless distances for practical applications, particularly in the THz region. In this work, we present an experimental demonstration of a single-channel THz radio-over-fiber (RoF) system operating at 350 GHz, achieving beyond 100 Gbit/s data rate over a 10-km fiber plus a >20-m wireless link, without using any THz amplifiers. This achievement is enabled by using an orthogonal frequency division multiplexing signal with a probabilistic-shaped 16-ary quadrature amplitude modulation format, a pair of highly directive Cassegrain antennas, and advanced digital signal processing techniques. This work pushes the THz RoF technology one step closer to ultrahigh-speed indoor wireless applications and serves as an essential segment of the converged fiber-wireless access networks in the beyond 5G era.
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| 8. |
- Wei, Xiaodan, et al.
(author)
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PDLIM5 identified by label-free quantitative proteomics as a potential novel biomarker of papillary thyroid carcinoma
- 2018
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In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 499:2, s. 338-344
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Journal article (peer-reviewed)abstract
- In order to better understand the mechanisms underlying the development of papillary thyroid carcinoma (PTC), and to identify new potential biomarkers, high-resolution label-free mass spectrometry was performed on PTC tissues and adjacent normal thyroid tissues from six patients. In this process, 2788 proteins were identified, out of which 49 proteins presented significant differences between PTC tissues and adjacent normal thyroid tissues. Gene ontology revealed that the majority of these proteins are involved in the catalytic activity and binding. We selected three proteins with differential expressions: PDZ and LIM domain 5 (PDLIM5), PDLIM1 and ALDH1A1; Protein expressions were further verified by RT-PCR and western blot. Among these, expression of PDLIM5 and PDLIM1 was up-regulated, while that of ALDH1A1 was down-regulated in PTC tissues. Next, we confirmed their expression through quantitative dot blot (QDB) technique. We found that knockdown of PDLIM5 expression in the B-CPAP cell line could inhibit the migration, invasion and proliferation of PTC cells. In addition, PDLIM5 knockdown reduced Ras and Phospho-ERK1/2 expression. Thus, we suggested that PDLIM5 promotes PTC via activation of the Ras-ERK pathway. Our research provides new molecular insight into the function of PDLIM5, which may assist in studying the mechanism of PTC. In addition, PDLIM5 could be further explored as a potential candidate for PTC treatment.
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| 9. |
- Wei, Xiaodan, et al.
(author)
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The Number of Stenotic Intracranial Arteries Is Independently Associated with Ischemic Stroke Severity
- 2016
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:9
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Journal article (peer-reviewed)abstract
- Background The severity of ischemic stroke symptoms varies among patients and is a critical determinant of patient outcome. To date, the association between the number of stenotic intracranial arteries and stroke severity remains unclear. Aims We aimed to investigate the association between the number of stenotic major intracranial arteries (NSMIA) and ischemic stroke severity, as well as the degree of stenosis and common stroke risk factors. Methods We performed a retrospective analysis of patients with digital subtraction angiography (DSA)-confirmed ischemic stroke. Clinical stroke severity was measured using the National Institutes of Health Stroke Scale (NIHSS). The number of stenotic vessels was counted from the internal carotid arteries and vertebral arteries, bilaterally. Results Eighty three patients were recruited from a single center and included in the study. NSMIA was significantly correlated with stroke severity (Pearson Correlation Coefficient = 0.485, P < 0.001), but not with the degree of stenosis (Pearson Correlation Coefficient = 0.01, P = 0.90). Multivariate regression analysis revealed that NSMIA was significantly associated with the NIHSS score after adjusting for stroke risk factors. The adjusted odds ratio (per lateral) was 2.092 (95% CI, 0.865 to 3.308, P = 0.001). The degree of stenosis was also significantly associated with the NIHSS score after adjusting for common risk factors. The odds ratio (per 10%) was 0.712 (95% CI, 0.202 to 1.223, P = 0.007). Conclusions The number of stenotic intracranial major arteries is associated with the severity of ischemic stroke independent of the degree of stenosis and other stroke risk factors. To the best of our knowledge, this has not been previosuly studied in great detail using DSA. Our data highlight the importance of examining all major arteries in stroke patients.
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| 10. |
- Zhang, Yuan, et al.
(author)
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Quantitative Proteomics of TRAMP Mice Combined with Bioinformatics Analysis Reveals That PDGF-B Regulatory Network Plays a Key Role in Prostate Cancer Progression
- 2018
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In: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 17:7, s. 2401-2411
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Journal article (peer-reviewed)abstract
- Transgenic adenocarcinoma of the mouse prostate (TRAMP) mice is a widely used transgenic animal model of prostate cancer (PCa). We performed a label-free quantitative proteomics analysis combined with a bioinformatics analysis on the entire prostate protein extraction from TRAMP mice and compared it with WT littermates. From 2379 total identified proteins, we presented a modest mice prostate reference proteome containing 919 proteins. 61 proteins presented a significant expression difference between two groups. The integrative bioinformatics analysis predicted the overexpression of platelet-derived growth factor B (PDGF-B) in tumor tissues and supports the hypothesis of the PDGF-B signaling network as a key upstream regulator in PCa progression. Furthermore, we demonstrated that Crenolanib, a novel PDGF receptor inhibitor, inhibited PCa cell proliferation in a dose-dependent manner. Finally, we revealed the importance of PDGF-B regulatory network in PCa progression, which will assist us in understanding the role and mechanisms of PDGF-B in promoting cancer growth and provide valuable knowledge for future research on anti-PDGF therapy.
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