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| 2. |
- Andersen, Christen Lykkegaard, et al.
(författare)
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Circulating YKL-40 in patients with essential thrombocythemia and polycythemia vera treated with the novel histone deacetylase inhibitor vorinostat
- 2014
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Ingår i: Leukemia Research. - : Elsevier. - 0145-2126 .- 1873-5835. ; 38:7, s. 816-821
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Tidskriftsartikel (refereegranskat)abstract
- YKL-40 regulates vascular endothelial growth factors and induces tumor proliferation. We investigated YKL-40 before and after treatment with vorinostat in 31 polycythemia vera (PV) and 16 essential thrombocythemia (ET) patients. Baseline PV patient levels were 2 times higher than in healthy controls (P<0.0001) and 1.7 times higher than in ET (P = 0.02). A significant correlation between YKL-40 at baseline and neutrophils, CRP, LDH, JAK2V617F and platelets in PV patients was observed, as well as a significantly greater reduction of YKL-40 levels in PV patients responding to therapy. YKL-40 might be a novel marker of disease burden and progression in myeloproliferative neoplasms.
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| 3. |
- Füchtbauer, Anders Foller, 1984, et al.
(författare)
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Interbase FRET in RNA: from A to Z
- 2019
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 47:19, s. 9990-9997
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Tidskriftsartikel (refereegranskat)abstract
- Interbase FRET can reveal highly detailed information about distance, orientation and dynamics in nucleic acids, complementing the existing structure and dynamics techniques. We here report the first RNA base analogue FRET pair, consisting of the donor tC(O) and the non-emissive acceptor tC(nitro). The acceptor ribonucleoside is here synthesised and incorporated into RNA for the first time. This FRET pair accurately reports the average structure of A-form RNA, and its utility for probing RNA structural changes is demonstrated by monitoring the transition from A- to Z-form RNA. Finally, the measured FRET data were compared with theoretical FRET patterns obtained from two previously reported Z-RNA PDB structures, to shed new light on this elusive RNA conformation.
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| 4. |
- Gosselin, Stéphane, et al.
(författare)
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Fixed and Mobile Convergence: Needs and Solutions
- 2014
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Konferensbidrag (refereegranskat)abstract
- The drivers of Fixed and Mobile Convergence (FMC) are discussed. A reference framework for FMC proposed by European project COMBO is then presented. Some use cases of FMC are described, showing the needs for mutualization and convergence of fixed and mobile broadband networks. Five network scenarios providing technical solutions to FMC use cases are proposed. They target an optimal and seamless quality of experience for the end user together with an optimized network infrastructure ensuring increased performance, flexibility, reduced cost and reduced energy consumption.
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| 5. |
- Jonsson, Erik, et al.
(författare)
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Magmatic origin of giant 'Kiruna-type' apatite-iron-oxide ores in Central Sweden
- 2013
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 3, s. 1644-
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Tidskriftsartikel (refereegranskat)abstract
- Iron is the most important metal for modern industry and Sweden is by far the largest iron-producer in Europe, yet the genesis of Sweden's main iron-source, the 'Kiruna-type' apatite-iron-oxide ores, remains enigmatic. We show that magnetites from the largest central Swedish 'Kiruna-type' deposit at Grangesberg have delta O-18 values between -0.4 and +3.7%, while the 1.90-1.88 Ga meta-volcanic host rocks have d18O values between +4.9 and +9%. Over 90% of the magnetite data are consistent with direct precipitation from intermediate to felsic magmas or magmatic fluids at high-temperature (delta O-18(mgt). > +0.9 parts per thousand, i.e. ortho-magmatic). A smaller group of magnetites (delta O-18(mgt) <= +0.9 parts per thousand), in turn, equilibrated with high-delta O-18, likely meteoric, hydrothermal fluids at low temperatures. The central Swedish 'Kiruna-type' ores thus formed dominantly through magmatic iron-oxide precipitation within a larger volcanic superstructure, while local hydrothermal activity resulted from low-temperature fluid circulation in the shallower parts of this system.
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| 7. |
- Lupi, Matteo, et al.
(författare)
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Regional earthquakes followed by delayed ground uplifts at Campi Flegrei Caldera, Italy : Arguments for a causal link
- 2017
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Ingår i: Earth and Planetary Science Letters. - : Elsevier BV. - 0012-821X .- 1385-013X. ; 474, s. 436-446
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Tidskriftsartikel (refereegranskat)abstract
- Earthquake-triggered volcanic activity promoted by dynamic and static stresses are considered rare and difficult-to-capture geological processes. Calderas are ideal natural laboratories to investigate earthquake volcano interactions due to their sensitivity to incoming seismic energy. The Campi Flegrei caldera, Italy, is one of the most monitored volcanic systems worldwide. We compare ground elevation time series at Campi Flegrei with earthquake catalogues showing that uplift events at Campi Flegrei are associated with large regional earthquakes. Such association is supported by (yet non-definitive) binomial tests. Over a 70-year time window we identify 14 uplift events, 12 of them were preceded by an earthquake, and for 8 of them the earthquake-to-uplift timespan ranges from immediate responses to 1.2 yr. Such variability in the response delay may be due to the preparedness of the system with faster responses probably occurring in periods during which the Campi Flegrei system was already in a critical state. To investigate the process that may be responsible for the proposed association we simulate the propagation of elastic waves and show that passing body waves impose high dynamic strains at the roof of the magmatic reservoir of the Campi Flegrei at about 7 km depth. This may promote a short-lived embrittlement of the magma reservoir's carapace otherwise marked by a ductile behaviour. Such failure allows magma and exsolved volatiles to be released from the magmatic reservoir. The fluids, namely exsolved volatiles and/or melts, ascend through a nominally plastic zone above the magmatic reservoir. This mechanism and the associated inherent uncertainties require further investigations but the new concept already implies that geological processes triggered by passing seismic waves may become apparent several months after passage of the seismic waves. (C) 2017 Elsevier B.V. All rights reserved.
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| 10. |
- Sahlström, Fredrik, et al.
(författare)
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Interaction between high-temperature magmatic fluids and limestone explains 'Bastnäs-type' REE deposits in central Sweden
- 2019
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- The presently increasing demand for rare earth elements (REE), particularly in high-tech and "green energy" applications, has led to global interest in the distribution, origins and formation conditions of REE deposits. The World's first hard-rock REE sources, the polymetallic deposits of Bastnasfaltet in Bergslagen, central Sweden, were also the place of the original discovery of several REE and many of their host minerals. Similar deposits with high concentrations of REE occur along a >100 km corridor in the region and they share a number of geological and mineralogical features; all comprising Palaeoproterozoic, skarn-hosted magnetite-REE mineralisation of ambiguous origin. Here we report oxygen isotope data for magnetite and quartz, and oxygen and carbon isotope data for carbonates from ten of these classic deposits, to model and assess their mode of origin. Combined with existing geological observations, the isotope results support an origin in a c. 1.9 Ga shallow-marine back-arc, sub-seafloor setting, where felsic magmatic-sourced, high-temperature fluids reacted with pre-existing limestone interlayers, leading to localised skarn formation and magnetite-REE-mineral precipitation. These findings help us to better understand the geological processes that have produced economic REE mineralisation and may assist future exploration for these critical commodities.
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