| 1. |
- Bodin, Johanna, et al.
(författare)
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Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice
- 2015
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Ingår i: Toxicology Reports. - : Elsevier BV. - 2214-7500. ; 2, s. 99-110
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Tidskriftsartikel (refereegranskat)abstract
- Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic beta-cells due to a genetic predisposition and can be triggered by environmental factors. We have previously shown that bisphenol A (BPA) accelerates the spontaneous development of diabetes in non-obese diabetic (NOD) mice. Here, we hypothesized that oral exposure to a mixture of the endocrine disruptors BPA and phthalates, relevant for human exposure, would accelerate diabetes development compared to BPA alone. NOD mice were exposed to BPA (1 mg/l), a mixture of phthalates (DEHP 1 mg/l, DBP 0.2 mg/l, BBP 10 mg/l and DiBP 20 mg/l) or a combination of BPA and the phthalate mixture through drinking water from conception and throughout life. Previous observations that BPA exposure increased the prevalence of diabetes and insulitis and decreased the number of tissue resident macrophages in pancreas were confirmed, and extended by demonstrating that BPA exposure also impaired the phagocytic activity of peritoneal macrophages. None of these effects were observed after phthalate exposure alone. The phthalate exposure in combination with BPA seemed to dampen the BPA effects on macrophage number and function as well as diabetes development, but not insulitis development. Exposure to BPA alone or in combination with phthalates decreased cytokine release (TNFα, IL-6, IL-10, IFNγ, IL-4) from in vitro stimulated splenocytes and lymph node cells, indicating systemic changes in immune function. In conclusion, exposure to BPA, but not to phthalates or mixed exposure to BPA and phthalates, accelerated diabetes development in NOD mice, apparently in part via systemic immune alterations including decreased macrophage function.
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| 2. |
- Fagevik Olsén, Monika, 1964, et al.
(författare)
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Self-administered tests as a screening procedure for pregnancy-related pelvic girdle pain
- 2009
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Ingår i: EUROPEAN SPINE JOURNAL. - : Springer Science and Business Media LLC. - 0940-6719 .- 1432-0932. ; 18:8, s. 1121-1129
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate sensitivity and specificity of self-administrated tests aimed at pain provocation of posterior and/or anterior pelvis pain and to investigate pain intensity during and after palpation of the symphysis. A total of 175 women participated in the study, 100 pregnant women with and 25 pregnant women without lumbopelvic back pain and 50 non-pregnant women. Standard pain provocation tests were compared with self assessed tests. All women were asked to estimate pain during and after palpation of the symphysis. For posterior pelvic pain, the self-test of P4 and Bridging test had the highest sensitivity of 0.90 versus 0.97 and specificity of 0.92 and 0.87. Highest sensitivity for self-test for anterior pelvic pain was pulling a mat 0.85. Palpation of symphysis was painful and persistency of pain was the longest among women who fulfilled the criteria for symphyseal pain. There were overall significant differences between the groups concerning intensity and persistency of pain (P andlt; 0.001). Our results indicate that pregnant women can perform a screening by provocation of posterior pelvic pain by self-tests with the new P4 self-test and the Bridging test. Palpation of the symphysis is painful and should only be used as a complement to history taking, pain drawing and pulling a MAT-test.
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| 3. |
- Heintz, Verena, et al.
(författare)
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Achterbahn fahren im Physikunterricht : Roller coasters in Physics Education
- 2009
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Ingår i: Physik in unserer Zeit. - 1521-3943. ; 40:2, s. 90-95
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Das Messen von Beschleunigungen und Höhen während einer Achterbahnfahrt bietet die Möglichkeit, den Physikunterricht anwendungsbezogen zu gestalten. Dieser Ansatz erlaubt einen erlebnisorientierten Zugang speziell im Bereich der oftmals als langweilig empfundenen Mechanik. Das Beispiel der Achterbahn Kanonen in Göteborg demonstriert die vielen Möglichkeiten der Datenauswertung. Außerdem generiert das eigenständige Experimentieren mit einem modernen Messsystem und die Datenauswertung mit Analyse am Computer einen zusätzlichen Lerneffekt.
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| 4. |
- Kisch, Annika M., et al.
(författare)
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A person-centred intervention remotely targeting family caregivers' support needs in the context of allogeneic hematopoietic stem cell transplantation : A feasibility study
- 2022
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Ingår i: Supportive Care in Cancer. - : Springer Science and Business Media LLC. - 0941-4355 .- 1433-7339. ; 30:11, s. 9039-9047
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Allogeneic hematopoietic stem cell transplantation (HSCT) is an intensive curative treatment that increases family caregivers' burden. The aim of this study was to explore the feasibility of remotely assessing and addressing family caregivers' support needs in terms of demand and acceptability using the Carer Support Needs Assessment Tool Intervention (CSNAT-I) in the HSCT context.METHODS: CSNAT-I consists of an evidence-based tool and a five-stage person-centred process. The intervention was performed remotely by two designated nurses from two HSCT centres, one before HSCT and the second 6 weeks after (November 2020 to March 2021). To capture the experiences of using CSNAT-I, interviews were conducted with family caregivers and reflections were gathered from the designated nurses.RESULTS: Of 34 eligible family caregivers, 27 participated, 70% were partners and the rest children, siblings or other relatives. The main support needs were knowing what to expect in the future and dealing with your feelings and worries. The most frequent support actions according to CSNAT-I were psychological support and medical information. Four categories summarised family caregivers and designated nurses' experiences: CSNAT-I was relevant and became an eye opener; nurses' experiences were important for enabling trustful CSNAT-I conversations; CSNAT-I provided family caregivers with support and a sense of security; and CSNAT-I gave family caregivers insight and enabled change.CONCLUSION: Both family caregivers and designated nurses experienced that using CSNAT-I in an HSCT context was feasible and had the potential to provide valuable support for most of the participating family caregivers.
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| 5. |
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| 6. |
- Pendrill, Ann-Marie, et al.
(författare)
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Achterbahn fahren im Physikunterricht
- 2009
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Ingår i: Physik in unserer Zeit. - : Wiley. - 1521-3943 .- 0031-9252. ; 40:2, s. 90-95
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Tidskriftsartikel (refereegranskat)abstract
- Abstract in German Das Messen von Beschleunigungen und Höhen während einer Achterbahnfahrt bietet die Möglichkeit, den Physikunterricht anwendungsbezogen zu gestalten. Dieser Ansatz erlaubt einen erlebnisorientierten Zugang speziell im Bereich der oftmals als langweilig empfundenen Mechanik. Das Beispiel der Achterbahn Kanonen in Göteborg demonstriert die vielen Möglichkeiten der Datenauswertung. Außerdem generiert das eigenständige Experimentieren mit einem modernen Messsystem und die Datenauswertung mit Analyse am Computer einen zusätzlichen Lerneffekt.
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| 7. |
- Söderberg, Simon, et al.
(författare)
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Time and Motion at the Endoscopy Unit-A University Hospital Experience
- 2023
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Ingår i: Health services research and managerial epidemiology. - : Sage Publications. - 2333-3928. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND/AIMS: An effective workflow at the endoscopy unit is important for optimal production. We conducted a time-and-motion study to identify the amount of time that patients spend during the different steps of a regular endoscopy procedure and compared propofol with midazolam sedation.METHODS: Data from 376 patients were prospectively collected. Durations of the different procedure steps were measured. Correlations between recovery times, age, and dose of sedative were calculated. Multiple regression analysis was performed to evaluate how various factors affect recovery time.RESULTS: The use of midazolam resulted in significantly shorter procedure duration for gastroscopy (5.1 vs 8.3 min), shorter endoscopist delay duration for either types of endoscopy (5.9 vs 8.3 min for gastroscopy and 6.7 vs 11.4 min for colonoscopy), shorter endoscopy room duration for gastroscopy (22.2 vs 30.0 min), shorter recovery time for colonoscopy (23.4 vs 27.4 min) and shorter Endoscopy Unit Duration for either type of endoscopy (77.1 vs 101.4 min for gastroscopy and 99.6 vs 123.2 min for colonoscopy). There was a weak correlation between dose of midazolam and recovery time.CONCLUSIONS: In contrast to other studies, propofol administration leads to more time spent at different steps in the workflow at our unit. Implementing propofol sedation will not improve efficacy if other steps in the workflow are not taken into account.
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