| 1. |
- Lundqvist, Anette, et al.
(författare)
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Reported dietary intake in early pregnant compared to non-pregnant women : a cross-sectional study
- 2014
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Ingår i: BMC Pregnancy and Childbirth. - : BioMed Central. - 1471-2393 .- 1471-2393. ; 14:373
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Tidskriftsartikel (refereegranskat)abstract
- Background: A woman's nutritional status before conception and during pregnancy is important for maternal health and the health of the foetus. The aim of the study was to compare diet intake in early pregnant women with non-pregnant women. Methods: Between September 2006 and March 2009, 226 women in early pregnancy were consecutively recruited at five antenatal clinics in Northern Sweden. Referent women (n = 211) were randomly selected from a current health screening project running in the same region (the Vasterbotten Intervention Program; VIP). We collected diet data with a self-reported validated food frequency questionnaire with 66 food items/food aggregates, and information on portion size, alcohol consumption, and supplement intake. Data were analysed using descriptive, comparative statistics and multivariate partial least square modelling. Results: Intake of folate and vitamin D from foods was generally low for both groups. Intake of folate and vitamin D supplements was generally high in the pregnant group and led to significantly higher total estimated intake of vitamin D and folate in the pregnant group. Iron intake from foods tended to be lower in pregnant women although iron supplement intake evened out the difference with respect to iron intake from foods only. Energy intake was slightly lower in pregnant women but not significant, a reflection of that they reported consuming significantly less of potatoes/rice/pasta, meat/fish, and vegetables (grams/day) than the women in the referent group. Conclusions: In the present study, women in early pregnancy reported less intake of vegetables, potatoes, meat, and alcohol than non-pregnant women. As they also had a low intake (below the Nordic Nutritional Recommendations) of folate, vitamin D, and iron from foods, some of these women and their unborn children are possibly at risk for adverse effects on the pregnancy and birth outcome.
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| 2. |
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| 3. |
- Bamia, C., et al.
(författare)
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Fruit and vegetable consumption in relation to hepatocellular carcinoma in a multi-centre, European cohort study
- 2015
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 112:7, s. 1273-1282
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Tidskriftsartikel (refereegranskat)abstract
- Background:Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case-control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associations. Methods: In 486 799 men/women from the European Prospective Investigation into Cancer and nutrition, we identified 201 HCC cases after 11 years median follow-up. We calculated adjusted hazard ratios (HRs) for HCC incidence for sex-specific quintiles and per 100 g d(-1) increments of vegetable/fruit intakes. Results: Higher vegetable intake was associated with a statistically significant, monotonic reduction of HCC risk: HR (100 g d(-1) increment): 0.83; 95% CI: 0.71-0.98. This association was consistent in sensitivity analyses with no apparent heterogeneity across strata of HCC risk factors. Fruit intake was not associated with HCC incidence: HR (100 g d(-1) increment): 1.01; 95% CI: 0.92-1.11. Conclusions: Vegetable, but not fruit, intake is associated with lower HCC risk with no evidence for heterogeneity of this association in strata of important HCC risk factors. Mechanistic studies should clarify pathways underlying this association. Given that HCC prognosis is poor and that vegetables are practically universally accessible, our results may be important, especially for those at high risk for the disease.
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| 4. |
- Baumann, Pia, et al.
(författare)
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Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy.
- 2009
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Ingår i: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755 .- 0732-183X. ; 27:20, s. 3290-6
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The impact of stereotactic body radiotherapy (SBRT) on 3-year progression-free survival of medically inoperable patients with stage I non-small-cell lung cancer (NSCLC) was analyzed in a prospective phase II study. PATIENTS AND METHODS: Fifty-seven patients with T1NOMO (70%) and T2N0M0 (30%) were included between August 2003 and September 2005 at seven different centers in Sweden, Norway, and Denmark and observed up to 36 months. SBRT was delivered with 15 Gy times three at the 67% isodose of the planning target volume. RESULTS: Progression-free survival at 3 years was 52%. Overall- and cancer-specific survival at 1, 2, and 3 years was 86%, 65%, 60%, and 93%, 88%, 88%, respectively. There was no statistically significant difference in survival between patients with T1 or T2 tumors. At a median follow-up of 35 months (range, 4 to 47 months), 27 patients (47%) were deceased, seven as a result of lung cancer and 20 as a result of concurrent disease. Kaplan-Meier estimated local control at 3 years was 92%. Local relapse was observed in four patients (7%). Regional relapse was observed in three patients (5%). Nine patients (16%) developed distant metastases. The estimated risk of all failure (local, regional, or distant metastases) was increased in patients with T2 (41%) compared with those with T1 (18%) tumors (P = .027). CONCLUSION: With a 3-year local tumor control rate higher than 90% with limited toxicity, SBRT emerges as state-of-the-art treatment for medically inoperable stage I NSCLC and may even challenge surgery in operable instances.
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| 5. |
- Baumann, Pia, et al.
(författare)
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Stereotactic body radiotherapy for medically inoperable patients with stage I non-small cell lung cancer - a first report of toxicity related to COPD/CVD in a non-randomized prospective phase II study.
- 2008
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Ingår i: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 88:3, s. 359-67
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND AIMS: In a retrospective study using stereotactic body radiotherapy (SBRT) in medically inoperable patients with stage I NSCLC we previously reported a local control rate of 88% utilizing a median dose of 15Gyx3. This report records the toxicity encountered in a prospective phase II trial, and its relation to coexisting chronic obstructive pulmonary disease (COPD) and cardio vascular disease (CVD). MATERIAL AND METHODS: Sixty patients were entered in the study between August 2003 and September 2005. Fifty-seven patients (T1 65%, T2 35%) with a median age of 75 years (59-87 years) were evaluable. The baseline mean FEV1% was 64% and median Karnofsky index was 80. A total dose of 45Gy was delivered in three fractions at the 67% isodose of the PTV. Clinical, pulmonary and radiological evaluations were made at 6 weeks, 3, 6, 9, 12, 18, and 36 months post-SBRT. Toxicity was graded according to CTC v2.0 and performance status was graded according to the Karnofsky scale. RESULTS: At a median follow-up of 23 months, 2 patients had relapsed locally. No grade 4 or 5 toxicity was reported. Grade 3 toxicity was seen in 12 patients (21%). There was no significant decline of FEV1% during follow-up. Low grade pneumonitis developed to the same extent in the CVD 3/17 (18%) and COPD 7/40 (18%) groups. The incidence of fibrosis was 9/17 (53%) and pleural effusions was 8/17 (47%) in the CVD group compared with 13/40 (33%) and 5/40 (13%) in the COPD group. CONCLUSION: SBRT for stage I NSCLC patients who are medically inoperable because of COPD and CVD results in a favourable local control rate with a low incidence of grade 3 and no grade 4 or 5 toxicity.
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| 6. |
- Bengtsson, Leif, et al.
(författare)
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Effekter på arbetsmiljö och yttre miljö vid byte av metod för blekning av massa
- 1995
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Effekterna på främst arbetsmiljö men även yttre miljö av vid byte av blekkemikalier för blekning av kemisk massa har studerats vid fyra blekerier. Blekeri A har bytt från klordioxid till väteperoxid, blekeri B från klor/klordioxid till väteperoxid, blekeri C och D från klordioxid till ozon/väteperoxid. Blekeri B har en delvis sluten process. Generellt sett har arbetsmiljön och den yttre miljön förbättrats, även om en del oönskade bieffekter också uppkommit. De studerade bytena har inte inneburit att några oacceptabla effekter i arbetsmiljön eliminerats eller tillkommit förutom i ett fall där höga halter väteperoxid uppmättes i arbetsmiljön. Inget av kemikaliebytena har lett till direkta försämringar för den yttre miljön (vattenrecipienten). De tester som har gjorts av det samlade totalavloppsvattnet visar på en minskad giftighet (toxicitet) för vattenlevande organismer. Kunskapsbrist om hälsoeffekter av exponering för ozon talar för försiktig hantering. Förslag på åtgärder för en säkrare ozonhantering och säker och god arbetsmiljö i övrigt vid byte av blekkemikalier redovisas. Den använda metoden för miljöteknisk utvärdering har visat sig användbar vid en övergripande kartläggning av effekter av kemikaliebytet. En svårighet med metoden är att isolera vilka effekter som uppkommer som en direkt följd av kemikaliebytet från sådana effekter som uppkommer av andra orsaker.
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| 7. |
- Bergvall-Kåreborn, Birgitta, et al.
(författare)
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User toolkits for citizen-centric mobild service innovation
- 2012
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Ingår i: eChallenges e-2012 Conference Proceedings. - : IIMC International Information Management Corporation. - 9781905824359
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Konferensbidrag (refereegranskat)abstract
- Around the world, there is an ongoing shift from en economy focusing on product development to an economy with focus on digital service development. An ongoing initiative in Europe to support this shift is the Internet of Services (IoS) which strives for a situation where everything that is needed to use a software is available as a service. The aim of this paper is to present a toolkit that non-programmers can use develop their own innovative mobile services. This environment strives to put forth a situation where technologies are made available as components that easily can be composed into a mobile services by just about anyone. This has tremendous impact on the feasibility of citizen-centric services where citizens create apps based on their current needs in their contemporary situation.
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| 8. |
- Berndtsson, Ronny, et al.
(författare)
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Dagvatten från Växjö tätort. Kvantiteter och kvaliteter samt olika belastningar på olika recipienter.
- 1989
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Föreliggande rapport har genomförts för att kvantifiera föroreningstransporterna med dagvatten från Växjö tätort till de olika recipienterna i kommunen, på månads- och årsbasis. Avbördningen av dagvatten och föroreningstransporter för kväve, fosfor, kemisk syreförbrukning, koppar, zink och bly, har bestämts för 52 olika delområden. Den totala årliga dagvattenvolymen som avrinner från Växjö tätort, till intilliggande recipienter uppgår till 2,94 miljoner m3. De största dagvattenvolymerna förekommer under sommar- och höstmånaderna. Det dagvatten som årligen avrinner från Växjö tätort till de 8 recipienterna innehåller stora kvantiteter föroreningar; 6.300 kg kväve, 330 kg fosfor, 205 ton kemisk syreförbrukning (COD), 107 kg koppar, 298 kg zink och 26 kg bly. Växjösjön är den recipient som mottar den största belastningen av alla recipienterna, Växjösjön är också den till ytan minsta av recipienterna. De i utredningen beräknade belastningarna har inte ställts i relation till andra utsläppskällor. För Växjösjöns del har dock tidigare rapporter behandlat helhetsbilden.
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| 9. |
- Berndtsson, Ronny, et al.
(författare)
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Vatten- och föroreningsbalanser för Växjösjön, dagvattnets kvalitet och kvantitet
- 1988
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- För att bedöma lång- och korttidseffekter av dagvattenutsläpp till Växjösjön har beräkningar gjorts av vattenvolymer och föroreningsmängder för de urbana avrinningsområdena som avbördar till Växjösjön. De parametrar som studerades var: pH, syre, kväve, fosfor, kemisk och biologisk syreförbrukning, tungmetaller, fenoler, olja, PCB och bakterier. För att klarlägga olika källors betydelse för belastningen på Växjösjön upprättades vatten- och föroreningsbalanser. Växjösjöns nuvarande eutrofa tillstånd är inte enbart orsakad av avloppsvattenutsläpp och vattenståndssänkningar, utan även av en ökad dagvattenbelastning med stora mängder närsalter. Den nuvarande belastningen är 0,63 g fosfor/m2 och år, av vilket 8% härrör från nederbörd direkt på sjöytan, 55% från tillflödet från Trummen och 37% från dagvattentillförseln.
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| 10. |
- Björntorp Mark, Elisabeth, 1964, et al.
(författare)
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Expression of genes involved in the regulation of p16 in psoriatic involved skin
- 2006
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Ingår i: Arch Dermatol Res. - : Springer Science and Business Media LLC. - 0340-3696. ; 297:10, s. 459-67
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Tidskriftsartikel (refereegranskat)abstract
- It has been suggested that the up-regulation of the tumour suppressor p16 gene and induction of senescence protect the phenotype of psoriatic involved skin from malignant transformation. On the other hand, Id1, which is inversely correlated with p16 has been shown to be up-regulated in psoriatic involved skin. To test the hypothesis that there may be an altered regulation of p16 in psoriatic involved skin, we have measured genes involved in the Igf-1 receptor signalling through the Ras/MAPK cascade. Igf-1R, IGFBP3, hRas, Ets2, JunB, Egr-1, Id1, MIDA1 and p16 gene expressions were measured using quantitative real-time PCR in total RNA isolated from punch biopsies from psoriatic involved (n = 9) and uninvolved skin (n = 9) and from cutaneous squamous cell cancer (SCC) involved (n = 8) and uninvolved skin (n = 8). The IGFBP3, hRas, JunB, Egr-1, Id1 and MIDA1 genes were up-regulated in psoriatic involved skin compared with uninvolved skin. The p16, JunB and MIDA1 genes were up-regulated in SCC involved skin compared with uninvolved skin. Our results indicate that there may be a balance between the proliferation and induction of senescence in psoriasis. This balance may vary and the psoriatic involved skin represented in this study appears to be in a proliferative state rather than senescence. Furthermore, we suggest that the noted up-regulation of JunB, which has been shown to up-regulate p16, in combination with the previously reported elevation of p16 expression in psoriatic involved skin, may indicate activation of a pathway by which JunB may protect the psoriatic plaque by inducing p16 in an event of malignant stress.
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