| 1. |
- Helo, Petri, et al.
(författare)
-
Distrubution Center Location Analysis for Nordic Countries by Using Network Optimization Tools
- 2018
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Many supply chain and logistics related location decisions are driven by demand. This paper analyses population densities in Sweden, Finland, Norway and partly Denmark and analyses how a minimum impedance approach would set up the distribution center (DC) locations. For each scenario, travel time maps are generated. Firstly, each country is analyzed separately and 1...5 DC cases are analyzed. Then a merged Nordic area is introduced and a similar approach is used to set up 1…6 DCs. Finally, a sensitivity analysis is conducted to study how the large population of Umeå or Vaasa should be increased in order to make the top five in the Nordic level. The results show distribution centers could be formed in the case of population driven demand products. This also gives insight into how the results can vary when changing perspective from national analysis to Nordic level.
|
|
| 2. |
|
|
| 3. |
- Helo, Petri, et al.
(författare)
-
Vägledning för offentliga och privata aktörer vid planering av gränsöverskridande transporter och infrastruktur i Norden
- 2019
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- För att utveckla ett internationellt transportstråk, som Blå vägen TET-E12, krävs prioriteringar, kunskap, finansiering och gränsöverskridande internationell samverkan. På nationell nivå hanteras investeringskalkyler och beslut om åtgärder över nationsgränser mer ad hoc än för projekt som är centralt placerade i nationens nätverk. Det gäller samtliga länder i Norden. Aktörer längs stråk som binder samman gränsregioner har därför en mer komplex situation att hantera än andra regionala aktörer. Behovet att bygga en egen regionalt förankrad kompetens inom transportpolitik, transportekonomi, logistik, planering, fastighetsutveckling och data är här betydande. Vägledningen sammanfattar bl.a. erfarenheter från intervjuer med regionala aktörer som arbetat med olika gränsöverskridande projekt i Norden samt företrädare för nationella myndigheter. BA3NET har här arbetat nära INTERREG Botnia-Atlantica projektet ”E12 Atlantica Transport”.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Sandberg Hanssen, Thor-Erik, et al.
(författare)
-
Dissimilarities between the national cost/benefit models of road projects : Comparing appraisals in Nordic countries
- 2020
-
Ingår i: Transportation research Interdisciplinary Perspectives. - : Elsevier. - 2590-1982. ; 8
-
Tidskriftsartikel (refereegranskat)abstract
- The Nordic Council has a vision to create the most integrated region globally by 2030. Nevertheless, Nordic cross-border infrastructure projects are generally developed by each nation individually. Joint Nordic infrastructure planning is thus fragmented. An example of this, as reported herein, is how road projects are assessed by the infrastructure planning authorities in Norway, Sweden, and Finland, the latter to which is included in the comparison for the first time. In each country, cost/benefit analyses (CBAs) are used. In each nation, the monetary values of changes in travel time, accidents, and environmental externalities are estimated. We then apply those values to the three national CBA models to assess an illustrative hypothetical road project. Theoretically, the models should provide similar outcomes when using a common set of parameters. Instead, we show that the choice of national model is crucial to the outcome. The Swedish model, for example, generates a higher cost of travel time than the other models irrespective of the nation from which we choose the parameters. Consequently, CBA-based assessments in the Nordic area depend strongly on the model applied and peculiarities in its coding. Finally, we discuss the policy implications of our findings for appraising national and Nordic projects.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Alestig, Erik, 1973, et al.
(författare)
-
Core mutations, IL28B polymorphisms and response to peginterferon/ribavirin treatment in Swedish patients with hepatitis C virus genotype 1 infection
- 2011
-
Ingår i: BMC Infectious Diseases. - : Springer Science and Business Media LLC. - 1471-2334. ; 11
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Patients infected with hepatitis C virus (HCV) genotype 1 respond poorly to standard treatment with 50% or less achieving sustained virologic response. Predicting outcome is essential and could help avoid unnecessary treatment and reduce health cost. Recently, an association of amino acid substitutions in the core region and treatment outcome was observed in Japanese patients. In the present study, the impact of these mutations on response kinetics and treatment outcome was explored in Caucasian patients. Methods: The core region of HCV pre-treatment samples obtained from 50 patients treated with peginterferon/ribavirin in a previous Swedish clinical trial with genotype 1 infection were sequenced. The alleles at rs12979860, a single nucleotide polymorphism (SNP), were assessed in order to identify any co-association with this strong response predictor. Results: No association between treatment response and substitutions of core residue 91 was found. In contrast, substitutions of core residue 70 were observed in 6/21 (29%) non-responders, but only in one of 29 responders (p = 0.03), and were more common in subgenotype 1b (R70Q in 6 of 13 strains) than in 1a (R70P in 1 of 37 strains, p = 0.004). The rs12979860 SNP upstream of the IL28B gene was overall the strongest response predictor (p = 0.0001). Core 70 substitutions were associated with poorer response kinetics in patients carrying the CT genotype at rs12979860. Conclusions: The results indicate that substitutions of core residue 70 are related to treatment response in Caucasian patients with HCV-1b infection, but are of less importance than IL28B polymorphism.
|
|
| 10. |
|
|
